%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 111 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 271 0 0 -90.45000458 0 90.45000458 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.70200348 23.67700005 Tm 0 g [(CD)-1(H1)1(9)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 152.89399719 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 329.59799194 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(CDH19)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.9940033 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 92.2440033 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 176.2440033 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDH19)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.2440033 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.61799622 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.81999969 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.19400024 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.17399597 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.54800415 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.02200317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0012000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0015000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0016>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(cadh)-1(e)1(rin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.31400299 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.68800354 12.82499981 Tm [(19;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.14099884 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.51499939 12.82499981 Tm [(CDH7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.24699402 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.6210022 12.82499981 Tm [(CDH7L)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.27900696 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 236.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 282.71200562 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(246-4)1(45)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(CDH19\\)] TJ ET EMC /P <> BDC BT 1 0 0 -1 344.34799194 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 311.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 339.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 367.5289917 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 395.46798706 cm q /GS2 gs 1 g 0.375 0.75 m 117.22499847 0.75 l 117.22499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 118.22499847 -0.25 l 118.22499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.97499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 117.97499847 16.35000038 l h f* Q q 1 0 0 1 117.59999847 0 cm -0.625 -0.25 m 309.57501221 -0.25 l 309.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(cadherin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.27000046 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.77000046 11.72200012 Tm [(19)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.32600021 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 117.22499847 0.75 l 117.22499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 118.22499847 -0.25 l 118.22499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.97499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 117.97499847 16.35000038 l h f* Q q 1 0 0 1 117.59999847 0 cm -0.625 -0.25 m 309.57501221 -0.25 l 309.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CDH7)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.28100014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.78100014 11.72200012 Tm [(CDH7)-1(L2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.79199982 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 117.22499847 0.75 l 117.22499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 118.22499847 -0.25 l 118.22499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.97499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 117.97499847 16.35000038 l h f* Q q 1 0 0 1 117.59999847 0 cm -0.625 -0.25 m 309.57501221 -0.25 l 309.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q9H)-1(15)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.4070015 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 117.22499847 0.75 l 117.22499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 118.22499847 -0.25 l 118.22499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.97499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 117.97499847 16.35000038 l h f* Q q 1 0 0 1 117.59999847 0 cm -0.625 -0.25 m 309.57501221 -0.25 l 309.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(15)-1(87)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 117.22499847 0.75 l 117.22499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 118.22499847 -0.25 l 118.22499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.97499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 117.97499847 16.35000038 l h f* Q q 1 0 0 1 117.59999847 0 cm -0.625 -0.25 m 309.57501221 -0.25 l 309.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 117.22499847 0.75 l 117.22499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 118.22499847 -0.25 l 118.22499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.97499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 117.97499847 16.35000038 l h f* Q q 1 0 0 1 117.59999847 0 cm -0.625 -0.25 m 309.57501221 -0.25 l 309.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 117.22499847 0.75 l 117.22499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 118.22499847 -0.25 l 118.22499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.97499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 117.97499847 16.35000038 l h f* Q q 1 0 0 1 117.59999847 0 cm -0.625 -0.25 m 309.57501221 -0.25 l 309.57501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 117.22499847 0.75 l 117.22499847 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 118.22499847 -0.25 l 118.22499847 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 117.97499847 0.75 m 426.17501831 0.75 l 426.17501831 94.34999847 l 117.97499847 94.34999847 l h f* Q q 1 0 0 1 117.59999847 0 cm -0.625 -0.25 m 309.57501221 -0.25 l 309.57501221 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3390007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.8390007 11.72200012 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.21299744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.71299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.55500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.05500031 11.72200012 Tm [(th)1(re)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.59899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.09899902 11.72200012 Tm [(related)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.22799683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.72799683 11.72200012 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.69900513 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.19900513 11.72200012 Tm [(II)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.49000549 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.99000549 11.72200012 Tm [(cadherin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.25999451 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.75999451 11.72200012 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.44200134 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.94198608 11.72200012 Tm [(situat)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.59298706 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.41600037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.91600037 27.3220005 Tm [(cl)-1(ust)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.43199921 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.93199921 27.3220005 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.19999695 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.69999695 27.3220005 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.49500275 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.99499512 27.3220005 Tm [(18)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.71699524 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.21699524 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.02400208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.52400208 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.03100586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.53100586 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.83799744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.33799744 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.89900208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.39898682 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.37399292 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.87399292 27.3220005 Tm [(calc)-1(ium)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.64401245 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(dependen)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.02600098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.52600098 42.92200089 Tm [(ce)-1(ll-ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.23899841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.73899841 42.92200089 Tm [(ad)1(hesion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.9469986 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.44700623 42.92200089 Tm [(glyc)-1(o)1(prot)1(ei)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.90400696 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.40400696 42.92200089 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.15100098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.65100098 42.92200089 Tm [(five)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.99700928 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.49700928 42.92200089 Tm [(extra)1(c)-1(ell)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.35199928 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.85199928 58.52199936 Tm [(cadherin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.12200165 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.62200165 58.52199936 Tm [(repeats)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.68000031 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.18000031 58.52199936 Tm [(Loss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.85199738 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.35199738 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.19400024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.69400024 58.52199936 Tm [(cadherins)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.13000488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.63000488 58.52199936 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.80099487 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.30099487 58.52199936 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.15499878 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.65499878 58.52199936 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.78201294 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.28201294 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.67800903 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.17800903 58.52199936 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ance)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.57699966 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.07699966 74.12200165 Tm [(fo)1(rmatio)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.94499969 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.44499969 74.12200165 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.16799927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.66799927 74.12200165 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.58299255 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.08299255 74.12200165 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.2519989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.7519989 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.69299316 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.19299316 74.12200165 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.56500244 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.06500244 74.12200165 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.98699951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.48699951 74.12200165 Tm [(v)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(aria)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.84600067 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.34600067 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.62400055 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.12400055 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.58000183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.08000183 89.72200012 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.76200104 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 117.59999847 0.75 m 117.59999847 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 117.59999847 17.10000038 m 117.59999847 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 117.59999847 33.45000076 m 117.59999847 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 117.59999847 49.80000305 m 117.59999847 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 117.59999847 66.15000153 m 117.59999847 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 117.59999847 82.5 m 117.59999847 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 117.59999847 98.84999847 m 117.59999847 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 117.59999847 115.19999695 m 117.59999847 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17501831 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92501831 209.17498779 l S Q Q q 1 0 0 1 0 605.01800537 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>