%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 140 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 66 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(UQCRC1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 153.54400635 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 263.98400879 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.98400879 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.68499756 12.82499981 Tm [(UQ)1(C)-1(RC1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 133.33200073 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 185.83200073 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.08200073 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(U)1(QCRC1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.75499725 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.1289978 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.90100098 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.2749939 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.59599304 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.97000122 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.76600647 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(D3S)-1(3)1(191;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.70300293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.07700348 12.82499981 Tm [(QCR1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.57299805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.9469986 12.82499981 Tm [(UQ)1(C)-1(R1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.36999512 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(UQ)1(C)-1(RC1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.02200317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 113.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.36000061 12.82499981 Tm [(Do)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.2990036 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.67299652 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.29299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.66699982 12.82499981 Tm [(Rat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.91499329 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.28900146 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.90899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.28300476 12.82499981 Tm [(Mon)-1(k)1(ey)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.06399536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.43800354 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.05799866 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.43200684 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.79400635 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002000210022000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800220027>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 105.3219986 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 143.17500305 203.55000305 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(UQC)1(RC1)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.41500092 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.91500092 11.72200012 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.07300186 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.57300186 11.72200012 Tm [(Ub)1(iquin)-1(o)1(l-cy)-1(t)1(oc)-1(h)1(rome-c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.19999695 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.69999695 11.72200012 Tm [(reduc)-1(t)1(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.65899658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.15899658 11.72200012 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.63800049 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.13800049 11.72200012 Tm [(cor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.9129982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.4129982 27.3220005 Tm [(1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85699844 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.35699844 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.91799927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.41799927 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.39299774 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.89299774 27.3220005 Tm [(core)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.67099762 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.17099762 27.3220005 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.47099304 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.97099304 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.81300354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.31300354 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.31399536 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.81399536 27.3220005 Tm [(mito)1(c)-1(ho)1(n)-1(d)1(rial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.99699402 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.49699402 27.3220005 Tm [(respira)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.92199993 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.42200089 42.92200089 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.90100098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.40100098 42.92200089 Tm [(III.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.5039978 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.0039978 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.00299835 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.50299835 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.06400299 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.56400299 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.56500244 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.06500244 42.92200089 Tm [(larg)1(e)-1(st)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.25300598 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.75300598 42.92200089 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.27099609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.77099609 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.27799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.77799988 42.92200089 Tm [(subunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.07800293 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.57800293 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.42001343 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 58.52199936 Tm [(complex.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.14699936 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.64699936 58.52199936 Tm [(UQC)1(RC1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.89499664 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.39499664 58.52199936 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.44200134 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.94200134 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.91700745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.41700745 58.52199936 Tm [(ke)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.18699646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.68699646 58.52199936 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.34700012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.84700012 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.78799438 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.28799438 58.52199936 Tm [(mito)1(c)-1(ho)1(n)-1(d)1(ria-t)1(o-)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(uc)-1(leus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.27199936 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.77199936 74.12200165 Tm [(retro)1(grad)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.85700226 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.35700226 74.12200165 Tm [(response)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.35399628 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85399628 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.1309967 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.6309967 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.19200134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.69200134 74.12200165 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.06100464 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.56100464 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.5019989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.0019989 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.00300598 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.50300598 74.12200165 Tm [(mito)1(c)-1(ho)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(dr)1(i)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.95800018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.45800018 89.72200012 Tm [(pro)1(ton)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.98500061 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.48500061 89.72200012 Tm [(gr)1(adien)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.80999756 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.30999756 89.72200012 Tm [(fo)1(rmatio)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.17799377 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.67799377 89.72200012 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.67700195 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.17700195 89.72200012 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.85899353 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.35899353 89.72200012 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.61599731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.11599731 89.72200012 Tm [(sho)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.19700623 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.69700623 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.77200317 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.27200317 89.72200012 Tm [(intera)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ct)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.86600018 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.36600018 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.76199913 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.26200104 105.3219986 Tm [(Nog)1(o,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.94599915 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.44599915 105.3219986 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.96700287 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.46700287 105.3219986 Tm [(inhibito)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.99900055 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.49900055 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.34100342 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.84100342 105.3219986 Tm [(ne)-1(urit)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.33000183 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.83000183 105.3219986 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.7460022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.2460022 105.3219986 Tm [(af)1(ter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.23699951 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.73699951 105.3219986 Tm [(spinal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.96200562 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.46200562 105.3219986 Tm [(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(rd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.19299984 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.69299984 120.92199707 Tm [(inju)-1(r)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.95000076 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.45000076 120.92199707 Tm [(UQC)1(RC1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.69799805 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.19799805 120.92199707 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.87999725 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.37999725 120.92199707 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.88700104 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.38699341 120.92199707 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.07699585 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.57699585 120.92199707 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.90499878 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.40499878 120.92199707 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.63999939 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.13999939 120.92199707 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.09399414 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.59399414 120.92199707 Tm [(leve)-1(ls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.48699951 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 136.52200317 Tm [(breast)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.22600174 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.72600174 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.00299835 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.50299835 136.52200317 Tm [(ova)1(rian)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.27500153 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.77500153 136.52200317 Tm [(tumor)1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.5980072 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.0980072 136.52200317 Tm [(po)1(sitively)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.86599731 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.36599731 136.52200317 Tm [(correlating)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.00100708 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.50100708 136.52200317 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.89700317 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.39700317 136.52200317 Tm [(Co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(x-)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.7329998 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.2329998 152.12199402 Tm [(expression.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.35299683 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.85299683 152.12199402 Tm [(Transcriptio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.2440033 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.7440033 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.58599854 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.08599854 152.12199402 Tm [(UQC)1(RC1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.33399963 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.83399963 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.39500427 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.89500427 152.12199402 Tm [(repressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.92399597 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.42399597 152.12199402 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.93600464 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.43600464 152.12199402 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 167.72200012 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.12400055 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.62400055 167.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.93099976 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.43099976 167.72200012 Tm [(methyl-Cp)1(G-b)1(in)-1(d)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.41600037 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.91600037 167.72200012 Tm [(pro)1(tein)-1(-)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.39399719 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.89399719 167.72200012 Tm [(\(MeCP2)-1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.77700806 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.27700806 167.72200012 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.60998535 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(mutat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.3219986 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.8219986 183.32200623 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.76300049 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.26300049 183.32200623 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.26399994 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.76399994 183.32200623 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.27999878 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.77999878 183.32200623 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.05799866 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.55799866 183.32200623 Tm [(MeCP2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.26300049 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.76300049 183.32200623 Tm [(\(asso)1(c)-1(iat)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.89599609 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.39599609 183.32200623 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.79200745 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.29200745 183.32200623 Tm [(Rett)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.97999573 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.47999573 183.32200623 Tm [(synd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(rome\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.70400047 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.20400047 198.92199707 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.23799896 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.73799896 198.92199707 Tm [(result)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.74099731 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.24099731 198.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.18199921 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.68199921 198.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.68299866 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.18299866 198.92199707 Tm [(overexpression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.125 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.625 198.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.46699524 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.96699524 198.92199707 Tm [(UQC)1(RC1)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.38200378 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.88200378 198.92199707 Tm [(leading)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.81298828 198.92199707 Tm [( )] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 0.75 m 142.80000305 203.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>