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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 88 0 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(US)1(P)-1(40)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 136.03500366 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 246.4750061 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(USP40)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 127.3789978 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.8789978 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 185.1289978 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(U)1(S)-1(P)1(40)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 111.36299896 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 113.73699951 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 142.50900269 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 144.88299561 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 195.20399475 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 197.57800293 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 235.37399292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 101.32900238 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 103.70300293 12.82499981 Tm [(sp)-1(e)1(cif)-1(ic)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 135.45399475 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 137.82800293 12.82499981 Tm [(pepti)-1(dase)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 179.88999939 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 182.26400757 12.82499981 Tm [(40)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 192.90800476 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(USP40)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 90.6289978 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001F002000210022000E>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 63 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0023>] TJ ET EMC /P <</MCID 64 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 72 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130026000E>] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 78 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 81 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 138.67500305 94.34999847 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 83 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Mod)1(i)-1(f)1(ic)-1(at)1(ion)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 54.68600082 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 59.18600082 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 68.02799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 72.52799988 11.72200012 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 103.29000092 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 107.79000092 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 143.26300049 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 147.76300049 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 158.2749939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 162.7749939 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 201.45599365 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 205.95599365 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 212.51699829 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 217.01699829 11.72200012 Tm [(an)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 227.53799438 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 232.03799438 11.72200012 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 269.2460022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(regulat)1(ory)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 44.49000168 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 48.99000168 27.3220005 Tm [(mec)-1(ha)1(n)-1(ism)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 98.09899902 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 102.59899902 27.3220005 Tm [(controlled)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 146.54400635 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 151.04400635 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 161.55599976 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 166.05599976 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 180.05700684 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 184.55700684 27.3220005 Tm [(coord)1(i)-1(na)1(ted)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 236.83900452 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 241.33900452 27.3220005 Tm [(action)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 267.8420105 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 8.84200001 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 13.34200001 42.92200089 Tm [(multiple)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 48.7140007 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 53.2140007 42.92200089 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 147.30099487 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 151.80099487 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 168.07800293 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 172.57800293 42.92200089 Tm [(deubiquitinat)1(in)-1(g)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 244.14700317 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 248.64700317 42.92200089 Tm [(en)-1(z)1(y)-1(m)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(es.)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 11.43900013 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 15.93900013 58.52199936 Tm [(USP40)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 43.91500092 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 48.41500092 58.52199936 Tm [(belongs)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 82.85500336 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 87.35500336 58.52199936 Tm [(to)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 96.43000031 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 100.93000031 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 105.90499878 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 110.40499878 58.52199936 Tm [(larg)1(e)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 132.07400513 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 136.57400513 58.52199936 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 162.65600586 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 167.15600586 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 175.9980011 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 180.4980011 58.52199936 Tm [(cy)-1(st)1(e)-1(ine)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 215.44799805 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 219.94799805 58.52199936 Tm [(pro)1(teases)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 261.72698975 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 266.22698975 58.52199936 Tm [(th)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(at)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 8.32800007 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 12.82800007 74.12200165 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 48.56900024 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 53.06900024 74.12200165 Tm [(as)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 62.20999908 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 66.70999908 74.12200165 Tm [(deubiquitinat)1(in)-1(g)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 138.27900696 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 142.77900696 74.12200165 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 180.32600403 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 184.82600403 74.12200165 Tm [(\(Que)-1(s)1(ada)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 225.69099426 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 230.19099426 74.12200165 Tm [(et)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 238.6499939 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 243.1499939 74.12200165 Tm [(al.,)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 254.85299683 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 259.35299683 74.12200165 Tm [(20)-1(0)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(4)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 5.27799988 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 9.77799988 89.72200012 Tm [([PubMed)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 49.24100113 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 53.74100113 89.72200012 Tm [(14)-1(71)-1(52)-1(45]\).[supplied)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 144.00900269 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 148.50900269 89.72200012 Tm [(by)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 159.02099609 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 163.52099609 89.72200012 Tm [(OMIM,)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 193.2539978 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 197.7539978 89.72200012 Tm [(Mar)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 214.95899963 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 219.45899963 89.72200012 Tm [(20)-1(08)-1(])] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 243.57600403 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 94.34999847 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 178 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 179 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 180 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 110.69999695 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 184 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 189 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 190 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(USP40)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 27.97599983 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.05000305 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 192 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <</MCID 193 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 194 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(USP40)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 144.32200623 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 143.3999939 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 204 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 207 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 208 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ubiquitin)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 75.13800049 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 79.63800049 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 121.99199677 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 126.49199677 11.72200012 Tm [(40)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 137.04800415 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159.75 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 216 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <</MCID 217 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 218 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Q9NV)-1(E)1(5)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 36.24200058 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 176.1000061 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 220 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 16.47100067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 20.97100067 11.72200012 Tm [(positive)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 56.80799866 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 61.30799866 11.72200012 Tm [(control:)] TJ ET EMC /P <</MCID 225 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 96.39399719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 226 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Hu)-1(ma)1(n)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 31.45999908 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 35.95999908 11.72200012 Tm [(pa)1(n)-1(creas)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 74.42500305 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 78.92500305 11.72200012 Tm [(tiss)1(u)-1(e)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 103.65699768 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 192.44999695 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 232 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 16.47100067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 20.97100067 11.72200012 Tm [(Recommend)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 77.78299713 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 82.28299713 11.72200012 Tm [(di)1(lution:)] TJ ET EMC /P <</MCID 237 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 120.1289978 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 238 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(20)-1(0-50)-1(0)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 35.56100082 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.80001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 0.75 m 138.30000305 94.34999847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 95.09999847 m 138.30000305 110.69999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 111.44999695 m 138.30000305 127.04999542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 127.79999542 m 138.30000305 143.3999939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 144.1499939 m 138.30000305 159.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 160.5 m 138.30000305 176.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 176.8500061 m 138.30000305 192.45001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 193.20001221 m 138.30000305 208.80001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 208.80001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 94.72499847 m 422.42498779 94.72499847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.07499695 m 422.42498779 111.07499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 127.42499542 m 422.42498779 127.42499542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.7749939 m 422.42498779 143.7749939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.125 m 422.42498779 160.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 176.4750061 m 422.42498779 176.4750061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 192.82501221 m 422.42498779 192.82501221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17501831 m 423.17498779 209.17501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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