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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 148.66200256 23.67700005 Tm 0 g [(CC)-1(N)1(D)-1(1)] TJ ET EMC /P <</MCID 1 >> BDC BT 1 0 0 -1 211.46099854 23.67700005 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 222.46099854 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 266.63699341 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<00050006000700080009>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(CCND1)] TJ ET EMC /P <</MCID 7 >> BDC BT 1 0 0 -1 92.75700378 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 98.00700378 12.82499981 Tm [<00030004>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 119.00700378 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 124.25700378 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A0006000700080009>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CCND1)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 92.75700378 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 95.1309967 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 128.33299255 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 17 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E0009>] TJ ET EMC /P <</MCID 18 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 21 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 24 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<00100009>] TJ ET EMC /P <</MCID 25 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 26 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001100120013>] TJ ET EMC /P <</MCID 27 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 28 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00140015>] TJ ET EMC /P <</MCID 29 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 180.95599365 m 416.75 180.95599365 l 416.75 212.1559906 l -1.45000005 212.1559906 l h f* Q q 1 0 0 1 0 180.95599365 cm /P <</MCID 31 >> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 32 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <</MCID 33 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 212.15600586 cm /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 240.09500122 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 35 >> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Synth)-1(e)1(ti)-1(c)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 34.04399872 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 36.07899857 12.04500008 Tm [(pepti)-1(de)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 64.3010025 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 66.33599854 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 119.1230011 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 121.15799713 12.04500008 Tm [(to)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 128.91900635 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 130.95399475 12.04500008 Tm [(a)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 135.26499939 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 137.30000305 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 160.69200134 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 162.727005 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 190.40800476 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 192.44299316 12.04500008 Tm [(from)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 210.26300049 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 212.29800415 12.04500008 Tm [(255-2)1(70)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 242.42300415 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 244.45799255 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 267.49899292 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 269.53399658 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 287.96499634 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 290 12.04500008 Tm [(of)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 297.49301147 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 299.52801514 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 325.21398926 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 327.24899292 12.04500008 Tm [(Cycli)-1(n)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 348.7869873 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 350.82199097 12.04500008 Tm [(D1)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 360.92098999 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 269.03399658 cm /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 296.97299194 m 416.75 296.97299194 l 416.75 328.17300415 l -1.45000005 328.17300415 l h f* Q q 1 0 0 1 0 296.97299194 cm /P <</MCID 66 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 328.17300415 cm /P <</MCID 69 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 356.11199951 cm q /GS2 gs 1 g 0.375 0.75 m 121.02500153 0.75 l 121.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 122.02500153 -0.25 l 122.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 70 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name)] TJ ET EMC /P <</MCID 73 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 45.78699875 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.77500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.77500153 16.35000038 l h f* Q q 1 0 0 1 121.40000153 0 cm -0.625 -0.25 m 302.0249939 -0.25 l 302.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 74 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Cyc)-1(lin)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 25.63299942 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 30.13299942 11.72200012 Tm [(D1)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 42.26599884 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 121.02500153 0.75 l 121.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 122.02500153 -0.25 l 122.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 78 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms)] TJ ET EMC /P <</MCID 79 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.60800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.77500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.77500153 16.35000038 l h f* Q q 1 0 0 1 121.40000153 0 cm -0.625 -0.25 m 302.0249939 -0.25 l 302.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 80 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BCL)-1(1,)] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 23.72999954 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 28.22999954 11.72200012 Tm [(PRA)1(D1,)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 60.24399948 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 64.7440033 11.72200012 Tm [(U21B)-1(31)-1(,)] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 100.38800049 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 104.88800049 11.72200012 Tm [(D11)-1(S28)-1(7E)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 148.2749939 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 121.02500153 0.75 l 121.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 122.02500153 -0.25 l 122.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 88 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot)] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 44.07699966 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.77500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.77500153 16.35000038 l h f* Q q 1 0 0 1 121.40000153 0 cm -0.625 -0.25 m 302.0249939 -0.25 l 302.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P24)-1(38)-1(5)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 121.02500153 0.75 l 121.02500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 122.02500153 -0.25 l 122.02500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 92 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n)] TJ ET EMC /P <</MCID 95 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 72.29399872 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.77500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.77500153 16.35000038 l h f* Q q 1 0 0 1 121.40000153 0 cm -0.625 -0.25 m 302.0249939 -0.25 l 302.