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Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(CDKN)1(2A)] TJ ET EMC /P <</MCID 7 >> BDC BT 1 0 0 -1 98.68900299 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 103.93900299 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 124.93900299 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 130.18899536 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A0006000700080009>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDKN)1(2A)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 98.68900299 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 101.06300354 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 134.26499939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 17 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E0009>] TJ ET EMC /P <</MCID 18 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 24 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<00100009>] TJ ET EMC /P <</MCID 25 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 26 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001100120013>] TJ ET EMC /P <</MCID 27 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 28 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00140015>] TJ ET EMC /P <</MCID 29 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 180.95599365 m 416.75 180.95599365 l 416.75 212.1559906 l -1.45000005 212.1559906 l h f* Q q 1 0 0 1 0 180.95599365 cm /P <</MCID 31 >> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 32 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <</MCID 33 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 240.09500122 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 52.97800064 l -0.75 52.97800064 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 35 >> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Synth)-1(e)1(ti)-1(c)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 34.04399872 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 37.97499847 12.04500008 Tm [(pepti)-1(de)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 66.1969986 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 70.12799835 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 122.91500092 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 126.84600067 12.04500008 Tm [(to)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 134.60699463 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 138.53799438 12.04500008 Tm [(a)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 142.84899902 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 146.77999878 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 170.17199707 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 174.10299683 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 201.78399658 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 205.71499634 12.04500008 Tm [(from)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 223.53500366 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 227.46600342 12.04500008 Tm [(144-1)1(56)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 257.59100342 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 261.52200317 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 284.56298828 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 288.49398804 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 306.92498779 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 310.85598755 12.04500008 Tm [(of)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 318.34899902 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 322.27999878 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 347.96600342 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 351.89700317 12.04500008 Tm [(cy)1(cl)-1(in)-1(-depend)-1(e)1(nt)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 415.28799438 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 0 29.98399925 Tm [(kinas)-1(e)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 23.19400024 29.98399925 Tm [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 25.22900009 29.98399925 Tm [(in)-1(hi)-1(bi)-1(tor)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 56.50899887 29.98399925 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 58.54399872 29.98399925 Tm [(2A)] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 68.31300354 29.98399925 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 51.97800064 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 51.97800064 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 52.22800064 m 426.3500061 52.22800064 l S Q Q q /GS2 gs 1 g -1.45000005 292.57299805 m 416.75 292.57299805 l 416.75 323.77301025 l -1.45000005 323.77301025 l h f* Q q 1 0 0 1 0 292.57299805 cm /P <</MCID 69 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 323.77301025 m 416.75 323.77301025 l 416.75 354.97302246 l -1.45000005 354.97302246 l h f* Q q 1 0 0 1 0 323.77301025 cm /P <</MCID 70 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 71 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 354.97299194 cm /P <</MCID 73 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 382.9119873 cm q /GS2 gs 1 g 0.375 0.75 m 103.77500153 0.75 l 103.77500153 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 104.77500153 -0.25 l 104.77500153 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 74 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 89.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 104.52500153 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 104.52500153 172.3500061 l h f* Q q 1 0 0 1 104.15000153 0 cm -0.625 -0.25 m 319.2749939 -0.25 l 319.2749939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 76 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(gene)-1(r)1(ates)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 90.33000183 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 94.83000183 11.72200012 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 124.73899841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 129.23899841 11.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 170.16099548 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 174.66099548 11.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 208.23100281 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 212.73100281 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 237.82800293 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 242.32800293 11.72200012 Tm [(dif)1(fe)-1(r)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 265.26300049 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 269.76300049 11.72200012 Tm [(in)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 277.70401001 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 282.20401001 11.72200012 Tm [(th)1(e)-1(ir)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 302.0369873 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 306.5369873 11.72200012 Tm [(f)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(irst)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 13.35099983 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 17.85099983 27.3220005 Tm [(exons.)