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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 66 0 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(VSIR)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 118.92199707 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 229.36199951 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(VS)-1(IR)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.3789978 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 160.8789978 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 166.1289978 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(VSIR)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 102.86199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 105.23600006 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 134.00799561 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 136.38200378 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 186.70300293 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 189.07699585 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 226.8730011 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000C000E>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(V-)-1(se)1(t)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 85.01999664 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 91.30500031 12.82499981 Tm [(immu)-1(nore)1(gu)-1(latory)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 171.31100464 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 177.59599304 12.82499981 Tm [(re)1(ceptor;)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 217.18600464 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 223.47099304 12.82499981 Tm [(B7H5;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 249.17799377 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 255.46299744 12.82499981 Tm [(GI24)1(;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 278.18600464 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 284.4710083 12.82499981 Tm [(B7-H5;)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 313.39199829 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 319.67700195 12.82499981 Tm [(PD-1H;)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 349.44900513 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 355.73400879 12.82499981 Tm [(SIS)-1(P1)1(;)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 381.58401489 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 387.86898804 12.82499981 Tm [(VIS)-1(TA;)] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 415.29800415 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 0 30.49699783 Tm [(PP)1(2135;)] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 34.94499969 30.49699783 Tm [( )] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 37.31900024 30.49699783 Tm [(C10orf54;)] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 79.41600037 30.49699783 Tm [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 81.79000092 30.49699783 Tm [(DD1al)-1(ph)-1(a)] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 123.53399658 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000E>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000E>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000E>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(VS)-1(IR)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 82.1289978 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <</Lang (zh-CN) /MCID 74 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001F002000210022000E>] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <</Lang (zh-CN) /MCID 78 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002300240025000E>] TJ ET EMC /P <</MCID 79 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <</Lang (zh-CN) /MCID 83 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130026000E>] TJ ET EMC /P <</MCID 84 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <</MCID 89 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 90 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 91 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 431.32901001 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 92 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 42.92200089 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 93 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 78.75 l 138.67500305 78.75 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 94 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunoregulato)1(ry)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 80.81500244 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 85.31500244 11.72200012 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 121.73699951 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 126.23699951 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 151.33399963 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 155.83399963 11.72200012 Tm [(inhibits)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 187.37399292 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 191.87399292 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 205.875 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 210.375 11.72200012 Tm [(T-ce)-1(ll)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 233.83700562 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 238.33700562 11.72200012 Tm [(respons)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(\(PubMed:)1(2)-1(46)-1(91)-1(993)-1(\).)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 98.62999725 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 103.12999725 27.3220005 Tm [(May)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 121.66200256 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 126.16200256 27.3220005 Tm [(pro)1(mote)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 163.68299866 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 168.18299866 27.3220005 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 229.50900269 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 234.00900269 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 242.85099792 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 247.35099792 27.3220005 Tm [(embry)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(onic)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 18.1760006 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 22.6760006 42.92200089 Tm [(st)1(e)-1(m)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 43.73500061 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 48.23500061 42.92200089 Tm [(ce)-1(lls,)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 68.97699738 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 73.47699738 42.92200089 Tm [(by)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 83.98899841 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 88.48899841 42.92200089 Tm [(inhibiting)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 129.55999756 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 134.05999756 42.92200089 Tm [(BMP4)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 159.28500366 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 163.78500366 42.92200089 Tm [(signaling)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 202.71600342 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 207.21600342 42.92200089 Tm [(\(By)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 220.63299561 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 225.13299561 42.92200089 Tm [(similarit)1(y)-1(\).)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 269.01199341 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(May)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 18.53199959 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 23.03199959 58.52199936 Tm [(st)1(i)-1(mulat)1(e)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 62.75400162 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 67.2539978 58.52199936 Tm [(MMP14)-1(-)1(me)-1(d)1(i)-1(a)1(ted)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 145.67900085 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 150.17900085 58.52199936 Tm [(MMP2)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 178.55000305 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 183.05000305 58.52199936 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 225 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 229.5 58.52199936 Tm [(\(PubMed:)1(2)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(06)-1(66)-1(77)-1(7\).)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 42.11700058 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 78.75 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 151 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 152 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 153 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(FC)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 32.27399826 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.09999847 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 157 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 162 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 163 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(VSIR)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 19.80200005 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 111.44999695 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 165 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <</MCID 166 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 167 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(VSIR)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 136.147995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.80000305 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 177 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 180 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 181 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(V-set)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 22.60499954 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 27.10499954 11.72200012 Tm [(immun)-1(o)1(re)-1(g)1(ulator)1(y)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 107.66999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 112.16999817 11.72200012 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 148.59199524 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.1499939 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 187 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 188 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 138.67500305 31.95000076 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 189 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(B7)-1(H5)-1(;)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 25.32999992 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 29.82999992 11.72200012 Tm [(GI24;)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 51.89099884 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 56.39099884 11.72200012 Tm [(B7)-1(-)1(H)-1(5;)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 85.61499786 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 90.11499786 11.72200012 Tm [(PD-)1(1)-1(H;)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 120.77600098 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 125.27600098 11.72200012 Tm [(SISP1;)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 151.26100159 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 155.76100159 11.72200012 Tm [(VIST)-1(A)1(;)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 183.34500122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 187.84500122 11.72200012 Tm [(PP213)-1(5;)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 222.13600159 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 226.63600159 11.72200012 Tm [(C10)-1(or)1(f54)-1(;)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 268.2130127 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(DD)1(1)-1(alp)1(ha)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 42.6230011 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 176.09999084 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 0.75 m 138.30000305 78.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 79.5 m 138.30000305 95.09999847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 95.84999847 m 138.30000305 111.44999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 112.19999695 m 138.30000305 127.79999542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 128.54998779 m 138.30000305 144.1499939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 144.8999939 m 138.30000305 176.09999084 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 176.09999084 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.125 m 422.42498779 79.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 95.47499847 m 422.42498779 95.47499847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.82499695 m 422.42498779 111.82499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.17498779 m 422.42498779 128.17498779 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 144.5249939 m 422.42498779 144.5249939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 176.47499084 m 423.17498779 176.47499084 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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