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290.4750061 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 8 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 9 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 10 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.68499756 12.82499981 Tm [(USP36)] TJ ET EMC /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 124.93900299 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 177.43899536 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 182.68899536 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 14 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000B000C000D>] TJ ET EMC /P <</MCID 15 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(U)1(S)-1(P)1(36)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 111.36299896 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 113.73699951 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 142.50900269 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 144.88299561 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 195.20399475 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 197.57800293 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 235.37399292 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 26 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <</MCID 27 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 28 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C>] TJ ET EMC /P <</MCID 29 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DUB1)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 87.23000336 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(USP36)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 90.6289978 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0012>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001A>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(,)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 101.36000061 12.82499981 Tm [(Do)-1(g)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 118.2990036 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002000210022000F>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 71 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 74 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0024>] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 76 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <</MCID 77 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 78 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <</MCID 79 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 84 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800220027>] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 91 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 92 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 93 >> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 94 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 50.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 95 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 146.17500305 94.34999847 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 96 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Mod)1(i)-1(f)1(ic)-1(at)1(ion)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 54.68600082 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 59.18600082 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 68.02799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 72.52799988 11.72200012 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 103.29000092 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 107.79000092 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 143.26300049 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 147.76300049 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 158.2749939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 162.7749939 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 201.45599365 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 205.95599365 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 212.51699829 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 217.01699829 11.72200012 Tm [(an)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 227.53799438 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 232.03799438 11.72200012 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 269.2460022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(regulat)1(ory)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 44.49000168 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 48.99000168 27.3220005 Tm [(mec)-1(ha)1(n)-1(ism)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 98.09899902 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 102.59899902 27.3220005 Tm [(controlled)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 146.54400635 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 151.04400635 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 161.55599976 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 166.05599976 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 180.05700684 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 184.55700684 27.3220005 Tm [(coord)1(i)-1(na)1(ted)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 236.83900452 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 241.33900452 27.3220005 Tm [(action)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 267.8420105 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 8.84200001 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 13.34200001 42.92200089 Tm [(multiple)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 48.7140007 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 53.2140007 42.92200089 Tm [(ubiquitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 147.30099487 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 151.80099487 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 168.07800293 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 172.57800293 42.92200089 Tm [(deubiquitinat)1(in)-1(g)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 244.14700317 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 248.64700317 42.92200089 Tm [(en)-1(z)1(y)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(mes.)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 19.87199974 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 24.37199974 58.52199936 Tm [(USP36)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 52.34799957 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 56.84799957 58.52199936 Tm [(belongs)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 91.28800201 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 95.78800201 58.52199936 Tm [(to)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 104.86299896 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 109.36299896 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 114.33799744 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 118.83799744 58.52199936 Tm [(larg)1(e)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 140.50700378 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 145.00700378 58.52199936 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 171.08900452 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 175.58900452 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 184.43099976 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 188.93099976 58.52199936 Tm [(cy)-1(st)1(e)-1(ine)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 223.8809967 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 228.3809967 58.52199936 Tm [(pro)1(tease)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(s)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 4.16599989 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 8.66600037 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 25.88800049 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 30.38800049 74.12200165 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 66.1289978 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 70.6289978 74.12200165 Tm [(as)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 79.76999664 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 84.26999664 74.12200165 Tm [(deubiquitinat)1(ing)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 155.83900452 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 160.33900452 74.12200165 Tm [(en)-1(z)1(y)-1(mes)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 197.88600159 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 202.38600159 74.12200165 Tm [(\(Que)-1(s)1(ada)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 243.25100708 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 247.75100708 74.12200165 Tm [(et)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 256.20999146 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 260.70999146 74.12200165 Tm [(al)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(.,)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 4.33300018 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 8.83300018 89.72200012 Tm [(20)-1(04)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 29.94400024 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 34.44400024 89.72200012 Tm [([PubMed)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 73.90699768 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 78.40699768 89.72200012 Tm [(14)-1(71)-1(52)-1(45]\).[supplied)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 168.67500305 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 173.17500305 89.72200012 Tm [(by)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 183.68699646 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 188.18699646 89.72200012 Tm [(OMIM].)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 220.92599487 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 94.34999847 cm q 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 187 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 188 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 189 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC,)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 39.26499939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 43.76499939 11.72200012 Tm [(IF)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 51.19200134 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 110.69999695 cm q 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 195 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 200 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 201 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(USP36)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 27.97599983 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.05000305 cm q 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 203 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <</MCID 204 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 205 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(USP36)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 144.32200623 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 143.3999939 cm q 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 215 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 218 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 219 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ubiquitin)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 75.13800049 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 79.63800049 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 121.99199677 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 126.49199677 11.72200012 Tm [(36)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 137.04800415 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 141.54800415 11.72200012 Tm [(\(USP36\))] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 175.53500366 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159.75 cm q 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 229 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 230 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 231 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(DU)1(B)-1(1)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 24.5 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 176.1000061 cm q 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 233 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <</MCID 234 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 235 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Q9P2)-1(75)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 33.95199966 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 192.44999695 cm q 1 g 0.375 0.75 m 145.42500305 0.75 l 145.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 146.42500305 -0.25 l 146.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 237 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 16.47100067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 20.97100067 11.72200012 Tm [(positive)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 56.80799866 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 61.30799866 11.72200012 Tm [(control:)] TJ ET EMC /P <</MCID 242 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 96.39399719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 146.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.17500305 16.35000038 l h f* Q q 1 0 0 1 145.80000305 0 cm -0.625 -0.25 m 277.625 -0.25 l 277.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 243 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(carc)-1(inoma)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 44.50799942 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 49.00799942 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 57.84999847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 62.34999847 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 92.39099884 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 96.89099884 11.72200012 Tm [(lun)-1(g)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 116.13500214 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 120.63500214 11.72200012 Tm [(tiss)1(u)-1(e)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 145.36700439 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.80001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 0.75 m 145.80000305 94.34999847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 95.09999847 m 145.80000305 110.69999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 111.44999695 m 145.80000305 127.04999542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 127.79999542 m 145.80000305 143.3999939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 144.1499939 m 145.80000305 159.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 160.5 m 145.80000305 176.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 176.8500061 m 145.80000305 192.45001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 145.80000305 193.20001221 m 145.80000305 208.80001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 208.80001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 94.72499847 m 422.42498779 94.72499847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.07499695 m 422.42498779 111.07499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 127.42499542 m 422.42498779 127.42499542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.7749939 m 422.42498779 143.7749939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.125 m 422.42498779 160.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 176.4750061 m 422.42498779 176.4750061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 192.82501221 m 422.42498779 192.82501221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17501831 m 423.17498779 209.17501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
endobj
6 0 obj
<</Length1 127 0 R/Length 27180>>stream
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