%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 136 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 66 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(US)1(P)-1(9X)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 137.00100708 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 247.44099426 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.44100952 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.68499756 12.82499981 Tm [(USP9X)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 125.06700134 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 177.56700134 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.81700134 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(U)1(S)-1(P)1(9X)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.49099731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.86499786 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.63699341 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.01100159 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.33200073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.70599365 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.5019989 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(DF)-1(FRX;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.06999969 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.44400024 12.82499981 Tm [(FAF)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.97799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.35199738 12.82499981 Tm [(FAM;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.03900146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.41299438 12.82499981 Tm [(MRX99)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.18499756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(USP9X)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.75700378 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.36000061 12.82499981 Tm [(Do)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.2990036 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.67299652 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.29299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.66699982 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.91499329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.28900146 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.90899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.28300476 12.82499981 Tm [(Mon)-1(k)1(ey)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.06399536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.43800354 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.05799866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.43200684 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.79400635 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002000210022000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800220027>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 58.52199936 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 140.92500305 109.94999695 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3390007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.8390007 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.81399918 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.31400299 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.57800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.07800293 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.91999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.41999817 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.42100525 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.92100525 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.2749939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.7749939 11.72200012 Tm [(C19)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.35099792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.85099792 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.93299866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.43299866 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.71000671 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.20999146 11.72200012 Tm [(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(codes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.26399994 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.76399994 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.73899841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.23899841 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.54599762 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.04599762 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.26799774 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.76799774 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.32900238 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.82900238 27.3220005 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.02400208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.52400208 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.59899902 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.09899902 27.3220005 Tm [(ubiquitin-)1(spec)-1(ific)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.63000488 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.13000488 27.3220005 Tm [(pro)1(tease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.83300018 42.92200089 Tm [(Though)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.09999847 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.59999847 42.92200089 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.05599976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.55599976 42.92200089 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.0719986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.5719986 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.13300323 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.63300323 42.92200089 Tm [(located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.45399475 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.95399475 42.92200089 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.22200012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.72200012 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.7230072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.2230072 42.92200089 Tm [(X)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.02799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.52799988 42.92200089 Tm [(chromos)1(ome)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.48899841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.98899841 42.92200089 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.73699951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.23699951 42.92200089 Tm [(esc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ap)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.99500084 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.49500084 58.52199936 Tm [(X-inactiva)1(tion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.25099945 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.75099945 58.52199936 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.6000061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.1000061 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.04100037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.54100037 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.99699402 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.49699402 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.01300049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.51300049 58.52199936 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.86000061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.36000061 58.52199936 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.86700439 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.36700439 58.52199936 Tm [(asso)1(c)-1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(at)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.19099998 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.69099998 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.0870018 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.5870018 74.12200165 Tm [(Turn)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.81700134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.31700134 74.12200165 Tm [(syndrome.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.41400146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.91400146 74.12200165 Tm [(Alt)1(e)-1(rna)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.51800537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.01800537 74.12200165 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.97200012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.47200012 74.12200165 Tm [(splice)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.79598999 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.29598999 74.12200165 Tm [(v)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(aria)1(n)-1(t)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.01199913 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.51200104 89.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.85399628 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.35399628 89.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.29399872 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.79399872 89.72200012 Tm [(isof)1(orms,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.1210022 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.6210022 89.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.96800232 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.46800232 89.72200012 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.9750061 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.4750061 89.72200012 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.66699982 105.3219986 Tm [([pr)1(ovided)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.31800079 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.81800079 105.3219986 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.33000183 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.83000183 105.3219986 Tm [(RefSeq].)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.16200256 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(USP9X)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.50300026 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(USP9X)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.84899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 19.52199936 Tm 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 140.92500305 31.95000076 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.13800049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.63800049 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.99199677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.49199677 11.72200012 Tm [(9,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93600464 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43600464 11.72200012 Tm [(X-link)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.23399353 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.73399353 11.72200012 Tm [(\(USP9X\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.41499329 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.91499329 11.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.83700562 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.33700562 11.72200012 Tm [(v)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(aria)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.68000031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.18000031 27.3220005 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.45800018 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 190.94999695 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(DFFRX;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.26499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.76499939 11.72200012 Tm [(FAF;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.82699966 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.32699966 11.72200012 Tm [(FAM;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.40100098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.90100098 11.72200012 Tm [(MRX99)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.93099976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 207.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 0.75 m 140.55000305 109.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 110.69999695 m 140.55000305 126.29999542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 127.04999542 m 140.55000305 142.6499939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 143.3999939 m 140.55000305 159 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 159.75 m 140.55000305 190.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 191.69999695 m 140.55000305 207.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 207.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 110.32499695 m 422.42498779 110.32499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 126.67499542 m 422.42498779 126.67499542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.0249939 m 422.42498779 143.0249939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 159.375 m 422.42498779 159.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 191.32499695 m 422.42498779 191.32499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 207.67500305 m 423.17498779 207.67500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>