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Tm [(:)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TUB)1(B1)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 112.33200073 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 114.70600128 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 143.47799683 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 145.852005 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 22 >> BDC BT 1 0 0 -1 196.17300415 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 198.54699707 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 236.34300232 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 25 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC 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275.63101196 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 278.00500488 12.82499981 Tm [(1,)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 285.94699097 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 288.3210144 12.82499981 Tm [(class)] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 308.41400146 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 310.78799438 12.82499981 Tm [(VI;)] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 322.20098877 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 324.57501221 12.82499981 Tm [(tub)-1(ul)-1(in)-1(,)] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 357.59799194 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 359.97198486 12.82499981 Tm [(beta)] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 379.26000977 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 381.63400269 12.82499981 Tm [(1)] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 386.95599365 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TUBB1)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 91.59799957 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0012>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 66 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <</MCID 67 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 68 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001A>] TJ ET EMC /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 76 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 77 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 96.36599731 12.82499981 Tm [(,)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 101.36000061 12.82499981 Tm [(Do)-1(g)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 118.2990036 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 120.67299652 12.82499981 Tm [(,)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 123.29299927 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 125.66699982 12.82499981 Tm [(Rat)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 139.91499329 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 142.28900146 12.82499981 Tm [(,)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 144.90899658 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 147.28300476 12.82499981 Tm [(Mon)-1(k)1(ey)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 182.06399536 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 184.43800354 12.82499981 Tm [(,)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 187.05799866 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 189.43200684 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 218.79400635 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 97 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002000210022000F>] TJ ET EMC /P <</MCID 98 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 100 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <</MCID 101 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 103 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0024>] TJ ET EMC /P <</MCID 104 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 105 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <</MCID 106 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 107 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <</MCID 108 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 113 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800220027>] TJ ET EMC /P <</MCID 114 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 120 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 121 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 122 >> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 123 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 74.12200165 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 124 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 140.92500305 141.1499939 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 125 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(beta)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 189.45899963 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 193.95899963 11.72200012 Tm [(tub)1(u)-1(lin)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 224.48800659 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 228.98800659 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 260.29501343 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 264.79501343 11.72200012 Tm [(fa)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(mily)-1(.)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 20.15299988 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 24.65299988 27.3220005 Tm [(Be)-1(t)1(a)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 43.73400116 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 48.23400116 27.3220005 Tm [(tub)1(u)-1(lins)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 82.92900085 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 87.42900085 27.3220005 Tm [(are)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 100.9469986 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 105.4469986 27.3220005 Tm [(one)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 121.82099915 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 126.32099915 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 135.16299438 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 139.66299438 27.3220005 Tm [(tw)1(o)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 155.84399414 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 160.34399414 27.3220005 Tm [(core)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 179.12199402 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 183.62199402 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 214.92900085 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 219.42900085 27.3220005 Tm [(fa)1(mi)-1(lies)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 252.41400146 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 256.91400146 27.3220005 Tm [(\(alp)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ha)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 10.51599979 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 15.01599979 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 31.29299927 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 35.79299927 42.92200089 Tm [(beta)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 54.97499847 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 59.47499847 42.92200089 Tm [(tub)1(u)-1(lins\))] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 97.1760025 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 101.6760025 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 118.89800262 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 123.39800262 42.92200089 Tm [(heterod)1(ime)-1(riz)1(e)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 188.71800232 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 193.21800232 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 209.49499512 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 213.99499512 42.92200089 Tm [(assemble)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 254.09100342 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 258.59100342 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 267.66598511 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(fo)1(rm)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 20.71100044 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 25.21100044 58.52199936 Tm [(mic)-1(r)1(otubules.)