%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 141 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 66 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 137.76400757 23.67700005 Tm 0 Tr [(VP)-1(S)1(28)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 200.68099976 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 311.1210022 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 344.1210022 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.68499756 12.82499981 Tm [(VPS28)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 124.16000366 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 176.66000366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.91000366 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000E000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.31000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(VPS28)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.58300018 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.95700073 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.72900391 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.10299683 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.42399597 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.79800415 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.59399414 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(MGC6032)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.80899811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(VPS28)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.84999847 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 113.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.36000061 12.82499981 Tm [(Do)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.2990036 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.67299652 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.29299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.66699982 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.91499329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.28900146 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.90899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.28300476 12.82499981 Tm [(Mon)-1(k)1(ey)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.06399536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.43800354 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.05799866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.43200684 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.79400635 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<002000210022000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800220027>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q /GS2 gs 1 g 0.375 0.75 m 148.42500305 0.75 l 148.42500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 149.42500305 -0.25 l 149.42500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.17500305 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 149.17500305 109.94999695 l h f* Q q 1 0 0 1 148.80000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.1190033 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.6190033 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.61999512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.11999512 11.72200012 Tm [(ESCRT-I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.85699463 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.35699463 11.72200012 Tm [(comp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(lex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.06299973 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.56299973 27.3220005 Tm [(\(en)-1(d)1(osoma)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.38999939 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.88999939 27.3220005 Tm [(complexe)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.64099884 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.14099884 27.3220005 Tm [(required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.68200684 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.18200684 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.46000671 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.96000671 27.3220005 Tm [(tr)1(anspor)1(t\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.86799622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.36799622 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.46499634 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.96499634 27.3220005 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(unc)-1(t)1(i)-1(o)1(n)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.78699875 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.28699875 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.22800064 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.72800064 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.72899628 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.22899628 42.92200089 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.96399689 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.46399689 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.74099731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.24099731 42.92200089 Tm [(sor)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.61599731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.11599731 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.95799255 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.45799255 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.93099976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.43099976 42.92200089 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.44700623 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.94700623 42.92200089 Tm [(sub)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.76199913 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.26200104 58.52199936 Tm [(vesic)-1(les.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.00099945 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.50099945 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.76300049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.26300049 58.52199936 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.74200439 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.24200439 58.52199936 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.27600098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.77600098 58.52199936 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.03300476 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.53300476 58.52199936 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.38699341 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.88699341 58.52199936 Tm [(hijack)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.47799683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.97799683 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.05299377 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.55299377 58.52199936 Tm [(fa)1(c)-1(il)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ita)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.18199921 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.68199921 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.68299866 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.18299866 74.12200165 Tm [(budd)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.68800354 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.18800354 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.02999878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.52999878 74.12200165 Tm [(en)-1(v)1(e)-1(lop)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.74099731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.24099731 74.12200165 Tm [(viruses)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.78100586 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.28100586 74.12200165 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.99200439 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.49200439 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.49299622 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.99299622 74.12200165 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.40299988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.90299988 74.12200165 Tm [(mem)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(bra)1(ne)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.97800064 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.47800064 89.72200012 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.2009964 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.7009964 89.72200012 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.61599731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.11599731 89.72200012 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.28500366 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.78500366 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.72599792 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.22599792 89.72200012 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.5980072 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.0980072 89.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.02000427 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.52000427 89.72200012 Tm [(var)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ants)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.04000092 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.54000092 105.3219986 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.88199997 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.38200378 105.3219986 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.3219986 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.8219986 105.3219986 Tm [(isof)1(orms.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.14900208 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q /GS2 gs 1 g 0.375 0.75 m 148.42500305 0.75 l 148.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 149.42500305 -0.25 l 149.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 149.17500305 16.35000038 l h f* Q q 1 0 0 1 148.80000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.26499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.76499939 11.72200012 Tm [(IF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.19200134 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 148.42500305 0.75 l 148.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 149.42500305 -0.25 l 149.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 149.17500305 16.35000038 l h f* Q q 1 0 0 1 148.80000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(VPS2)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.34300041 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q /GS2 gs 1 g 0.375 0.75 m 148.42500305 0.75 l 148.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 149.42500305 -0.25 l 149.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 149.17500305 16.35000038 l h f* Q q 1 0 0 1 148.80000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(VPS2)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.68899536 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159 cm q /GS2 gs 1 g 0.375 0.75 m 148.42500305 0.75 l 148.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 149.42500305 -0.25 l 149.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 149.17500305 16.35000038 l h f* Q q 1 0 0 1 148.80000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(VPS2)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.34300041 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.84300041 11.72200012 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.14299774 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.64299774 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.98500061 11.72200012 Tm [(ESCRT-I)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.72200012 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 175.3500061 cm q /GS2 gs 1 g 0.375 0.75 m 148.42500305 0.75 l 148.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 149.42500305 -0.25 l 149.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 149.17500305 16.35000038 l h f* Q q 1 0 0 1 148.80000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9UK41)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.59999847 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 191.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 148.42500305 0.75 l 148.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 149.42500305 -0.25 l 149.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.47100067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.97100067 11.72200012 Tm [(positive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.80799866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.30799866 11.72200012 Tm [(control:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 96.39399719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 149.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 149.17500305 16.35000038 l h f* Q q 1 0 0 1 148.80000305 0 cm -0.625 -0.25 m 274.625 -0.25 l 274.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.04100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.54100037 11.72200012 Tm [(pa)1(n)-1(creas)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.0059967 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.5059967 11.72200012 Tm [(tiss)1(u)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.23799896 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.05001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.80000305 0.75 m 148.80000305 109.94999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.80000305 110.69999695 m 148.80000305 126.29999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.80000305 127.04999542 m 148.80000305 142.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.80000305 143.3999939 m 148.80000305 159 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.80000305 159.75 m 148.80000305 175.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.80000305 176.1000061 m 148.80000305 191.70001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 148.80000305 192.45001221 m 148.80000305 208.05001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 208.05001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 110.32499695 m 422.42498779 110.32499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 126.67499542 m 422.42498779 126.67499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.0249939 m 422.42498779 143.0249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 159.375 m 422.42498779 159.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 175.7250061 m 422.42498779 175.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 192.07501221 m 422.42498779 192.07501221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 208.42501831 m 423.17498779 208.42501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>