%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 133 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 88 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(TSPAN7)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 149.23699951 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 259.67700195 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(TS)-1(P)1(AN7)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 122.79100037 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.29100037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.54100037 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TSPAN)1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.27400208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.64800262 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.41999817 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.79400635 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.11500549 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.48899841 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.28500366 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tet)1(rasp)-1(ani)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.04399872 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.5510025 12.82499981 Tm [(7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.68199921 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.18900299 12.82499981 Tm [(A1)1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.71800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.2250061 12.82499981 Tm [(MXS1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.60800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.11500549 12.82499981 Tm [(CD231;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.94799805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.45500183 12.82499981 Tm [(MRX58;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.03700256 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.54400635 12.82499981 Tm [(CCG-B7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.42300415 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.92999268 12.82499981 Tm [(TM4S)-1(F2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.12600708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 331.63299561 12.82499981 Tm [(TALL)-1(A)1(-)-1(1)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 369.07501221 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 372.58200073 12.82499981 Tm [(TM4S)-1(F2b;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29501343 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(DXS)-1(16)1(92E)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.14799881 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TS)-1(P)1(AN7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.54100037 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002300240025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 431.32901001 cm q 1 g 0.375 0.75 m 137.92500305 0.75 l 137.92500305 187.94999695 l 0.375 187.94999695 l h f* Q q -0.625 -0.25 m 138.92500305 -0.25 l 138.92500305 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 97.52200317 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 138.67500305 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 138.67500305 187.94999695 l h f* Q q 1 0 0 1 138.30000305 0 cm -0.625 -0.25 m 285.125 -0.25 l 285.125 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(tr)1(ans)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.7840004 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.2840004 27.3220005 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.56200027 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.06200027 27.3220005 Tm [(superfa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.31300354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.81300354 27.3220005 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.07000732 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.57000732 27.3220005 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.38900757 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.88900757 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.02999878 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.52999878 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.53100586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.03100586 27.3220005 Tm [(tetr)1(aspa)1(n)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.63000488 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.13000488 27.3220005 Tm [(fa)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ily)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.72000027 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.21999931 42.92200089 Tm [(Most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.25400162 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.75400162 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.59600067 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.09600067 42.92200089 Tm [(th)1(e)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.3690033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.8690033 42.92200089 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.2990036 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.79899597 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.31700134 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.81700134 42.92200089 Tm [(ce)-1(ll-surf)1(ac)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.98300171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.48300171 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.95599365 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.45599365 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.67800903 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.17800903 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.6960144 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.53300095 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.03300095 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.54499817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.04499817 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.04599762 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54599762 58.52199936 Tm [(presenc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.2749939 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.7749939 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.61700439 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.11700439 58.52199936 Tm [(fo)1(u)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.94099426 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.44099426 58.52199936 Tm [(hydro)1(pho)1(bic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.32899475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.82899475 58.52199936 Tm [(do)1(mains.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.98901367 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 74.12200165 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.77999878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.27999878 74.12200165 Tm [(mediat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.40499878 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.90499878 74.12200165 Tm [(signal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.13800049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.63800049 74.12200165 Tm [(tr)1(ansduc)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.94599915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.44599915 74.12200165 Tm [(eve)-1(nt)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.44799805 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.94799805 74.12200165 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.16999817 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.66999817 74.12200165 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.55099487 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.05099487 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.02600098 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.65999985 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.15999985 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.10099983 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.60100174 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.60200119 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.10200119 89.72200012 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.33300018 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.83300018 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.67500305 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.17500305 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58500671 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08500671 89.72200012 Tm [(development,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.24899292 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.74899292 89.72200012 Tm [(activat)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.86599731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.36599731 89.72200012 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.28201294 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.27700043 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.77700043 105.3219986 Tm [(mot)1(il)-1(it)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.75299835 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.25299835 105.3219986 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.51499939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.01499939 105.3219986 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.52200317 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.02200317 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.32899475 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.82899475 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.38999939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.88999939 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.86500549 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.36500549 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.7749939 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.2749939 105.3219986 Tm [(surfa)1(c)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.13800049 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.63800049 105.3219986 Tm [(glyc)-1(o)1(prot)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.04699993 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.54700089 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.82400131 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.32400131 120.92199707 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.49499893 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.99499893 120.92199707 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.34200287 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.84200287 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.81700134 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.31700134 120.92199707 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.97699738 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.47699738 120.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.41799927 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.91799927 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.91900635 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.41900635 120.92199707 Tm [(control)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.10600281 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.60600281 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.44799805 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.94799805 120.92199707 Tm [(ne)-1(urit)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.43699646 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.93699646 120.92199707 Tm [(outg)1(row)1(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.66699982 136.52200317 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.66600037 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.16600037 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.72699928 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.22699928 136.52200317 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.04600143 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.54600143 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.6210022 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.1210022 136.52200317 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.59999847 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.09999847 136.52200317 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.4960022 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.9960022 136.52200317 Tm [(integrins.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.86300659 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.36300659 136.52200317 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.625 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.125 136.52200317 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.64100647 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.14100647 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.70199585 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.20199585 136.52200317 Tm [(asso)1(c)-1(iat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.75899887 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.25899887 152.12199402 Tm [(X-link)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.05699921 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.55699921 152.12199402 Tm [(cognitive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.06800079 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.56800079 152.12199402 Tm [(disa)1(bility)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.91000366 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.41000366 152.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.68699646 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.18699646 152.12199402 Tm [(ne)-1(uro)1(psyc)-1(h)1(i)-1(a)1(tric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.34298706 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.84298706 152.12199402 Tm [(dis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(eases)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.52000046 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.02000046 167.72200012 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.78699875 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.28699875 167.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.4280014 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.9280014 167.72200012 Tm [(Hu)-1(nt)1(i)-1(ng)1(ton's)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.125 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.625 167.72200012 Tm [(chorea,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.08500671 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.58500671 167.72200012 Tm [(fra)1(gile)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.77000427 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.27000427 167.72200012 Tm [(X)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.07499695 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.57499695 167.72200012 Tm [(syndrome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.50500488 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.00500488 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.28201294 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(myoto)1(n)-1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.4469986 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.9469986 183.32200623 Tm [(dyst)1(roph)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.36399841 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 138.30000305 0.75 m 138.30000305 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 188.32499695 m 423.17498779 188.32499695 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>