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Tm [(:)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(U)1(BE2E)-1(3)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 117.07900238 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 119.45300293 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 148.2250061 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 150.59899902 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 200.91999817 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 203.29400635 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 241.08999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<000C>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(UBCH9;)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 74.72000122 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 77.09400177 12.82499981 Tm [(UbcM2)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 108.08599854 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 37 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0011>] TJ ET EMC /P <</MCID 38 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [<001200130014>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.35800171 12.82499981 Tm [<00150016>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 113.60800171 12.82499981 Tm [<00170018>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0019>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(UBE2E3)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 75.34600067 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001A>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<001B>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 71.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002000210022000F>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 74 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0024>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 81 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 88 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800220027>] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 96 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 97 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 98 >> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 187.94999695 l 0.375 187.94999695 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 99 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 97.52200317 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 100 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 138.67500305 187.94999695 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 101 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(mod)1(i)-1(f)1(ic)-1(at)1(ion)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 74.63200378 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 79.13200378 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 87.97399902 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 92.47399902 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 127.9469986 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 132.44700623 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 150.84300232 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 155.34300232 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 194.02400208 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 198.52400208 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 205.08500671 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 209.58500671 11.72200012 Tm [(an)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 220.10600281 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 224.60600281 11.72200012 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 267.56698608 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 272.06698608 11.72200012 Tm [(c)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ell)-1(ular)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 26.24900055 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 30.74900055 27.3220005 Tm [(mec)-1(ha)1(n)-1(ism)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 79.85800171 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 84.35800171 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 96.63600159 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 101.13600159 27.3220005 Tm [(ta)1(rgeting)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 140.81399536 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 145.31399536 27.3220005 Tm [(ab)1(n)-1(o)1(rmal)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 186.54299927 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 191.04299927 27.3220005 Tm [(or)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 200.20100403 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 204.70100403 27.3220005 Tm [(sho)1(rt-)1(li)-1(v)1(e)-1(d)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 251.19099426 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 255.69099426 27.3220005 Tm [(pro)1(t)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ein)-1(s)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 17.21299934 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 21.71299934 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 33.99100113 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 38.49100113 42.92200089 Tm [(degra)1(dat)1(ion.)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 93.43599701 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 97.93599701 42.92200089 Tm [(Ub)1(iquitinatio)1(n)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 159.77999878 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 164.27999878 42.92200089 Tm [(involves)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 199.05799866 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 203.55799866 42.92200089 Tm [(at)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 211.88600159 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 216.38600159 42.92200089 Tm [(least)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 236.3809967 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 240.8809967 42.92200089 Tm [(th)1(ree)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 263.42498779 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 267.92498779 42.92200089 Tm [(cl)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(asses)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 22.57900047 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 27.07900047 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 35.92100143 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 40.42100143 58.52199936 Tm [(en)-1(z)1(y)-1(mes:)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 80.13400269 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 84.63400269 58.52199936 Tm [(ubiquitin-)1(ac)-1(t)1(ivating)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 169.19400024 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 173.69400024 58.52199936 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 213.40699768 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 217.90699768 58.52199936 Tm [(or)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 227.06500244 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 231.56500244 58.52199936 Tm [(E1s,)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 248.12399292 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 252.62399292 58.52199936 Tm [(ubiq)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(uitin-conju)-1(g)1(at)1(i)-1(ng)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 74.64099884 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 79.14099884 74.12200165 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 118.85399628 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 123.35399628 74.12200165 Tm [(or)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 132.51199341 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 137.01199341 74.12200165 Tm [(E2s,)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 153.57099915 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 158.07099915 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 174.3480072 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 178.8480072 74.12200165 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 252.72900391 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 257.22900391 74.12200165 Tm [(ligas)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(es,)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 11.43900013 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 15.93900013 89.72200012 Tm [(or)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 25.09700012 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 29.59700012 89.72200012 Tm [(E3s.)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 46.15599823 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 50.65599823 89.72200012 Tm [(This)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 67.91799927 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 72.41799927 89.