%PDF-1.5
%ÈÈÈÈÈÈ?1 0 obj
<>
endobj
2 0 obj
<>/Metadata 136 0 R>>
endobj
3 0 obj
<>
endobj
4 0 obj
<>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>>
endobj
5 0 obj
<>stream
1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 88 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(TUB)1(B2B)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 150.66499329 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 261.10501099 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.10501099 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.68499756 12.82499981 Tm [(TUBB2B)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 131.61999512 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 184.11999512 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.36999512 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TUB)1(B2B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.04299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.41699982 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.18899536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.56300354 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.88400269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.25799561 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.05400085 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(bA506K)1(6.1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.11599731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.48999786 12.82499981 Tm [(PMG)1(Y)-1(SA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.53199768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TUBB2B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.30999756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002000210022000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800220027>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 42.92200089 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 78.75 l 141.67500305 78.75 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82299805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.32299805 11.72200012 Tm [(isof)1(orm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.31700134 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.81700134 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.65899658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.15899658 11.72200012 Tm [(tub)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ulin)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.04800034 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.54800034 27.3220005 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.64500046 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.14500046 27.3220005 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.75700378 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.25700378 27.3220005 Tm [(GTP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.61499786 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.11499786 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.39199829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.89199829 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.45300293 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.95300293 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.92799377 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.42799377 27.3220005 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.397995 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.897995 27.3220005 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.58700562 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.08700562 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.92900085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.42900085 27.3220005 Tm [(mic)-1(r)1(otu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(bules.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.12800026 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.62800026 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.88999939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.38999939 42.92200089 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.90599823 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.40599823 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.96700287 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.46700287 42.92200089 Tm [(hig)1(hly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.86100006 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.36100006 42.92200089 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.55599976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.05599976 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.1309967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.6309967 42.92200089 Tm [(TUBB)-1(2A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.41400146 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.91400146 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.19099426 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.69099426 42.92200089 Tm [(TUBB)-1(2C.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.32800293 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.82800293 42.92200089 Tm [(D)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(efec)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.36499977 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.86499977 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.80599976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.30599976 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.76200104 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.26200104 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.77799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.27799988 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.79599762 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.29599762 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.27100372 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.77100372 58.52199936 Tm [(cause)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.07699585 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.57699585 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.41900635 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.91900635 58.52199936 Tm [(asymmetric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.4940033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.9940033 58.52199936 Tm [(po)1(l)-1(ymicrogyri)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(a.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.14099979 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 78.75 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.26499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.76499939 11.72200012 Tm [(IF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.19200134 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.09999847 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(TUBB)-1(2B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.09700012 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 111.44999695 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(TUBB)-1(2B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.44299316 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.80000305 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(tub)1(u)-1(lin,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.19499969 11.72200012 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.3769989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.8769989 11.72200012 Tm [(2B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.80200195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.30200195 11.72200012 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.51699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.01699829 11.72200012 Tm [(IIb)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.05599976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.55599976 11.72200012 Tm [(\(TUBB)-1(2B)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.66499329 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.1499939 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(bA)1(5)-1(06)-1(K)1(6)-1(.)1(1)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.51599884 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.01599884 11.72200012 Tm [(PMGY)1(SA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.96700287 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 160.5 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Q9B)-1(VA1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.95600128 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 176.8500061 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 19.52199936 Tm 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.47100067 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.97100067 19.52199936 Tm [(positive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.80799866 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.30799866 19.52199936 Tm [(control:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 96.39399719 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 141.67500305 31.95000076 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ad)1(e)-1(nocarcin)-1(o)1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.61299896 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.11299896 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.95500183 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.45500183 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.4960022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.9960022 11.72200012 Tm [(ova)1(ry)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.61700439 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.11700439 11.72200012 Tm [(tiss)1(u)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.84899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.34899902 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.62600708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.12600708 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.16700745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.66700745 11.72200012 Tm [(ki)-1(d)1(ne)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.13500977 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.63500977 11.72200012 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(issue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.37899971 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.80000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 0.75 m 141.30000305 78.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 79.5 m 141.30000305 95.09999847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 95.84999847 m 141.30000305 111.44999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 112.19999695 m 141.30000305 127.79999542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 128.54998779 m 141.30000305 144.1499939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 144.8999939 m 141.30000305 160.5 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 161.25 m 141.30000305 176.8500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 177.6000061 m 141.30000305 208.80000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 208.80000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.125 m 422.42498779 79.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 95.47499847 m 422.42498779 95.47499847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.82499695 m 422.42498779 111.82499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.17498779 m 422.42498779 128.17498779 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 144.5249939 m 422.42498779 144.5249939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.875 m 422.42498779 160.875 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 177.2250061 m 422.42498779 177.2250061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17500305 m 423.17498779 209.17500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
endstream
endobj
6 0 obj
<>stream
ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Ö©Öë´Ê>|
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>
<Îı¾Á´>