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 45.11899948 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 49.61899948 27.3220005 Tm [(At)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 59.30500031 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 63.80500031 27.3220005 Tm [(least)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 83.80000305 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 88.30000305 27.3220005 Tm [(th)1(re)-1(e)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 110.84400177 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 115.34400177 27.3220005 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 167.86700439 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 172.36700439 27.3220005 Tm [(splice)-1(d)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 202.44799805 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 206.94799805 27.3220005 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 240.51800537 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 245.01800537 27.3220005 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 285.35998535 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 289.85998535 27.3220005 Tm [(dist)1(i)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(nc)-1(t)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 13.4119997 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 17.91200066 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 53.38499832 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 57.88499832 42.92200089 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 78.23200226 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 82.73200226 42.92200089 Tm [(been)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 104.23899841 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 108.73899841 42.92200089 Tm [(repor)1(ted,)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 148.57099915 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 153.07099915 42.92200089 Tm [(tw)1(o)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 169.2519989 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 173.7519989 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 182.59399414 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 187.09399414 42.92200089 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 212.19099426 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 216.69099426 42.92200089 Tm [(en)-1(cod)1(e)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 248.44099426 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 252.94099426 42.92200089 Tm [(st)1(ruc)-1(tura)1(ll)-1(y)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 300.81900024 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 305.31900024 42.92200089 Tm [(r)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(elated)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 26.69199944 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 31.19199944 58.52199936 Tm [(isof)1(orms)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 68.35199738 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 72.85199738 58.52199936 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 101.67099762 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 106.17099762 58.52199936 Tm [(to)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 115.2460022 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 119.7460022 58.52199936 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 155.48699951 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 159.98699951 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 169.12800598 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 173.62800598 58.52199936 Tm [(inhibito)1(rs)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 214.32600403 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 218.82600403 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 227.66799927 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 232.16799927 58.52199936 Tm [(CDK)1(4)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 256.03500366 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 260.53500366 58.52199936 Tm [(ki)-1(na)1(se)-1(.)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 289.78900146 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 294.28900146 58.52199936 Tm [(The)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 310.0960083 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(remainin)-1(g)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 43.5890007 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 48.0890007 74.12200165 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 89.01100159 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 93.51100159 74.12200165 Tm [(inc)-1(ludes)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 128.93499756 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 133.43499756 74.12200165 Tm [(an)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 143.95599365 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 148.45599365 74.12200165 Tm [(alt)1(e)-1(rnat)1(e)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 186.70199585 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 191.20199585 74.12200165 Tm [(first)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 207.67300415 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 212.17300415 74.12200165 Tm [(exon)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 233.10899353 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 237.60899353 74.12200165 Tm [(located)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 269.42999268 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 273.92999268 74.12200165 Tm [(20)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 284.48599243 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 288.98599243 74.12200165 Tm [(Kb)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 300.44699097 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 304.94699097 74.12200165 Tm [(u)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(pst)1(ream)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 35.2179985 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 39.7179985 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 48.56000137 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 53.06000137 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 67.06099701 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 71.56099701 89.72200012 Tm [(remainder)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 115.7519989 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 120.2519989 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 129.09399414 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 133.59399414 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 147.59500122 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 152.09500122 89.72200012 Tm [(gene)-1(;)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 175.7769928 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 180.2769928 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 195.73300171 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 200.23300171 89.