%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 133 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 66 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(UPRT)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 126.61399841 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 237.05400085 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(UP)1(RT)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 122.72899628 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.22900391 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.47900391 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(U)1(PRT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.71199799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.08599854 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.85800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.23199463 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.55299377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.92700195 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.7230072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(uracil)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.46600342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.83999634 12.82499981 Tm [(ph)-1(osp)-1(horib)-1(osyltrans)-1(fe)1(rase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.76100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.13499451 12.82499981 Tm [(ho)-1(molo)-1(g)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.81199646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.18600464 12.82499981 Tm [(UP)1(P;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.58099365 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.95498657 12.82499981 Tm [(FUR1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.53900146 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UP)1(RT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.97899628 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 140.92500305 125.55000305 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(uracil)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.45500183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.95500183 11.72200012 Tm [(ph)1(osph)1(oribos)1(y)-1(lt)1(ransferase,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.32200623 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.82200623 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.91900635 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.41900635 11.72200012 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(at)1(alyze)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.1590004 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.6590004 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.65999985 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.15999985 27.3220005 Tm [(conve)-1(rs)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.03600311 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.53600311 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.37799835 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.87799835 27.3220005 Tm [(uracil)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.13800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.63800049 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.91499329 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.41499329 27.3220005 Tm [(5-ph)1(osph)1(oribos)1(y)-1(l-)1(1)-1(-R)1(-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(dip)1(hosp)1(hat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.0530014 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.5530014 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.62799835 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.12799835 42.92200089 Tm [(uridine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.30999756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.80999756 42.92200089 Tm [(monop)1(hosp)1(hat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.13299561 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.63299561 42.92200089 Tm [(\(UMP)1(\).)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.83000183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.33000183 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.59199524 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.09199524 42.92200089 Tm [(reaction)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.13800049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.56099987 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.06099987 58.52199936 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.58200073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.08200073 58.52199936 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.04299927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.54299927 58.52199936 Tm [(pa)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.05500031 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.55500031 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.39700317 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.89700317 58.52199936 Tm [(nuc)-1(leotid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.33599854 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.83599854 58.52199936 Tm [(metab)1(olism,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.72900391 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.22900391 58.52199936 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.71398926 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.21398926 58.52199936 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(he)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.64799976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.14799976 74.12200165 Tm [(pyrimidine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.12400055 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.62400055 74.12200165 Tm [(salva)1(ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.72200012 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.22200012 74.12200165 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.8500061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.3500061 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.15699768 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.65699768 74.12200165 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.03799438 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.53799438 74.12200165 Tm [(localizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.63000488 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.13000488 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.20500183 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.70498657 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.70599365 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(nuc)-1(leu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.81800079 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.31800079 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.59500122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.09500122 89.72200012 Tm [(cy)-1(t)1(oplas)1(m.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.33000183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.83000183 89.72200012 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.63700104 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.13699341 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.44400024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.94400024 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.50500488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.00500488 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.97999573 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.47999573 89.72200012 Tm [(po)1(ten)-1(t)1(ial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.07299805 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.57299805 89.72200012 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.55299377 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.05300903 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.33099365 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(rat)1(ional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.79600143 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.29600143 105.3219986 Tm [(design)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.02300262 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.52300262 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.36499786 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.86499786 105.3219986 Tm [(dr)1(u)-1(g)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.52700043 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.02700043 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.10199738 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.60199738 105.3219986 Tm [(tr)1(e)-1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.82600403 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.32600403 105.3219986 Tm [(pa)1(rasitic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.28199768 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.78199768 105.3219986 Tm [(infec)-1(t)1(i)-1(o)1(ns)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.64399719 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.14399719 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.42100525 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.92098999 105.3219986 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ce)-1(r.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.22299957 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(UP)1(RT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.26000023 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(UP)1(RT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.60600281 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 174.6000061 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(uracil)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.26000023 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.76000023 11.72200012 Tm [(ph)1(osph)1(oribos)1(y)-1(lt)1(ransferase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.96099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.46099854 11.72200012 Tm [(ho)1(molog)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.75300598 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 190.94999695 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(UP)1(P;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.89800072 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.39800072 11.72200012 Tm [(FUR1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.05199814 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 207.30003357 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 0.75 m 140.55000305 125.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 126.30000305 m 140.55000305 141.90000916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 142.65000916 m 140.55000305 158.25001526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 159.00001526 m 140.55000305 174.60002136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 175.35002136 m 140.55000305 190.95002747 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 140.55000305 191.70002747 m 140.55000305 207.30003357 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 207.30003357 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 174.97502136 m 422.42498779 174.97502136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 191.32502747 m 422.42498779 191.32502747 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 207.67503357 m 423.17498779 207.67503357 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>