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Tm [(:)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(U)1(BE2J1)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 115.30000305 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 117.6740036 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 146.44599915 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 148.82000732 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 199.14100647 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 201.51499939 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 239.31100464 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CGI-76;)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 94.53600311 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 96.91000366 12.82499981 Tm [(HS)-1(P)1(C153;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 138.07400513 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 140.44799805 12.82499981 Tm [(HS)-1(P)1(C205;)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 181.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 183.98599243 12.82499981 Tm [(HS)-1(U)1(9324)1(3;)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 231.50799561 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 233.88200378 12.82499981 Tm [(NCU)1(BE)-1(-1;)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 275.17999268 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 277.5539856 12.82499981 Tm [(NCU)1(BE)-1(1)1(;)] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 315.63699341 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 318.01098633 12.82499981 Tm [(UBC6;)] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 344.18899536 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 346.56298828 12.82499981 Tm [(UBC6E;)] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 377.86801147 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 380.24200439 12.82499981 Tm [(Ubc6p)] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 407.77398682 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC 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0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0019>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBE2J1)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 94.56700134 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 66 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001A>] TJ ET EMC /P <</MCID 67 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 74 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(,)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 101.36000061 12.82499981 Tm [(Do)-1(g)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 118.2990036 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 120.67299652 12.82499981 Tm [(,)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 123.29299927 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 125.66699982 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 139.91499329 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 142.28900146 12.82499981 Tm [(,)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 144.90899658 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 147.28300476 12.82499981 Tm [(Mon)-1(k)1(ey)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 182.06399536 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 184.43800354 12.82499981 Tm [(,)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 187.05799866 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 189.43200684 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 218.79400635 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 95 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002000210022000F>] TJ ET EMC /P <</MCID 96 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 98 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <</MCID 99 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 101 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0024>] TJ ET EMC /P <</MCID 102 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 103 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <</MCID 104 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 105 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <</MCID 106 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 111 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800220027>] TJ ET EMC /P <</MCID 112 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 118 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 119 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 120 >> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 121 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 89.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 122 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 141.67500305 172.3500061 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 123 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(mod)1(i)-1(f)1(ic)-1(at)1(ion)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 74.63200378 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 79.13200378 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 87.97399902 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 92.47399902 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 127.9469986 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 132.44700623 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 150.84300232 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 155.34300232 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 194.02400208 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 198.52400208 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 205.08500671 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 209.58500671 11.72200012 Tm [(an)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 220.10600281 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 224.60600281 11.72200012 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 267.56698608 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 30.76199913 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 35.26200104 27.3220005 Tm [(mec)-1(ha)1(n)-1(ism)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 84.3710022 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 88.8710022 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 101.14900208 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 105.64900208 27.3220005 Tm [(ta)1(rgeting)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 145.32699585 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 149.82699585 27.3220005 Tm [(ab)1(n)-1(o)1(rmal)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 191.05599976 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 195.55599976 27.3220005 Tm [(or)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 204.71400452 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 209.21400452 27.3220005 Tm [(sho)1(rt-)1(li)-1(v)1(e)-1(d)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 255.70399475 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 260.20401001 27.3220005 Tm [(pr)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ot)1(e)-1(ins)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 26.28800011 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 30.78800011 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 43.06600189 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 47.56600189 42.92200089 Tm [(degra)1(dat)1(ion.)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 102.51100159 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 107.01100159 42.92200089 Tm [(Ub)1(iquitinatio)1(n)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 168.85499573 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 173.35499573 42.92200089 Tm [(involves)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 208.13299561 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 212.63299561 42.92200089 Tm [(at)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 220.96099854 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 225.46099854 42.92200089 Tm [(least)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 245.45599365 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 249.95599365 42.92200089 Tm [(th)1(re)-1(e)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 272.5 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(cl)-1(a)1(sses)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 29.48699951 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 33.98699951 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 42.82899857 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 47.32899857 58.52199936 Tm [(en)-1(z)1(y)-1(mes:)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 87.04199982 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 91.54199982 58.52199936 Tm [(ubiquitin-)1(ac)-1(t)1(ivating)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 176.102005 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 180.602005 58.52199936 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 220.31500244 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 224.81500244 58.52199936 Tm [(or)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 233.9730072 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 238.4730072 58.52199936 Tm [(E1s,)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 255.03199768 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 259.53201294 58.52199936 Tm [(ubi)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(quitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 80.39800262 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 84.89800262 74.12200165 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 124.61100006 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 129.11099243 74.12200165 Tm [(or)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 138.26899719 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 142.76899719 74.12200165 Tm [(E2s,)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 159.32800293 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 163.82800293 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 180.10499573 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 184.60499573 74.12200165 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 258.48599243 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 262.98599243 74.12200165 Tm [(lig)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ases,)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 20.57999992 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 25.07999992 89.72200012 Tm [(or)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 34.23799896 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 38.73799896 89.72200012 Tm [(E3s.)