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 241.15499878 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 245.65499878 89.72200012 Tm [(contains)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 281.86999512 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 286.36999512 89.72200012 Tm [(an)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 296.89099121 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 301.39099121 89.72200012 Tm [(al)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ternat)1(e)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 30.87599945 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 35.37599945 105.3219986 Tm [(op)1(e)-1(n)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 57.4980011 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 61.9980011 105.3219986 Tm [(reading)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 94.97000122 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 99.47000122 105.3219986 Tm [(fra)1(me)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 124.54100037 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 129.04100037 105.3219986 Tm [(\(AR)1(F)-1(\))] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 152.04200745 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 156.54200745 105.3219986 Tm [(th)1(at)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 173.76400757 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 178.26400757 105.3219986 Tm [(speci)-1(f)1(ie)-1(s)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 214.97999573 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 219.47999573 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 224.45500183 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 228.95500183 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 260.26199341 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 264.76199341 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 289.85900879 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 294.35900879 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 300.92001343 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 305.42001343 105.3219986 Tm [(s)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(tr)1(u)-1(ctura)1(l)-1(ly)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 43.7120018 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 48.2120018 120.92199707 Tm [(unre)-1(la)1(ted)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 89.43299866 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 93.93299866 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 103.00800323 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 107.50800323 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 121.50900269 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 126.00900269 120.92199707 Tm [(pro)1(duc)-1(t)1(s)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 164.25 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 168.75 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 177.59199524 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 182.09199524 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 196.09300232 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 200.59300232 120.92199707 Tm [(ot)1(her)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 223.7519989 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 228.2519989 120.92199707 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 263.98800659 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 268.48800659 120.92199707 Tm [(This)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 285.75 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 290.25 120.92199707 Tm [(AR)1(F)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 307.23901367 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 34.07500076 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 38.57500076 136.52200317 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 78.48200226 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 82.98200226 136.52200317 Tm [(as)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 92.1230011 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 96.6230011 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 101.59799957 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 106.09799957 136.52200317 Tm [(st)1(abilizer)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 144.49299622 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 148.99299622 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 157.83500671 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 162.33500671 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 176.33599854 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 180.83599854 136.52200317 Tm [(tumor)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 207.32600403 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 211.82600403 136.52200317 Tm [(supp)1(re)-1(ss)1(or)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 259.06698608 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 263.56698608 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 294.87399292 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 299.37399292 136.52200317 Tm [(p5)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(3)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 5.27799988 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 9.77799988 152.12199402 Tm [(as)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 18.91900063 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 23.41900063 152.12199402 Tm [(it)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 29.16699982 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 33.66699982 152.12199402 Tm [(can)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 48.70100021 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 53.20100021 152.12199402 Tm [(interact)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 85.8789978 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 90.3789978 152.12199402 Tm [(wit)1(h,)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 110.94100189 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 115.44100189 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 131.71800232 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 136.21800232 152.12199402 Tm [(seque)-1(s)1(ter,)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 180.12800598 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 184.62800598 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 198.6289978 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 203.1289978 152.12199402 Tm [(E3)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 213.35499573 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 217.85499573 152.12199402 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 291.73599243 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 296.23599243 152.12199402 Tm [(lig)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ase)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 14.24699974 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 18.74699974 167.72200012 Tm [(MDM2,)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 50.63399887 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 55.13399887 167.72200012 Tm [(a)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 60.10900116 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 64.60900116 167.