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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 66 0 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(UB)1(A7)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 128.44000244 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 238.88000488 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(UBA)1(7)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 113.09500122 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 165.59500122 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 170.84500122 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(U)1(BA7)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 107.57900238 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 109.95300293 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 138.7250061 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 141.09899902 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 191.41999817 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 193.79400635 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 231.58999634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000C000E>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ub)-1(iq)-1(ui)-1(tin)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 101.32900238 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 103.70300293 12.82499981 Tm [(li)-1(ke)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 118.51999664 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 120.89399719 12.82499981 Tm [(mod)-1(ifi)-1(e)1(r)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 157.2440033 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 159.61799622 12.82499981 Tm [(activatin)-1(g)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 201.17199707 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 203.54600525 12.82499981 Tm [(enzym)1(e)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 236.79899597 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 239.17300415 12.82499981 Tm [(7;)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 247.30400085 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 249.67799377 12.82499981 Tm [(D8;)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 264.26901245 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 266.64300537 12.82499981 Tm [(UBE2;)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 292.3500061 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 294.72399902 12.82499981 Tm [(UBA)1(1B;)] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 327.08999634 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 329.46398926 12.82499981 Tm [(UBE1L)] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 356.7749939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000E>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000E>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 66 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000E>] TJ ET EMC /P <</MCID 67 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(UBA)1(7)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 86.84500122 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001F002000210022000E>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 74 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002300240025000E>] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130026000E>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 85 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 86 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 87 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 187.94999695 l 0.375 187.94999695 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 88 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 142.42500305 187.94999695 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(mod)1(i)-1(f)1(ic)-1(at)1(ion)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 74.63200378 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 79.13200378 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 87.97399902 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 92.47399902 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 127.9469986 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 132.44700623 11.72200012 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 150.84300232 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 155.34300232 11.72200012 Tm [(ubiquitin)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 194.02400208 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 198.52400208 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 205.08500671 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 209.58500671 11.72200012 Tm [(an)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 220.10600281 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 224.60600281 11.72200012 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 267.56698608 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 30.76199913 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 35.26200104 27.3220005 Tm [(mec)-1(ha)1(n)-1(ism)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 84.3710022 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 88.8710022 27.3220005 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 101.14900208 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 105.64900208 27.3220005 Tm [(ta)1(rgeting)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 145.32699585 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 149.82699585 27.3220005 Tm [(ab)1(n)-1(o)1(rmal)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 191.05599976 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 195.55599976 27.3220005 Tm [(or)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 204.71400452 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 209.21400452 27.3220005 Tm [(sho)1(rt-)1(li)-1(v)1(e)-1(d)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 255.70399475 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 260.20401001 27.3220005 Tm [(pr)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ot)1(e)-1(ins)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 26.28800011 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 30.78800011 42.92200089 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 43.06600189 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 47.56600189 42.92200089 Tm [(degra)1(dat)1(ion.)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 102.51100159 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 107.01100159 42.92200089 Tm [(Ub)1(iquitinatio)1(n)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 168.85499573 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 173.35499573 42.92200089 Tm [(involves)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 208.13299561 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 212.63299561 42.92200089 Tm [(at)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 220.96099854 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 225.46099854 42.92200089 Tm [(least)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 245.45599365 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 249.95599365 42.92200089 Tm [(th)1(re)-1(e)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 272.5 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(cl)-1(a)1(sses)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 29.48699951 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 33.98699951 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 42.82899857 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 47.32899857 58.52199936 Tm [(en)-1(z)1(y)-1(mes:)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 87.04199982 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 91.54199982 58.52199936 Tm [(ubiquitin-)1(ac)-1(t)1(ivating)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 176.102005 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 180.602005 58.52199936 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 220.31500244 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 224.81500244 58.52199936 Tm [(or)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 233.9730072 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 238.4730072 58.52199936 Tm [(E1s,)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 255.03199768 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 259.53201294 58.52199936 Tm [(ubi)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(quitin-)1(c)-1(onjugat)1(ing)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 80.39800262 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 84.89800262 74.12200165 Tm [(en)-1(z)1(y)-1(mes,)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 124.61100006 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 129.11099243 74.12200165 Tm [(or)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 138.26899719 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 142.76899719 74.12200165 Tm [(E2s,)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 159.32800293 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 163.82800293 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 180.10499573 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 184.60499573 74.12200165 Tm [(ubiquitin-)1(prot)1(e)-1(in)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 258.48599243 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 262.98599243 74.12200165 Tm [(li)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ga)1(se)-1(s,)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 26.33600044 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 30.83600044 89.72200012 Tm [(or)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 39.99399948 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 44.49399948 89.72200012 Tm [(E3s.)