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 83.73699951 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 88.23699951 58.52199936 Tm [(This)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 105.49900055 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 109.99900055 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 141.30599976 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 145.80599976 58.52199936 Tm [(is)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 152.36700439 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 156.86700439 58.52199936 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 203.352005 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 207.852005 58.52199936 Tm [(expressed)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 251.0059967 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 255.5059967 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 263.44699097 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 267.94699097 58.52199936 Tm [(p)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(lat)1(e)-1(lets)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 30.85000038 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 35.34999847 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 51.6269989 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 56.1269989 74.12200165 Tm [(megakaryocy)-1(t)1(e)-1(s)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 126.09700012 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 130.59700012 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 146.87399292 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 151.37399292 74.12200165 Tm [(may)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 169.54499817 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 174.04499817 74.12200165 Tm [(be)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 184.89900208 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 189.39900208 74.12200165 Tm [(involved)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 225.76800537 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 230.26800537 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 238.20899963 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 242.70899963 74.12200165 Tm [(pro)1(plat)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ele)-1(t)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 15.96100044 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 20.46100044 89.72200012 Tm [(pro)1(duc)-1(t)1(ion)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 68.1989975 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 72.6989975 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 88.97599792 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 93.47599792 89.72200012 Tm [(plat)1(el)-1(et)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 125.90799713 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 130.40800476 89.72200012 Tm [(rele)-1(a)1(se)-1(.)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 162.86599731 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 167.36599731 89.72200012 Tm [(A)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 173.69900513 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 178.19900513 89.72200012 Tm [(mutat)1(ions)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 221.68699646 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 226.18699646 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 234.12800598 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 238.62800598 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 254.08399963 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 258.58401489 89.72200012 Tm [(ge)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ne)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 10.65200043 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 15.15200043 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 21.71299934 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 26.21299934 105.3219986 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 71.33999634 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 75.83999634 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 94.23600006 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 98.73600006 105.3219986 Tm [(auto)1(somal)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 144.02200317 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 148.52200317 105.3219986 Tm [(do)1(mi)-1(na)1(n)-1(t)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 190.2480011 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 194.7480011 105.3219986 Tm [(macrot)1(hromb)1(oc)-1(yt)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(op)1(e)-1(nia.)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 31.65800095 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 36.15800095 120.92199707 Tm [(Two)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 54.14500046 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 58.64500046 120.92199707 Tm [(pseudog)1(e)-1(nes)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 116.37200165 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 120.87200165 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 129.71400452 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 134.21400452 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 149.66999817 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 154.16999817 120.92199707 Tm [(gene)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 175.68600464 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 180.18600464 120.92199707 Tm [(are)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 193.70399475 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 198.20399475 120.92199707 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 223.89399719 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 228.39399719 120.92199707 Tm [(on)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 239.66200256 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 244.16200256 120.92199707 Tm [(chrom)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(oso)1(me)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 29.14900017 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 33.64899826 136.52200317 Tm [(Y.)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 41.24700165 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 274 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 275 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 276 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC,)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 39.26499939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 43.76499939 11.72200012 Tm [(IF)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 51.19200134 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 157.5 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 282 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 287 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 288 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(TUBB)-1(1)] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 28.45000076 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 173.8500061 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 290 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <</MCID 291 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 292 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(TUBB)-1(1)] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 144.79600525 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 190.19999695 cm q 1 g 0.375 0.75 m 140.17500305 0.75 l 140.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.17500305 -0.25 l 141.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 302 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 305 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.92500305 16.35000038 l h f* Q q 1 0 0 1 140.55000305 0 cm -0.625 -0.25 m 282.875 -0.25 l 282.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 306 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(tub)1(u)-1(lin,)] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 32.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 37.19499969 11.72200012 Tm [(beta)] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 56.3769989 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 60.8769989 11.72200012 Tm [(1)] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 66.15499878 11.72200012 Tm [( )] TJ ET EMC /P 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190.95001221 m 140.55000305 206.55001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 206.55001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.875 m 422.42498779 157.875 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 174.2250061 m 422.42498779 174.2250061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 190.57501221 m 422.42498779 190.57501221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 206.92501831 m 423.17498779 206.92501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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