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 95.91600037 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 100.41600037 167.72200012 Tm [(responsib)1(l)-1(e)] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 149.95100403 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 154.45100403 167.72200012 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 166.72900391 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 171.22900391 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 185.22999573 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 189.72999573 167.72200012 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 242.50799561 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 247.00799561 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 255.8500061 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 260.3500061 167.72200012 Tm [(p53)-1(.)] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 278.82000732 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 172.3500061 cm q /GS2 gs 1 g 0.375 0.75 m 103.77500153 0.75 l 103.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 104.77500153 -0.25 l 104.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 312 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 314 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n)] TJ ET EMC /P <</MCID 315 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 72.29399872 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 104.52500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 104.52500153 16.35000038 l h f* Q q 1 0 0 1 104.15000153 0 cm -0.625 -0.25 m 319.2749939 -0.25 l 319.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 316 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NP_00)-1(00)-1(68)] TJ ET EMC /P <</MCID 317 >> BDC BT 1 0 0 -1 48.52399826 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 188.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 103.77500153 0.75 l 103.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 104.77500153 -0.25 l 104.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 318 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot)] TJ ET EMC /P <</MCID 319 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 44.07699966 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 104.52500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 104.52500153 16.35000038 l h f* Q q 1 0 0 1 104.15000153 0 cm -0.625 -0.25 m 319.2749939 -0.25 l 319.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 320 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P42)-1(77)-1(1)] TJ ET EMC /P <</MCID 321 >> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 205.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 103.77500153 0.75 l 103.77500153 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 104.77500153 -0.25 l 104.77500153 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 322 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Synonyms)] TJ ET EMC /P <</MCID 323 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.60800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 104.52500153 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 104.52500153 31.95000076 l h f* Q q 1 0 0 1 104.15000153 0 cm -0.625 -0.25 m 319.2749939 -0.25 l 319.2749939 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 324 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(AR)1(F)-1(;)] TJ ET EMC /P <</MCID 325 >> BDC BT 1 0 0 -1 19.15600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 326 >> BDC BT 1 0 0 -1 23.65600014 11.72200012 Tm [(MLM;)] TJ ET EMC /P <</MCID 327 >> BDC BT 1 0 0 -1 48.02799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 328 >> BDC BT 1 0 0 -1 52.52799988 11.72200012 Tm [(P14)-1(;)] TJ ET EMC /P <</MCID 329 >> BDC BT 1 0 0 -1 70.75700378 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 330 >> BDC BT 1 0 0 -1 75.25700378 11.72200012 Tm [(P16)-1(;)] TJ ET EMC /P <</MCID 331 >> BDC BT 1 0 0 -1 93.48600006 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 332 >> BDC BT 1 0 0 -1 97.98600006 11.72200012 Tm [(P19)-1(;)] TJ ET EMC /P <</MCID 333 >> BDC BT 1 0 0 -1 116.21499634 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 334 >> BDC BT 1 0 0 -1 120.71499634 11.72200012 Tm [(CMM2;)] TJ ET EMC /P <</MCID 335 >> BDC BT 1 0 0 -1 151.76699829 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 336 >> BDC BT 1 0 0 -1 156.26699829 11.72200012 Tm [(INK4;)] TJ ET EMC /P <</MCID 337 >> BDC BT 1 0 0 -1 179.38699341 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 338 >> BDC BT 1 0 0 -1 183.88699341 11.72200012 Tm [(MTS1)-1(;)] TJ ET EMC /P <</MCID 339 >> BDC BT 1 0 0 -1 210.47799683 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 340 >> BDC BT 1 0 0 -1 214.97799683 11.72200012 Tm [(TP16)-1(;)] TJ ET EMC /P <</MCID 341 >> BDC BT 1 0 0 -1 238.36599731 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 342 >> BDC BT 1 0 0 -1 242.86599731 11.72200012 Tm [(CDK)1(4)-1(I;)] TJ ET EMC /P <</MCID 343 >> BDC BT 1 0 0 -1 271.54501343 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 344 >> BDC BT 1 0 0 -1 276.04501343 11.72200012 Tm [(CDK)1(N2)-1(;)] TJ ET EMC /P <</MCID 345 >> BDC BT 1 0 0 -1 309.39498901 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 346 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(INK4A;)] TJ ET EMC /P <</MCID 347 >> BDC BT 1 0 0 -1 29.45199966 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 348 >> BDC BT 1 0 0 -1 33.95199966 27.3220005 Tm [(MTS-1;)] TJ ET EMC /P <</MCID 349 >> BDC BT 1 0 0 -1 64.43699646 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 350 >> BDC BT 1 0 0 -1 68.93699646 27.3220005 Tm [(P14)-1(A)1(RF;)] TJ ET EMC /P <</MCID 351 >> BDC BT 1 0 0 -1 104.15499878 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 352 >> BDC BT 1 0 0 -1 108.65499878 27.3220005 Tm [(P19)-1(A)1(RF;)] TJ ET EMC /P <</MCID 353 >> BDC BT 1 0 0 -1 143.8730011 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 354 >> BDC BT 1 0 0 -1 148.3730011 27.3220005 Tm [(P16)-1(INK)1(4)-1(;)] TJ ET EMC /P <</MCID 355 >> BDC BT 1 0 0 -1 187.55499268 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 356 >> BDC BT 1 0 0 -1 192.05499268 27.3220005 Tm [(P16)-1(INK)1(4)-1(A)1(;)] TJ ET EMC /P <</MCID 357 >> BDC BT 1 0 0 -1 237.56900024 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 358 >> BDC BT 1 0 0 -1 242.06900024 27.3220005 Tm [(P16)-1(-)1(INK4A)] TJ ET EMC /P <</MCID 359 >> BDC BT 1 0 0 -1 289.30999756 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 237.00001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 104.15000153 0.75 m 104.15000153 172.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 104.15000153 173.1000061 m 104.15000153 188.70001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 104.15000153 189.45001221 m 104.15000153 205.05001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 104.15000153 205.80001831 m 104.15000153 237.00001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 237.00001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 172.7250061 m 422.42498779 172.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 189.07501221 m 422.42498779 189.07501221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 205.42501831 m 422.42498779 205.42501831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 237.37501526 m 423.17498779 237.37501526 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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