%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 144 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 83.62799835 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 155.39199829 23.67700005 Tm 0 Tr [(UCHL1)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 221.23100281 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 331.67098999 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(UCHL1)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 128.36399841 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 180.86399841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.61399841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(U)1(CHL)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.34700012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.72100067 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.49299622 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.86700439 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.18800354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.56199646 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.32900238 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.0019989 12.82499981 Tm [(C-term)1(i)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.97099304 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.64399719 12.82499981 Tm [(hydrol)-1(ase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.397995 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.07099915 12.82499981 Tm [(L1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.61700439 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.28999329 12.82499981 Tm [(NDGOA)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.98901367 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.6619873 12.82499981 Tm [(PA)1(RK5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.44900513 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.12200928 12.82499981 Tm [(PG)1(P95;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 338.04800415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 344.7210083 12.82499981 Tm [(SPG79;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 375.04699707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 381.72000122 12.82499981 Tm [(PG)1(P9.5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29598999 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(Uc)1(h)-1(-L1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.45399857 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.82799911 30.49699783 Tm [(HEL)-1(-117)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.90100098 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.27500153 30.49699783 Tm [(PG)1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.7480011 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.12200165 30.49699783 Tm [(9.5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.22599792 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.59999847 30.49699783 Tm [(HEL)-1(-S-)-1(5)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.58000183 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UCHL1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.61399841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.73600006 12.82499981 Tm [(Mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.64700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 431.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 141.67500305 94.34999847 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(belongs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.54499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.04499817 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.11999512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.61999512 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.1210022 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.4750061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(C12)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.57600021 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.07600021 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.32400131 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.82400131 27.3220005 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.08599854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.58599854 27.3220005 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.96700287 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.46700287 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.02799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.52799988 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.50300598 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.00300598 27.3220005 Tm [(th)1(iol)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.40899658 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.90899658 27.3220005 Tm [(pro)1(tease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.52200317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.02200317 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.2440033 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.7440033 27.3220005 Tm [(hydro)1(ly)-1(z)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.8210144 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.9749999 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.47500038 42.92200089 Tm [(pept)1(ide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.68899918 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18899918 42.92200089 Tm [(bo)1(n)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.96099854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.46099854 42.92200089 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.78900146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.28900146 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.29000092 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.79000092 42.92200089 Tm [(C-t)1(e)-1(r)1(min)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.34399414 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.84399414 42.92200089 Tm [(glyc)-1(ine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.32000732 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.82000732 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.66200256 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.16200256 42.92200089 Tm [(ubiquitin.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.00900269 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.50900269 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.77099609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.51600075 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.01600075 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.57699966 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.07699966 58.52199936 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.56199646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.06199646 58.52199936 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.21600342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.71600342 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.65699768 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.15699768 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.15800476 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.65800476 58.52199936 Tm [(ne)-1(uro)1(n)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.72599792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.22599792 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.50300598 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.00300598 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.94400024 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.44400024 58.52199936 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.01998901 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.51998901 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.36199951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.0010004 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50099945 74.12200165 Tm [(dif)1(fuse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.71099854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.21099854 74.12200165 Tm [(ne)-1(uro)1(e)-1(ndo)1(c)-1(rine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.69499969 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.19499969 74.12200165 Tm [(system.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.3500061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.8500061 74.12200165 Tm [(Mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.69900513 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.19900513 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.13999939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.63999939 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.09599304 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.59599304 74.12200165 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.11199951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.17099953 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.67099953 89.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.52500153 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.02500153 89.72200012 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.15200043 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.65200043 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.04799652 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.54799652 89.72200012 Tm [(Par)1(k)-1(inson)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.74000549 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.24000549 89.72200012 Tm [(disease.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.07800293 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 94.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.89900017 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 110.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(UCHL1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.59700012 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(UCHL1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.94299316 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 143.3999939 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ubiquitin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.68099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.18099976 11.72200012 Tm [(C-t)1(e)-1(r)1(min)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.73500061 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.23500061 11.72200012 Tm [(hydro)1(lase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.09700012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.59700012 11.72200012 Tm [(L1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.49299622 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159.75 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 141.67500305 31.95000076 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NDG)1(OA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.69900131 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.19900131 11.72200012 Tm [(PA)1(RK5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.07099915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.57099915 11.72200012 Tm [(PG)1(P9)-1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.99900055 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.49900055 11.72200012 Tm [(SPG79;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.61500549 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.11500549 11.72200012 Tm [(PG)1(P9)-1(.)1(5)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.70899963 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.20899963 11.72200012 Tm [(Uch-)1(L)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.93899536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.43899536 11.72200012 Tm [(HEL-11)-1(7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.85998535 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.35998535 11.72200012 Tm [(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(GP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.19900036 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.6989994 27.3220005 Tm [(9.5)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.58799934 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.08800125 27.3220005 Tm [(HEL-S-53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.15299988 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 191.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 0.75 m 141.30000305 94.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 95.09999847 m 141.30000305 110.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 111.44999695 m 141.30000305 127.04999542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 127.79999542 m 141.30000305 143.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 144.1499939 m 141.30000305 159.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 160.5 m 141.30000305 191.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 191.69999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 94.72499847 m 422.42498779 94.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.07499695 m 422.42498779 111.07499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 127.42499542 m 422.42498779 127.42499542 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.7749939 m 422.42498779 143.7749939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.125 m 422.42498779 160.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 192.07499695 m 423.17498779 192.07499695 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>