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 93.93399811 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 98.43399811 89.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 134.35099792 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 138.85099792 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 143.82600403 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 148.32600403 89.72200012 Tm [(member)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 184.58999634 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 189.08999634 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 197.93200684 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 202.43200684 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 216.43299866 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 220.93299866 89.72200012 Tm [(E2)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 231.15899658 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 235.65899658 89.72200012 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(-conjugat)1(in)-1(g)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 55.40599823 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 59.90599823 105.3219986 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 93.28700256 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 97.78700256 105.3219986 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 126.03500366 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 130.53500366 105.3219986 Tm [(The)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 146.34199524 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 150.84199524 105.3219986 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 188.34899902 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 192.84899902 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 224.15600586 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 228.65600586 105.3219986 Tm [(sha)1(re)-1(s)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 256.04699707 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 260.54699707 105.3219986 Tm [(10)-1(0)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(%)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 8.00699997 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 12.50699997 120.92199707 Tm [(seque)-1(nce)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 53.35400009 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 57.85400009 120.92199707 Tm [(identity)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 90.52300262 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 95.02300262 120.92199707 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 113.41899872 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 117.91899872 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 131.91999817 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 136.41999817 120.92199707 Tm [(mouse)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 165.39300537 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 169.89300537 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 186.16999817 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 190.66999817 120.92199707 Tm [(rat)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 202.43400574 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 206.93400574 120.92199707 Tm [(coun)-1(t)1(e)-1(r)1(part)1(s,)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 264.00100708 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 268.50100708 120.92199707 Tm [(w)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(hich)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 17.99099922 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 22.49099922 136.52200317 Tm [(indic)-1(a)1(tes)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 60.6969986 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 65.1969986 136.52200317 Tm [(th)1(at)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 82.41899872 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 86.91899872 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 102.375 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 106.875 136.52200317 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 140.2559967 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 144.7559967 136.52200317 Tm [(is)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 151.31700134 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 155.81700134 136.52200317 Tm [(hig)1(hly)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 182.21099854 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 186.71099854 136.52200317 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 230.78799438 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 235.28799438 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 243.22900391 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 247.72900391 136.52200317 Tm [(eu)-1(kary)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ot)1(e)-1(s.)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 20.51399994 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 25.01399994 152.12199402 Tm [(Two)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 43.00099945 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 47.50099945 152.12199402 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 100.02400208 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 104.52400208 152.12199402 Tm [(splice)-1(d)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 134.60499573 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 139.10499573 152.12199402 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 180.0269928 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 184.5269928 152.12199402 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 218.09700012 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 222.59700012 152.12199402 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 262.93899536 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 267.43899536 152.12199402 Tm [(th)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(e)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 5.10599995 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 9.60599995 167.72200012 Tm [(same)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 32.2859993 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 36.7859993 167.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 68.09300232 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 72.59300232 167.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 92.94000244 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 97.44000244 167.72200012 Tm [(been)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 118.9469986 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 123.4469986 167.72200012 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 149.13699341 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 153.63699341 167.72200012 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 165.91499329 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 170.41499329 167.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 185.8710022 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 190.3710022 167.72200012 Tm [(gene)-1(.)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 214.05299377 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 218.55299377 167.72200012 Tm [([pr)1(ovided)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 260.20401001 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 264.70401001 167.72200012 Tm [(by)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 275.21600342 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(RefSeq].)] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 35.33200073 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 187.94999695 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 295 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 296 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 138.67500305 16.35000038 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 297 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC,)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 39.26499939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 43.76499939 11.72200012 Tm [(IF,)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 53.35800171 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 57.85800171 11.72200012 Tm [(FC)] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 68.66000366 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 0.75 m 138.30000305 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 188.69999695 m 138.30000305 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 188.32499695 m 422.42498779 188.32499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 204.67500305 m 423.17498779 204.67500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
endobj
6 0 obj
<</Length1 127 0 R/Length 26472>>stream
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