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 96 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(00)-1(07)-1(6)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 121.02500153 0.75 l 121.02500153 187.94999695 l 0.375 187.94999695 l h f* Q q -0.625 -0.25 m 122.02500153 -0.25 l 122.02500153 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 98 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)] TJ ET EMC /P <</MCID 99 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 54.72100067 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.77500153 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 121.77500153 187.94999695 l h f* Q q 1 0 0 1 121.40000153 0 cm -0.625 -0.25 m 302.0249939 -0.25 l 302.0249939 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 100 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(belongs)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 193.54499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 198.04499817 11.72200012 Tm [(to)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 207.11999512 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 211.61999512 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 225.6210022 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 230.1210022 11.72200012 Tm [(hig)1(hly)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 256.51501465 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 261.01501465 11.72200012 Tm [(conse)-1(r)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ved)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 15.58699989 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 20.08699989 27.3220005 Tm [(cy)-1(clin)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 44.21300125 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 48.71300125 27.3220005 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 76.96099854 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 81.46099854 27.3220005 Tm [(wh)1(ose)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 109.10299683 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 113.60299683 27.3220005 Tm [(members)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 154.03300476 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 158.53300476 27.3220005 Tm [(are)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 172.05099487 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 176.55099487 27.3220005 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 234.08399963 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 238.58399963 27.3220005 Tm [(by)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 249.09599304 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 253.59599304 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 258.5710144 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 263.0710144 27.3220005 Tm [(dr)1(ama)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(tic)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 10.26099968 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 14.76099968 42.92200089 Tm [(period)1(i)-1(city)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 60.34500122 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 64.84500122 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 72.78600311 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 77.28600311 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 108.59300232 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 113.09300232 42.92200089 Tm [(ab)1(u)-1(nd)1(anc)-1(e)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 160.80400085 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 165.30400085 42.92200089 Tm [(th)1(rough)1(out)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 214.82200623 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 219.32200623 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 233.32299805 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 237.82299805 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 252.23300171 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 256.73300171 42.92200089 Tm [(cy)-1(cle)-1(.)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 280.19100952 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 284.69100952 42.92200089 Tm [(C)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(yc)-1(lins)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 23.77899933 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 28.27899933 58.52199936 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 64.01999664 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 68.51999664 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 77.66100311 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 82.16100311 58.52199936 Tm [(regulat)1(ors)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 126.05400085 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 130.55400085 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 139.39599609 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 143.89599609 58.52199936 Tm [(CDK)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 162.48500061 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 166.98500061 58.52199936 Tm [(ki)-1(na)1(se)-1(s.)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 200.40499878 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 204.90499878 58.52199936 Tm [(Diff)1(e)-1(r)1(e)-1(nt)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 242.94400024 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 247.44400024 58.52199936 Tm [(cy)-1(clin)-1(s)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 275.73599243 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 280.23599243 58.52199936 Tm [(ex)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(hibit)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 19.43300056 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 23.93300056 74.12200165 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 55.4109993 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 59.9109993 74.12200165 Tm [(expression)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 105.86499786 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 110.36499786 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 126.64199829 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 131.14199829 74.12200165 Tm [(degra)1(dat)1(ion)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 183.91999817 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 188.41999817 74.12200165 Tm [(pa)1(tterns)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 224.10400391 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 228.60400391 74.12200165 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 253.70100403 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 258.20098877 74.12200165 Tm [(contrib)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ute)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 14.00500011 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 18.50499916 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 27.57999992 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 32.08000183 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 46.08100128 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 50.58100128 89.72200012 Tm [(tempo)1(ral)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 89.74900055 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 94.24900055 89.72200012 Tm [(coord)1(i)-1(na)1(tion)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 149.33000183 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 153.83000183 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 162.67199707 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 167.17199707 89.72200012 Tm [(eac)-1(h)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 187.30799866 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 191.80799866 89.72200012 Tm [(mito)1(tic)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 221.97200012 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 226.47200012 89.72200012 Tm [(eve)-1(nt)1(.)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 252.47399902 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 256.97399902 89.72200012 Tm [(This)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 274.23599243 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 278.73599243 89.72200012 Tm [(cy)-1(c)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(lin)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 10.33600044 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 14.83600044 105.3219986 Tm [(fo)1(rms)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 39.71300125 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 44.21300125 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 49.18799973 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 53.68799973 105.3219986 Tm [(complex)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 90.16699982 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 94.66699982 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 113.06300354 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 117.56300354 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 133.83999634 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 138.33999634 105.3219986 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 178.24699402 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 182.74699402 105.3219986 Tm [(as)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 191.88800049 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 196.38800049 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 201.36300659 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 205.86300659 105.3219986 Tm [(regulat)1(ory)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 250.35299683 