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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 88 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(US)1(B1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 125.50700378 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 235.94700623 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(USB1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 111.84400177 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 164.34399414 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.59399414 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(U)1(S)-1(B1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.32800293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.70200348 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.47399902 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.8480072 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.16900635 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.54299927 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.33900452 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(U6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.05899811 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.43299866 12.82499981 Tm [(sn)-1(R)1(NA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.61100006 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.98500061 12.82499981 Tm [(bi)-1(oge)1(n)-1(e)1(s)-1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.97900391 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.35299683 12.82499981 Tm [(ph)-1(osp)-1(hod)-1(ieste)1(rase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.61999512 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.9940033 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.125 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.49899292 12.82499981 Tm [(PN)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.51098633 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.88500977 12.82499981 Tm [(Mpn)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.02700806 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.40100098 12.82499981 Tm [(HVS)-1(L1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 327.27099609 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 329.64498901 12.82499981 Tm [(hUsb1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 359.65301514 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 362.02700806 12.82499981 Tm [(C16orf57)] TJ ET EMC /P <> BDC BT 1 0 0 -1 401.31500244 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(USB1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.59400177 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002300240025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 140.92500305 156.75 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.8730011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.3730011 11.72200012 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.28199768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.78199768 11.72200012 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.85899353 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.35899353 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.33300018 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.83300018 27.3220005 Tm [(ho)1(weve)-1(r,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.74200058 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.24200058 27.3220005 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.15599823 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.65599823 27.3220005 Tm [(exact)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.16500092 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.66500092 27.3220005 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.40600586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.90600586 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.46699524 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.96699524 27.3220005 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.58799744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.08799744 27.3220005 Tm [(kn)-1(o)1(wn.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.07400513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.57400513 27.3220005 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.42300415 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.92300415 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.86401367 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.36401367 27.3220005 Tm [(th)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 42.92200089 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.18199921 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.68199921 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.20000076 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.70000076 42.92200089 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.82700348 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.32700348 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.72299957 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.22299957 42.92200089 Tm [(po)1(i)-1(kiloderma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.20700073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.70700073 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.10299683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.60299683 42.92200089 Tm [(ne)-1(ut)1(ropenia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.08200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.58200073 42.92200089 Tm [(\()] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(PN\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.99600029 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.49600029 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.5929985 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.0929985 58.52199936 Tm [(sho)1(ws)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.79399872 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.29399872 58.52199936 Tm [(ph)1(e)-1(not)1(y)-1(p)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.73100281 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.23100281 58.52199936 Tm [(overlap)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.33700562 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.83700562 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.23300171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.73300171 58.52199936 Tm [(Rot)1(hmund-Tho)1(ms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.26799965 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.76799965 74.12200165 Tm [(syndrome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.69800186 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.19800186 74.12200165 Tm [(\(RTS\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.43900299 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.93900299 74.12200165 Tm [(cause)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.0019989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.5019989 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.01400757 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.51400757 74.12200165 Tm [(mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.0019989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.5019989 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.44299316 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.94299316 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.94400024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.44400024 74.12200165 Tm [(RECQL4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.51899719 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.01901245 74.12200165 Tm [(gen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(e.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.27299976 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.77299976 89.72200012 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.77199936 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.27199936 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.83300018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.33300018 89.72200012 Tm [(belie)-1(ved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.67099762 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.17099762 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.39299774 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.89299774 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.34899902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.84899902 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.36500549 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.86500549 89.72200012 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.94000244 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.44000244 89.72200012 Tm [(interacts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.28399658 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.78399658 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.17999268 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.67999268 89.72200012 Tm [(RECQL)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.27799988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.77799988 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.08499908 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.58499908 105.3219986 Tm [(via)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.67900085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.17900085 105.3219986 Tm [(SMAD4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.63300323 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.13300323 105.3219986 Tm [(pro)1(tein)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.77200317 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.27200317 105.3219986 Tm [(explaining)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.69599915 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.19599915 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.19700623 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.69700623 105.3219986 Tm [(pa)1(rtial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.97399902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.47399902 105.3219986 Tm [(cl)-1(inical)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.60101318 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(overlap)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 120.92199707 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.6780014 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.1780014 120.92199707 Tm [(PN)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.00099945 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.50099945 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.77799988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.27799988 120.92199707 Tm [(RTS.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.67399597 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.17399597 120.92199707 Tm [(Alt)1(e)-1(rna)1(tivel)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.05499268 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.55499268 120.92199707 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.63600159 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.13600159 120.92199707 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.05801392 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.56999969 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.06999969 136.52200317 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.41200256 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.91200256 136.52200317 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.85199738 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.35199738 136.52200317 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.51199341 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.01199341 136.52200317 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.35899353 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.85899353 136.52200317 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.36599731 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.86599731 136.52200317 Tm [(noted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.3500061 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.8500061 136.52200317 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.12799072 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.62799072 136.52200317 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.56099987 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.06099987 152.12199402 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.74300003 152.12199402 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 156.75 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 173.1000061 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(USB1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.83799934 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 189.44999695 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(USB1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.18400574 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 205.80001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 0.75 m 140.55000305 156.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 157.5 m 140.55000305 173.1000061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 173.8500061 m 140.55000305 189.45001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 190.20001221 m 140.55000305 205.80001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 205.80001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.125 m 422.42498779 157.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 173.4750061 m 422.42498779 173.4750061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 189.82501221 m 422.42498779 189.82501221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 206.17501831 m 423.17498779 206.17501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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