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0 g [<000A000B000C000D000E>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(UHRF2)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 128.87600708 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 181.37600708 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 186.62600708 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(U)1(HRF)-1(2)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 112.86000061 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 115.23400116 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 144.0059967 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 146.38000488 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 196.70100403 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 199.07499695 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 236.8710022 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 101.32900238 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 103.70300293 12.82499981 Tm [(li)-1(ke)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 118.51999664 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 120.89399719 12.82499981 Tm [(with)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 139.84300232 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 142.21699524 12.82499981 Tm [(PHD)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 160.64300537 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 163.01699829 12.82499981 Tm [(and)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 179.08000183 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 181.45399475 12.82499981 Tm [(rin)-1(g)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 197.98300171 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 200.35699463 12.82499981 Tm [(fi)-1(nge)1(r)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 225.31500244 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 227.68899536 12.82499981 Tm [(do)-1(mains)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 264.19299316 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 266.56698608 12.82499981 Tm [(2;)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 274.69799805 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 277.07199097 12.82499981 Tm [(NI)1(RF)-1(;)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 299.83099365 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 302.20498657 12.82499981 Tm [(URF2;)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 327.59899902 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 329.97299194 12.82499981 Tm [(RN)1(F)-1(107)1(;)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 366.05099487 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 368.42498779 12.82499981 Tm [(TD)-1(RD23)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 402.80599976 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 66 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <</MCID 67 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 71 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <</MCID 72 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UHRF2)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 92.12599945 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001F002000210022000E>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 81 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0023>] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 83 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <</MCID 84 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 85 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 90 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130026000E>] TJ ET EMC /P <</MCID 91 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 96 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 97 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 98 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 187.94999695 l 0.375 187.94999695 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 99 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 100 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 139.42500305 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 139.42500305 187.94999695 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 101 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(nuc)-1(lear)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 129.18800354 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 133.68800354 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 164.99499512 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 169.49499512 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 194.59199524 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 199.09199524 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 205.65299988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 210.15299988 11.72200012 Tm [(involved)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 246.52200317 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 251.02200317 11.72200012 Tm [(in)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 258.9630127 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 263.4630127 11.72200012 Tm [(ce)-1(l)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(l-cyc)-1(le)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 27.57999992 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 32.08000183 27.3220005 Tm [(regulat)1(i)-1(o)1(n)-1(.)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 78.47699738 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 82.97699738 27.3220005 Tm [(The)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 98.78399658 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 103.28399658 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 140.79100037 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 145.29100037 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 176.5980072 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 181.0980072 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 187.65899658 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 192.15899658 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 197.13400269 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 201.63400269 27.3220005 Tm [(ubiquitin-)1(l)-1(ig)1(ase)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 269.00201416 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(capab)1(le)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 33.45999908 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 37.95999908 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 46.80199814 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 51.30199814 42.92200089 Tm [(ubiquinat)1(i)-1(ng)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 106.26000214 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 110.76000214 42.92200089 Tm [(PCNP)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 135.11000061 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 139.61000061 42.92200089 Tm [(\(PEST-conta)1(in)-1(ing)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 213.06500244 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 217.56500244 42.92200089 Tm [(nuc)-1(lear)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 249.08299255 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 253.58299255 42.92200089 Tm [(pro)1(t)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ein)-1(\),)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 18.21999931 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 22.71999931 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 38.99700165 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 43.49700165 58.52199936 Tm [(to)1(gether)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 80.87200165 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 85.37200165 58.52199936 Tm [(th)1(e)-1(y)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 104.13700104 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 108.63700104 58.52199936 Tm [(may)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 126.80799866 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 131.30799866 58.52199936 Tm [(play)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 149.18899536 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 153.68899536 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 158.66400146 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 163.16400146 58.52199936 Tm [(role)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 179.82400513 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 184.32400513 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 192.26499939 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 196.76499939 58.52199936 Tm [(tumor)1(ige)-1(nesis.)