%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 150 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 76.59799957 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 148.36199951 23.67700005 Tm 0 Tr [(TUB)1(A1B)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 228.26199341 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 338.70199585 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TUBA)1(1B)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.42399597 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 186.92399597 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.67399597 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TUB)1(A1B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.40699768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.78099823 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.55299377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.92700195 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.2480011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.62199402 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.41799927 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tub)-1(ul)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.40299988 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.77700043 12.82499981 Tm [(alp)-1(ha)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.27899933 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.65299988 12.82499981 Tm [(1b;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.30099487 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.67500305 12.82499981 Tm [(K-A)1(L)-1(P)1(HA-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.41299438 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TUBA)1(1B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.6740036 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 35.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 63.15000153 l 141.67500305 63.15000153 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tubuli)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.33499908 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.83499908 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.39599991 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.89599991 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.89699936 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.39700317 11.72200012 Tm [(major)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.36699677 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.86699677 11.72200012 Tm [(constituent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46600342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.96600342 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.80799866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.30799866 11.72200012 Tm [(mic)-1(r)1(otubules.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.83399963 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.33399963 11.72200012 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.33299255 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.83299255 11.72200012 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.44500732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.94500732 11.72200012 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(wo)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.82800007 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.32799911 27.3220005 Tm [(moles)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.15000153 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.65000153 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.49200058 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.99200058 27.3220005 Tm [(GTP,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.51699829 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.01699829 27.3220005 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.39099884 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.89099884 27.3220005 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.21900177 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.71900177 27.3220005 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.24000549 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.74000549 27.3220005 Tm [(exc)-1(h)1(angeable)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.07099915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.57099915 27.3220005 Tm [(site)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.59199524 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.09199524 27.3220005 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.36000061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.86000061 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.86099243 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.36099243 27.3220005 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.54299927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(chain)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.96999931 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.46999931 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.74700165 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.24700165 42.92200089 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.6210022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.1210022 42.92200089 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.4489975 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.9489975 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.9240036 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.4240036 42.92200089 Tm [(non-exchangeable)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.46200562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.96200562 42.92200089 Tm [(site)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.98300171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.48300171 42.92200089 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.75100708 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.25100708 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.2519989 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.7519989 42.92200089 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.38600159 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.88598633 42.92200089 Tm [(cha)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(in.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.10700035 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 63.15000153 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 79.5 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TUBA1B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.78300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.84999847 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(TUBA1B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.1289978 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 112.19999695 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(tub)1(u)-1(lin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.52899933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.02899933 11.72200012 Tm [(alph)1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.6629982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.1629982 11.72200012 Tm [(1b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.18900299 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 128.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(K-)1(ALPHA-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.52899933 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P68)-1(36)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 161.25 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.47100067 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.97100067 19.52199936 Tm [(positive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.80799866 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.30799866 19.52199936 Tm [(control:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 96.39399719 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 31.95000076 l 141.67500305 31.95000076 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hu)-1(ma)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.45999908 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.95999908 11.72200012 Tm [(pro)1(sta)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.81900024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.31900024 11.72200012 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.40899658 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.90899658 11.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.18599701 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.68600464 11.72200012 Tm [(Hu)-1(ma)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.14599609 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.64599609 11.72200012 Tm [(colorec)-1(t)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.77600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.27600098 11.72200012 Tm [(canc)-1(er;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.53199768 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.03199768 11.72200012 Tm [(Hu)-1(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 27.3220005 Tm [(bra)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.14599991 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 193.19999695 cm q /GS2 gs 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.47100067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.97100067 11.72200012 Tm [(Recommend)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.78299713 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.28299713 11.72200012 Tm [(di)1(lution:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 120.1289978 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(10)-1(0-50)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.56100082 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 209.55001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 0.75 m 141.30000305 63.15000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 63.90000153 m 141.30000305 79.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 80.25 m 141.30000305 95.84999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 96.59999847 m 141.30000305 112.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 112.94999695 m 141.30000305 128.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 129.30000305 m 141.30000305 144.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 145.65000916 m 141.30000305 161.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 162.00001526 m 141.30000305 193.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 193.95001221 m 141.30000305 209.55001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 209.55001831 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 63.52500153 m 422.42498779 63.52500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.875 m 422.42498779 79.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 96.22499847 m 422.42498779 96.22499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 112.57499695 m 422.42498779 112.57499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.92500305 m 422.42498779 128.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 145.27500916 m 422.42498779 145.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 161.62501526 m 422.42498779 161.62501526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 193.57501221 m 422.42498779 193.57501221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.92501831 m 423.17498779 209.92501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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