%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 110 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 85.70200348 23.67700005 Tm 0 g [(CD)-1(H1)1(6)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 152.89399719 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 329.59799194 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(CDH16)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.2440033 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 97.4940033 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 181.4940033 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CDH16)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.2440033 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.61799622 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.81999969 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.19400024 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.17399597 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.54800415 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.02200317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(cadh)-1(e)1(rin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.31400299 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.68800354 12.82499981 Tm [(16)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.33200073 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.85800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 236.83399963 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 282.71200562 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(630-8)1(29)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(CDH16)] TJ ET EMC /P <> BDC BT 1 0 0 -1 340.87200928 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 311.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 339.58999634 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 367.5289917 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 395.46798706 cm q /GS2 gs 1 g 0.375 0.75 m 89.97499847 0.75 l 89.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 90.97499847 -0.25 l 90.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 90.72499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 90.72499847 16.35000038 l h f* Q q 1 0 0 1 90.34999847 0 cm -0.625 -0.25 m 336.82501221 -0.25 l 336.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(cadherin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.27000046 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.77000046 11.72200012 Tm [(16)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.32600021 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 89.97499847 0.75 l 89.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 90.97499847 -0.25 l 90.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 90.72499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 90.72499847 16.35000038 l h f* Q q 1 0 0 1 90.34999847 0 cm -0.625 -0.25 m 336.82501221 -0.25 l 336.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(O75)-1(30)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.72399902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 89.97499847 0.75 l 89.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 90.97499847 -0.25 l 90.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 90.72499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 90.72499847 16.35000038 l h f* Q q 1 0 0 1 90.34999847 0 cm -0.625 -0.25 m 336.82501221 -0.25 l 336.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(27)-1(91)-1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 89.97499847 0.75 l 89.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 90.97499847 -0.25 l 90.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 90.72499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 90.72499847 16.35000038 l h f* Q q 1 0 0 1 90.34999847 0 cm -0.625 -0.25 m 336.82501221 -0.25 l 336.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 89.97499847 0.75 l 89.97499847 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 90.97499847 -0.25 l 90.97499847 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(syste)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(m:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 11.40799999 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 90.72499847 0.75 m 426.17501831 0.75 l 426.17501831 31.95000076 l 90.72499847 31.95000076 l h f* Q q 1 0 0 1 90.34999847 0 cm -0.625 -0.25 m 336.82501221 -0.25 l 336.82501221 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 19.52199936 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 89.97499847 0.75 l 89.97499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 90.97499847 -0.25 l 90.97499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 90.72499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 90.72499847 16.35000038 l h f* Q q 1 0 0 1 90.34999847 0 cm -0.625 -0.25 m 336.82501221 -0.25 l 336.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 89.97499847 0.75 l 89.97499847 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 90.97499847 -0.25 l 90.97499847 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 90.72499847 0.75 m 426.17501831 0.75 l 426.17501831 109.94999695 l 90.72499847 109.94999695 l h f* Q q 1 0 0 1 90.34999847 0 cm -0.625 -0.25 m 336.82501221 -0.25 l 336.82501221 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.3390007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.8390007 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.81399918 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.31400299 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.57800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.07800293 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.91999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.41999817 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.42100525 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.92100525 11.72200012 Tm [(cadherin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.19099426 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.69099426 11.72200012 Tm [(superfa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.94200134 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.44200134 11.72200012 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.12399292 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.62399292 11.72200012 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.96600342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.46600342 11.72200012 Tm [(cal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ci)-1(um-)1(depe)-1(nd)1(e)-1(nt,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.97299957 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.47299957 27.3220005 Tm [(membrane-as)1(soc)-1(ia)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.27799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.77799988 27.3220005 Tm [(glyc)-1(o)1(prot)1(ei)-1(ns.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.56799316 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.06799316 27.3220005 Tm [(Map)1(pe)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.19500732 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.69500732 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.76998901 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.26998901 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.24499512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.74499512 27.3220005 Tm [(prev)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(iously)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.98699951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.48699951 42.92200089 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.41799927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.91799927 42.92200089 Tm [(cl)-1(ust)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.43399811 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.93399811 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.77600098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.27600098 42.92200089 Tm [(cadherin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.54600525 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.04600525 42.92200089 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.72799683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.22799683 42.92200089 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.4960022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.9960022 42.92200089 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.79098511 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.29098511 42.92200089 Tm [(16)-1(q22.1)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.76998901 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.26998901 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.27099609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.51600075 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.01600075 58.52199936 Tm [(localizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.10800171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.60800171 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.0039978 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.5039978 58.52199936 Tm [(superfa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.58799744 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.08799744 58.52199936 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.51800537 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.01800537 58.52199936 Tm [(CDH1)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.29899597 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.79899597 58.52199936 Tm [(CDH3)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.08000183 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.58000183 58.52199936 Tm [(CDH5)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.86099243 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.36099243 58.52199936 Tm [(CDH8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.47601318 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.97601318 58.52199936 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 74.12200165 Tm [(CDH1)-1(1.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.81600189 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.31600189 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.1230011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.6230011 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.93000031 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.43000031 74.12200165 Tm [(consists)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.45700073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.95700073 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.79899597 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.29899597 74.12200165 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.82000732 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.32000732 74.12200165 Tm [(extra)1(c)-1(ellu)-1(la)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.51400757 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.01400757 74.12200165 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.84100342 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.34100342 74.12200165 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.0880127 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.5880127 74.12200165 Tm [(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 319.86599731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(cadherin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.27000046 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.77000046 89.72200012 Tm [(do)1(mains,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.93000031 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.43000031 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.40499878 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.90499878 89.72200012 Tm [(tr)1(ansme)-1(mb)1(rane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.16499329 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.66499329 89.72200012 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.6269989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.1269989 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.40400696 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.90400696 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.8789978 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.3789978 89.72200012 Tm [(tr)1(u)-1(ncated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.96398926 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.46398926 89.72200012 Tm [(cy)-1(t)1(oplas)1(mi)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 327.44100952 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.82699966 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.32699966 105.3219986 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.97399902 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.47399902 105.3219986 Tm [(lack)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.42299652 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.92299652 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.9240036 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.4240036 105.3219986 Tm [(pro)1(se)-1(q)1(ue)-1(nce)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.17700195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.67700195 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.95399475 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.45399475 105.3219986 Tm [(tr)1(i)-1(p)1(e)-1(p)1(tide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.852005 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.352005 105.3219986 Tm [(HAV)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.73199463 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.23199463 105.3219986 Tm [(ad)1(hesion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.44000244 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.94000244 105.3219986 Tm [(rec)-1(o)1(gni)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 223.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 90.34999847 0.75 m 90.34999847 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 90.34999847 17.10000038 m 90.34999847 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 90.34999847 33.45000076 m 90.34999847 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 90.34999847 49.80000305 m 90.34999847 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 90.34999847 66.15000153 m 90.34999847 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 90.34999847 98.1000061 m 90.34999847 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 90.34999847 114.45000458 m 90.34999847 223.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 223.6499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17501831 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17501831 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.0249939 m 426.92501831 224.0249939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>