%PDF-1.5
%ÈÈÈÈÈÈ?1 0 obj
<>
endobj
2 0 obj
<>/Metadata 136 0 R>>
endobj
3 0 obj
<>
endobj
4 0 obj
<>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>>
endobj
5 0 obj
<>stream
1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 66 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(TXNDC5)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 151.42799377 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 261.86801147 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 305.86801147 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.11801147 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.68499756 12.82499981 Tm [(TXNDC5)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 132.03500366 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 184.53500366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.78500366 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TXN)1(D)-1(C5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.45800018 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.83200073 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.60400391 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.97799683 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.29899597 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.67300415 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.46899414 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(HCC2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.8710022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.24500275 12.82499981 Tm [(ERP46;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.9509964 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.32499695 12.82499981 Tm [(HCC-)-1(2)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.41000366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.78399658 12.82499981 Tm [(ST)-1(RF8;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.38200378 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.7559967 12.82499981 Tm [(PDIA)1(15;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.81399536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.18800354 12.82499981 Tm [(UN)1(Q364)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.54199219 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.91598511 12.82499981 Tm [(ENDOPDI)] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.76300049 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TXNDC5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.72499847 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.36000061 12.82499981 Tm [(Mon)-1(k)1(ey)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.14100647 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002000210022000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800220027>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 50.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 94.34999847 l 142.42500305 94.34999847 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)-1(-)1(disulfide)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.50700378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.00700378 11.72200012 Tm [(isomerase.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.67900085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.17900085 11.72200012 Tm [(Its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.34399414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.84399414 11.72200012 Tm [(express)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.66300011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.16300011 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.72400093 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.22400093 27.3220005 Tm [(induc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.84400177 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.34400177 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.85600281 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.35600281 27.3220005 Tm [(hypo)1(xia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.06199646 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.56199646 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.83900452 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.33900452 27.3220005 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.25300598 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.75300598 27.3220005 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.41299438 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.91299438 27.3220005 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.08399963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.58399963 27.3220005 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.43800354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.93800354 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.01300049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.51300049 27.3220005 Tm [(pro)1(tec)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.74499512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.24499512 27.3220005 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ypoxic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.70299911 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.20299911 42.92200089 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.77899933 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.27899933 42.92200089 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.98999786 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.48999786 42.92200089 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.65100098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.15100098 42.92200089 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.87399292 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.37399292 42.92200089 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.28900146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.78900146 42.92200089 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.95799255 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.45799255 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.39898682 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.89898682 42.92200089 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ultiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.93799973 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.43799973 58.52199936 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.36000061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.86000061 58.52199936 Tm [(var)1(i)-1(a)1(n)-1(t)1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.59600067 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.09600067 58.52199936 Tm [(Read-)1(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.6000061 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.1000061 58.52199936 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.68400574 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.18400574 58.52199936 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.44100952 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.94100952 58.52199936 Tm [(ex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ists)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.07999992 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.57999992 74.12200165 Tm [(betw)1(e)-1(en)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.65200043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.15200043 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.60800171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.10800171 74.12200165 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.62400055 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.12400055 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.40100098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.90100098 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.9019928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.4019928 74.12200165 Tm [(ne)-1(ig)1(hbo)1(rin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.352005 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.852005 74.12200165 Tm [(upst)1(re)-1(a)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.61599731 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.11599731 74.12200165 Tm [(MUT)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ED)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.8039999 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.30400085 89.72200012 Tm [(\(muted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.50500107 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.00500107 89.72200012 Tm [(ho)1(molog\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.30200195 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.80200195 89.72200012 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.48400116 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.98400116 89.72200012 Tm [([pr)1(ovided)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.63499451 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.13499451 89.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.64700317 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.14700317 89.72200012 Tm [(RefSeq,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.4730072 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.9730072 89.72200012 Tm [(Dec)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.44799805 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.94799805 89.72200012 Tm [(20)-1(10)-1(].)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.23199463 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 94.34999847 cm q 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 110.69999695 cm q 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(TXNDC5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.43500137 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.05000305 cm q 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(TXNDC5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.78100586 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 143.3999939 cm q 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 19.52199936 Tm 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 19.52199936 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 48.35800171 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 142.42500305 31.95000076 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(th)1(ioredoxin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.53499985 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.03499985 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.86199951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.36199951 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.10899353 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.60899353 11.72200012 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.88699341 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.38699341 11.72200012 Tm [(\(TXNDC5\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.5 11.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.42199707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.92199707 11.72200012 Tm [(var)1(i)-1(a)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.35299993 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.85300016 27.3220005 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.13099957 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 175.3500061 cm q 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(HCC2)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.44599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.94599915 11.72200012 Tm [(ERP)1(4)-1(6;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.9980011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.4980011 11.72200012 Tm [(HCC-2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.83799744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.33799744 11.72200012 Tm [(STRF8)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.79299927 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.29299927 11.72200012 Tm [(PDI)1(A1)-1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.35499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.85499573 11.72200012 Tm [(UNQ364)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.22599792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.72599792 11.72200012 Tm [(ENDO)1(PDI)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.18798828 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 191.69999695 cm q 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 142.42500305 16.35000038 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Q8NB)-1(S9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.04800034 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.05000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 0.75 m 142.05000305 94.34999847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 95.09999847 m 142.05000305 110.69999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 111.44999695 m 142.05000305 127.04999542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 127.79999542 m 142.05000305 143.3999939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 144.1499939 m 142.05000305 175.34999084 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 176.09999084 m 142.05000305 191.69999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 192.44999695 m 142.05000305 208.05000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 208.05000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 94.72499847 m 422.42498779 94.72499847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.07499695 m 422.42498779 111.07499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 127.42499542 m 422.42498779 127.42499542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.7749939 m 422.42498779 143.7749939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 175.72499084 m 422.42498779 175.72499084 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 192.07499695 m 422.42498779 192.07499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 208.42500305 m 423.17498779 208.42500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
endstream
endobj
6 0 obj
<>stream
ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>