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 61.0530014 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 65.5530014 89.72200012 Tm [(This)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 82.81500244 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 87.31500244 89.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 108.83100128 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 113.33100128 89.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 149.2480011 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 153.7480011 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 158.7230072 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 163.2230072 89.72200012 Tm [(member)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 199.48699951 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 203.98699951 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 212.82899475 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 217.32899475 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 231.33000183 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 235.83000183 89.72200012 Tm [(E1)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 246.05599976 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 250.55599976 89.72200012 Tm [(ubiq)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(uitin-activa)1(ting)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 65.11399841 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 69.61399841 105.3219986 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 102.99500275 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 107.49500275 105.3219986 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 135.74299622 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 140.24299622 105.3219986 Tm [(The)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 156.05000305 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 160.55000305 105.3219986 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 198.05700684 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 202.55700684 105.3219986 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 235.93800354 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 240.43800354 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 246.99899292 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 251.49899292 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 256.47399902 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 260.97399902 105.3219986 Tm [(ret)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(inoid)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 21.81399918 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 26.31399918 120.92199707 Tm [(ta)1(rget)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 52.29399872 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 56.79399872 120.92199707 Tm [(th)1(at)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 74.01599884 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 78.51599884 120.92199707 Tm [(tr)1(i)-1(g)1(gers)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 111.92299652 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 116.42299652 120.92199707 Tm [(pro)1(my)-1(elocy)-1(t)1(ic)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 177.28700256 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 181.78700256 120.92199707 Tm [(leu)-1(ke)-1(mia)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 220.64300537 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 225.14300537 120.92199707 Tm [(\(PML\)/reti)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(noic)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 18.1760006 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 22.6760006 136.52200317 Tm [(acid)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 40.31600189 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 44.81600189 136.52200317 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 81.23799896 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 85.73799896 136.52200317 Tm [(alph)1(a)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 109.37200165 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 113.87200165 136.52200317 Tm [(\(RA)1(Ralpha)1(\))] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 161.60099792 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 166.10099792 136.52200317 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 218.8789978 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 223.3789978 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 239.65600586 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 244.15600586 136.52200317 Tm [(ap)1(opt)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(osis)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 16.4489994 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 20.9489994 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 28.88999939 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 33.38999939 152.12199402 Tm [(acute)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 56.88299942 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 61.38299942 152.12199402 Tm [(pro)1(my)-1(elocy)-1(t)1(ic)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 122.24700165 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 126.74700165 152.12199402 Tm [(leu)-1(ke)-1(mia)1(,)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 167.77000427 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 172.27000427 152.12199402 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 198.56700134 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 203.06700134 152.12199402 Tm [(it)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 208.81500244 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 213.31500244 152.12199402 Tm [(is)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 219.87600708 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 224.37600708 152.12199402 Tm [(involved)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 260.74499512 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 265.24499512 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 273.18600464 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 14.0010004 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 18.50099945 167.72200012 Tm [(conj)-1(ug)1(ation)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 69.97899628 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 74.47899628 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 83.32099915 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 87.82099915 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 101.8219986 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 106.3219986 167.72200012 Tm [(ubiquitin-)1(l)-1(ike)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 163.69299316 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 168.19299316 167.72200012 Tm [(interferon-s)1(timulated)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 260.33300781 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 264.83300781 167.72200012 Tm [(g)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(en)-1(e)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 15.75899982 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 20.25900078 183.32200623 Tm [(15)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 30.81500053 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 35.31499863 183.32200623 Tm [(pro)1(tein)-1(.)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 68.78800201 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 187.94999695 cm q 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 274 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 275 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 276 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 0.75 m 142.05000305 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 188.69999695 m 142.05000305 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 188.32499695 m 422.42498779 188.32499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 204.67500305 m 423.17498779 204.67500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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