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 254.85299683 105.3219986 Tm [(subunit)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 287.15301514 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 8.84200001 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 13.34200001 120.92199707 Tm [(CDK)1(4)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 37.20899963 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 41.70899963 120.92199707 Tm [(or)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 50.86700058 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 55.36700058 120.92199707 Tm [(CDK)1(6)-1(,)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 81.40000153 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 85.90000153 120.92199707 Tm [(wh)1(ose)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 113.54199982 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 118.04199982 120.92199707 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 148.51400757 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 153.01400757 120.92199707 Tm [(is)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 159.57499695 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 164.07499695 120.92199707 Tm [(required)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 200.61599731 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 205.11599731 120.92199707 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 217.39399719 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 221.89399719 120.92199707 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 236.30400085 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 240.80400085 120.92199707 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 262.0960083 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 266.5960083 120.92199707 Tm [(G1/S)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 287.60598755 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(tr)1(ansition.)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 43.0530014 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 47.5530014 136.52200317 Tm [(This)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 64.81500244 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 69.31500244 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 100.62200165 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 105.12200165 136.52200317 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 119.80400085 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 124.30400085 136.52200317 Tm [(been)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 145.81100464 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 150.31100464 136.52200317 Tm [(sho)1(wn)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 178.39199829 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 182.89199829 136.52200317 Tm [(to)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 191.96699524 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 196.46699524 136.52200317 Tm [(interact)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 229.14500427 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 233.64500427 136.52200317 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 252.04100037 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 256.54098511 136.52200317 Tm [(tumor)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 283.03100586 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 287.53100586 136.52200317 Tm [(s)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(uppr)1(e)-1(sso)1(r)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 43.07500076 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 47.57500076 152.12199402 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 78.88200378 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 83.38200378 152.12199402 Tm [(Rb)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 95.0059967 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 99.5059967 152.12199402 Tm [(and)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 115.78299713 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 120.28299713 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 134.28399658 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 138.78399658 152.12199402 Tm [(expression)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 184.73800659 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 189.23800659 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 198.08000183 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 202.58000183 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 218.03599548 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 222.53599548 152.12199402 Tm [(gene)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 244.05200195 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 248.55200195 152.12199402 Tm [(is)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 255.11300659 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 259.61300659 152.12199402 Tm [(regulat)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ed)] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 10.86299992 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 15.36299992 167.72200012 Tm [(po)1(sitively)] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 56.13100052 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 60.63100052 167.72200012 Tm [(by)] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 71.14299774 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 75.64299774 167.72200012 Tm [(Rb.)] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 89.43299866 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 93.93299866 167.72200012 Tm [(Mutat)1(ions,)] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 139.94799805 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 312 >> BDC BT 1 0 0 -1 144.44799805 167.72200012 Tm [(amp)1(l)-1(if)1(ic)-1(at)1(ion)] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 200.41200256 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 314 >> BDC BT 1 0 0 -1 204.91200256 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 315 >> BDC BT 1 0 0 -1 221.18899536 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 316 >> BDC BT 1 0 0 -1 225.68899536 167.72200012 Tm [(overexpression)] TJ ET EMC /P <</MCID 317 >> BDC BT 1 0 0 -1 290.63101196 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 318 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(of)] TJ ET EMC /P <</MCID 319 >> BDC BT 1 0 0 -1 8.84200001 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 320 >> BDC BT 1 0 0 -1 13.34200001 183.32200623 Tm [(th)1(is)] TJ ET EMC /P <</MCID 321 >> BDC BT 1 0 0 -1 28.79800034 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 322 >> BDC BT 1 0 0 -1 33.29800034 183.32200623 Tm [(gene)-1(,)] TJ ET EMC /P <</MCID 323 >> BDC BT 1 0 0 -1 56.97999954 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 324 >> BDC BT 1 0 0 -1 61.47999954 183.32200623 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 325 >> BDC BT 1 0 0 -1 86.57700348 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 326 >> BDC BT 1 0 0 -1 91.07700348 183.32200623 Tm [(alt)1(e)-1(rs)] TJ ET EMC /P <</MCID 327 >> BDC BT 1 0 0 -1 114.50900269 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 328 >> BDC BT 1 0 0 -1 119.00900269 183.32200623 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 329 >> BDC BT 1 0 0 -1 133.41900635 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 330 >> BDC BT 1 0 0 -1 137.91900635 183.32200623 Tm [(cy)-1(cle)] TJ ET EMC /P <</MCID 331 >> BDC BT 1 0 0 -1 159.21099854 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 332 >> BDC BT 1 0 0 -1 163.71099854 183.32200623 Tm [(pro)1(gression,)] TJ ET EMC /P <</MCID 333 >> BDC BT 1 0 0 -1 217.07800293 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 334 >> BDC BT 1 0 0 -1 221.57800293 183.32200623 Tm [(are)] TJ ET EMC /P <</MCID 335 >> BDC BT 1 0 0 -1 235.09599304 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 336 >> BDC BT 1 0 0 -1 239.59599304 183.32200623 Tm [(ob)1(se)-1(rv)1(e)-1(d)] TJ ET EMC /P <</MCID 337 >> BDC BT 1 0 0 -1 279.36199951 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 338 >> BDC BT 1 0 0 -1 283.86199951 183.32200623 Tm [(fr)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 253.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 121.40000153 0.75 m 121.40000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 121.40000153 17.10000038 m 121.40000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 121.40000153 33.45000076 m 121.40000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 121.40000153 49.80000305 m 121.40000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 121.40000153 66.15000153 m 121.40000153 253.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 253.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 253.7250061 m 423.17498779 253.7250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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