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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 66 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(VRK2)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 125.83999634 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 236.27999878 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(VRK2)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 111.68599701 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 164.18600464 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.43600464 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(VRK)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.16899872 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.54299927 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.31500244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.68899536 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.00999451 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.38400269 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.17999268 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(vacc)1(i)-1(ni)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.01699829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.39099884 12.82499981 Tm [(re)1(l)-1(ate)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.9730072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.34700012 12.82499981 Tm [(kinas)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.40699768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.78100586 12.82499981 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.10299683 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(VRK2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.43599701 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002300240025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 138.67500305 125.55000305 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(vacc)-1(inia-)1(re)-1(la)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.33500671 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.83500671 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.92300415 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(\(VRK\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.68700027 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.18700027 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.26900101 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.76900101 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.61100006 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.11100006 27.3220005 Tm [(serine)-1(/th)1(re)-1(o)1(n)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.46499634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.96499634 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.27200317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.77200317 27.3220005 Tm [(ki)-1(na)1(se)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.19200134 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.69200134 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.49899292 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.99899292 27.3220005 Tm [(en)-1(cod)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.56399918 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.06399918 42.92200089 Tm [(acts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.07099915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.57099915 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.71199799 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.21199799 42.92200089 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.73300171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.23300171 42.92200089 Tm [(effec)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.71099854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.21099854 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.05299377 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.55299377 42.92200089 Tm [(signaling)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.48399353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.98399353 42.92200089 Tm [(pa)1(thw)1(ays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.61099243 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.11099243 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.33299255 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.83300781 42.92200089 Tm [(reg)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ulate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.375 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.875 58.52199936 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.8690033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.3690033 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.64600372 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.14600372 58.52199936 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.63600159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.13600159 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.54600525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.04600525 58.52199936 Tm [(gr)1(owt)1(h.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.12800598 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.62800598 58.52199936 Tm [(Variant)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.55999756 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.05999756 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.00100708 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.50100708 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.95700073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.45700073 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.97299194 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.34700012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.84700012 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.35400009 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.85400009 74.12200165 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.98100281 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.48100281 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.8769989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.3769989 74.12200165 Tm [(schizop)1(hreni)-1(a)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 74.12200165 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.2769928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.7769928 74.12200165 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.69198608 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.16900063 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.66899872 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.61000061 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.11000061 89.72200012 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.48200226 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.98200226 89.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.90399933 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.40400696 89.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.97399902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.47399902 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.69599915 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.19599915 89.72200012 Tm [(dif)1(fe)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.1309967 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.6309967 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.57200623 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.07200623 89.72200012 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.90499878 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.40499878 89.72200012 Tm [(subc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ell)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.24900055 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.74900055 105.3219986 Tm [(localizat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.55899811 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.05899811 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.33599854 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.83599854 105.3219986 Tm [(biolo)1(gic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.852005 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.352005 105.3219986 Tm [(activit)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.99000549 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.49000549 105.3219986 Tm [([pr)1(ovided)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.14100647 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.64100647 105.3219986 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.15299988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.65299988 105.3219986 Tm [(RefSe)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(q,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.92299986 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.42300034 120.92199707 Tm [(Jan)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.50699997 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.00699997 120.92199707 Tm [(20)-1(14)-1(])] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.12400055 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(VRK2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.95299911 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(VRK2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.29899597 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 174.6000061 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(vacc)-1(inia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.0359993 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.5359993 11.72200012 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.66500092 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.16500092 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.25299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.75299835 11.72200012 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.03099823 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 190.94999695 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Q86)-1(Y)1(0)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.8769989 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 207.30003357 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 0.75 m 138.30000305 125.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 126.30000305 m 138.30000305 141.90000916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 142.65000916 m 138.30000305 158.25001526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 159.00001526 m 138.30000305 174.60002136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 175.35002136 m 138.30000305 190.95002747 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 191.70002747 m 138.30000305 207.30003357 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 207.30003357 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 174.97502136 m 422.42498779 174.97502136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 191.32502747 m 422.42498779 191.32502747 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 207.67503357 m 423.17498779 207.67503357 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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