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 55.29700089 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 59.79700089 89.72200012 Tm [(This)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 77.05899811 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 81.55899811 89.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 103.07499695 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 107.57499695 89.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 143.49200439 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 147.99200439 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 152.96699524 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 157.46699524 89.72200012 Tm [(member)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 193.73100281 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 198.23100281 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 207.07299805 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 211.57299805 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 225.57400513 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 230.07400513 89.72200012 Tm [(E2)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 240.30000305 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 244.80000305 89.72200012 Tm [(ubiqui)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(tin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 66.69999695 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 71.19999695 105.3219986 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 104.58100128 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 109.08100128 105.3219986 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 137.32899475 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 141.82899475 105.3219986 Tm [(This)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 159.09100342 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 163.59100342 105.3219986 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 196.97200012 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 201.47200012 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 208.03300476 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 212.53300476 105.3219986 Tm [(located)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 244.35400391 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 248.85400391 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 256.79501343 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 261.29501343 105.3219986 Tm [(th)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(e)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 5.10599995 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 9.60599995 120.92199707 Tm [(membrane)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 56.38999939 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 60.88999939 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 69.73200226 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 74.23200226 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 88.23300171 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 92.73300171 120.92199707 Tm [(en)-1(d)1(oplas)1(mi)-1(c)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 147.48899841 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 151.98899841 120.92199707 Tm [(reticu)-1(lum)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 192.71299744 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 197.21299744 120.92199707 Tm [(\(ER\))] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 214.04800415 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 218.54800415 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 234.82499695 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 239.32499695 120.92199707 Tm [(may)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 257.4960022 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 261.9960022 120.92199707 Tm [(co)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ntrib)1(u)-1(t)1(e)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 34.48400116 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 38.98400116 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 48.05899811 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 52.55899811 136.52200317 Tm [(qualit)1(y)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 81.74299622 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 86.24299622 136.52200317 Tm [(control)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 116.93000031 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 121.43000031 136.52200317 Tm [(ER-)1(associat)1(e)-1(d)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 181.2749939 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 185.7749939 136.52200317 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 238.55299377 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 243.05299377 136.52200317 Tm [(by)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 253.56500244 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 258.06500244 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 272.06600952 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ubiquitin-)1(prot)1(e)-1(a)1(some)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 94.34200287 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 98.84200287 152.12199402 Tm [(system.)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 130.99699402 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 135.49699402 152.12199402 Tm [([pr)1(ovided)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 177.147995 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 181.647995 152.12199402 Tm [(by)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 192.16000366 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 196.66000366 152.12199402 Tm [(RefSeq].)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 231.99200439 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 236.49200439 152.12199402 Tm [(COMPLE)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(TENESS:)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 34.9280014 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 39.4280014 167.72200012 Tm [(complete)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 79.80500031 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 84.30500031 167.72200012 Tm [(on)] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 95.57299805 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 100.07299805 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 114.0739975 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 118.5739975 167.72200012 Tm [(3')] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 126.15899658 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 130.65899658 167.72200012 Tm [(en)-1(d)1(.)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 149.23500061 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 172.3500061 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 298 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 299 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 300 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC,)] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 39.26499939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 43.76499939 11.72200012 Tm [(FC)] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 54.56700134 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 188.69999695 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 306 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 311 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 312 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(UBE2J1)] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 31.43400002 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 205.05001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 0.75 m 141.30000305 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 173.1000061 m 141.30000305 188.70001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 189.45001221 m 141.30000305 205.05001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 205.05001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 172.7250061 m 422.42498779 172.7250061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 189.07501221 m 422.42498779 189.07501221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 205.42501831 m 423.17498779 205.42501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
endobj
6 0 obj
<</Length1 127 0 R/Length 31468>>stream
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