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 260.05899048 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 264.55899048 58.52199936 Tm [(Th)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 47.11299896 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 51.61299896 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 82.91999817 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 87.41999817 74.12200165 Tm [(contains)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 123.63500214 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 128.13499451 74.12200165 Tm [(an)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 138.65600586 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 143.15600586 74.12200165 Tm [(NIRF_N)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 175.12600708 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 179.62600708 74.12200165 Tm [(do)1(main,)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 214.61999512 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 219.11999512 74.12200165 Tm [(a)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 224.09500122 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 228.59500122 74.12200165 Tm [(PHD)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 247.91799927 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 252.41799927 74.12200165 Tm [(finge)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(r,)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 5.60300016 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 10.10299969 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 15.07800007 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 19.57799911 89.72200012 Tm [(set-)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 36.09700012 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 40.59700012 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 56.87400055 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 61.37400055 89.72200012 Tm [(ring-)1(associated)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 127.52899933 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 132.02900696 89.72200012 Tm [(\(SRA\))] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 155.44299316 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 159.94299316 89.72200012 Tm [(do)1(main,)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 194.93699646 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 199.43699646 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 215.71400452 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 220.21400452 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 225.18899536 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 229.68899536 89.72200012 Tm [(RING)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 252.22000122 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 256.72000122 89.72200012 Tm [(fing)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(er)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 8.54300022 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 13.04300022 105.3219986 Tm [(do)1(main)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 45.86999893 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 50.36999893 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 66.64700317 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 71.14700317 105.3219986 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 101.05599976 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 105.55599976 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 114.39800262 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 118.89800262 105.3219986 Tm [(th)1(e)-1(se)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 142.17100525 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 146.67100525 105.3219986 Tm [(do)1(mains)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 183.66400146 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 188.16400146 105.3219986 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 208.51100159 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 213.01100159 105.3219986 Tm [(been)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 234.51800537 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 239.01800537 105.3219986 Tm [(sho)1(wn)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 267.09899902 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 271.59899902 105.3219986 Tm [(t)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(o)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 5.72200012 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 10.22200012 120.92199707 Tm [(be)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 21.07600021 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 25.57600021 120.92199707 Tm [(esse)-1(nt)1(ial)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 62.7840004 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 67.28399658 120.92199707 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 79.56199646 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 84.06199646 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 98.06300354 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 102.56300354 120.92199707 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 146.79400635 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 151.29400635 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 160.13600159 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 164.63600159 120.92199707 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 179.04600525 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 183.54600525 120.92199707 Tm [(pro)1(life)-1(r)1(ation.)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 239.06199646 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 243.56199646 120.92199707 Tm [(This)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 260.82400513 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 265.32400513 120.92199707 Tm [(pr)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 22.12199974 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 26.62199974 136.52200317 Tm [(may)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 44.79299927 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 49.29299927 136.52200317 Tm [(also)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 66.55000305 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 71.05000305 136.52200317 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 91.39700317 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 95.89700317 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 100.87200165 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 105.37200165 136.52200317 Tm [(role)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 122.03199768 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 126.53199768 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 134.4730072 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 138.9730072 136.52200317 Tm [(intra)1(n)-1(ucle)-1(ar)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 190.19599915 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 194.69599915 136.52200317 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 247.47399902 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 251.97399902 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 260.81600952 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 265.31600952 136.52200317 Tm [(p)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(olygluta)1(mi)-1(ne)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 56.38600159 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 60.88600159 152.12199402 Tm [(ag)1(gregat)1(e)-1(s)1(.)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 111.44100189 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 115.94100189 152.12199402 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 162.66400146 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 167.16400146 152.12199402 Tm [(splicin)-1(g)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 200.07899475 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 204.57899475 152.12199402 Tm [(results)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 232.7480011 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 237.2480011 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 245.18899536 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 249.68899536 152.12199402 Tm [(multi)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ple)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 13.25 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 17.75 167.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 58.67200089 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 63.17200089 167.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 96.74199677 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 101.24199677 167.72200012 Tm [(some)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 124.66899872 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 129.16900635 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 138.01100159 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 142.51100159 167.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 167.60800171 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 172.10800171 167.72200012 Tm [(are)] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 185.62600708 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 190.12600708 167.72200012 Tm [(non-p)1(rotein)] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 242.13999939 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 246.63999939 167.72200012 Tm [(codin)] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(g.)] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 7.92299986 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 187.94999695 cm q 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 307 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 308 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 139.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 309 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB)] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 0.75 m 139.05000305 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 188.69999695 m 139.05000305 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 188.32499695 m 422.42498779 188.32499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 204.67500305 m 423.17498779 204.67500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
endobj
6 0 obj
<</Length1 115 0 R/Length 29432>>stream
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