%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 127 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 18 Tf 1 0 0 -1 116.22399902 22.20999908 Tm 2 Tr 0 g 0.51428574 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 18 Tf 1 0 0 -1 174.94000244 22.20999908 Tm 0 Tr [(TSN)] TJ ET EMC /P <> BDC BT /FAAABB 18 Tf 1 0 0 -1 208.71600342 22.20999908 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 18 Tf 1 0 0 -1 299.07598877 22.20999908 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TS)-1(N)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 116.46900177 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 168.96899414 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.21899414 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TSN)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.45200348 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.8259964 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.5980072 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.97200012 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.29299927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.66700745 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.46299744 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(transl)-1(in;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.97599792 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.34999847 12.82499981 Tm [(C3PO;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.45600128 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.83000183 12.82499981 Tm [(RCHF)-1(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.62800598 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.0019989 12.82499981 Tm [(TBRBP;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.477005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.85099792 12.82499981 Tm [(TRS)-1(LN;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.49499512 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.8690033 12.82499981 Tm [(BCL)-1(F-1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.76400757 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.13800049 12.82499981 Tm [(REHF)-1(-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.86898804 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TS)-1(N)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.71900177 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q /GS2 gs 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 105.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 140.17500305 203.55000305 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(DNA)1(-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.21200562 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.71200562 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.01899719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.51899719 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.61599731 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.11599731 11.72200012 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.60101318 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(rec)-1(o)1(gnizes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.17300034 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.67300034 27.3220005 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.75 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.25 27.3220005 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.23000336 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.72999573 27.3220005 Tm [(seque)-1(nce)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.74299622 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.24299622 27.3220005 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.57099915 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.07099915 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.07200623 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.57200623 27.3220005 Tm [(breakpo)1(i)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.50100708 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.00100708 27.3220005 Tm [(jun)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ction)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.52899933 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.02899933 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.87099838 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.37099838 42.92200089 Tm [(chromos)1(omal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.42900085 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.92900085 42.92200089 Tm [(tr)1(ansloc)-1(a)1(tions.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.35800171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.85800171 42.92200089 Tm [(Translin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.47599792 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.97599792 42.92200089 Tm [(po)1(l)-1(yp)1(e)-1(pt)1(ides)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.98400879 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.48400879 42.92200089 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(orm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.5909996 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.0909996 58.52199936 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.06599998 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.56599998 58.52199936 Tm [(multimeric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.5719986 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.0719986 58.52199936 Tm [(st)1(ruc)-1(ture)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.52899933 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.02899933 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.25100708 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.75100708 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.31199646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.81199646 58.52199936 Tm [(responsib)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.34700012 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.84700012 58.52199936 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.125 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.625 58.52199936 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.53900146 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.03900146 58.52199936 Tm [(DNA)1(-b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(inding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.39599991 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 74.12200165 Tm [(activit)1(y)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.53399658 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.03399658 74.12200165 Tm [(Rec)-1(o)1(mbination-)1(associated)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.38400269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.88400269 74.12200165 Tm [(mot)1(ifs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.07299805 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.57299805 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.8500061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.3500061 74.12200165 Tm [(tr)1(anslin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(-b)1(in)-1(d)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.03699875 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.53699875 89.72200012 Tm [(sites)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.72399902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.22399902 89.72200012 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.74199677 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.24199677 89.72200012 Tm [(present)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.70400238 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.20400238 89.72200012 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.53199768 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.03199768 89.72200012 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.92199707 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.42199707 89.72200012 Tm [(ho)1(tspo)1(ts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.19299316 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.69299316 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.97000122 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.47000122 89.72200012 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ay)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.73799992 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.23799992 105.3219986 Tm [(serve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.77799988 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.27799988 105.3219986 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.41899872 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.91899872 105.3219986 Tm [(indic)-1(a)1(tor)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.17700195 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.67700195 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.51899719 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.01899719 105.3219986 Tm [(breakpo)1(i)-1(nt)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.11399841 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.61399841 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.55499268 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.05499268 105.3219986 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.73699951 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.23699951 105.3219986 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.33399963 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.83399963 105.3219986 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.35198975 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.85198975 105.3219986 Tm [(fus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.875 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.375 120.92199707 Tm [(tr)1(ansloc)-1(a)1(tions.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.80400085 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.30400085 120.92199707 Tm [(These)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.38400269 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.88400269 120.92199707 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.02799988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.52799988 120.92199707 Tm [(activit)1(i)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.90299988 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.40299988 120.92199707 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.57400513 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.07400513 120.92199707 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.95500183 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.45500183 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.42999268 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.92999268 120.92199707 Tm [(cru)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ci)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.27799988 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.77799988 136.52200317 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.43799973 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.93799973 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.87900162 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.37900162 136.52200317 Tm [(chromos)1(omal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.43699646 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.93699646 136.52200317 Tm [(tr)1(ansloc)-1(a)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.03300476 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.53300476 136.52200317 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.47399902 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.97399902 136.52200317 Tm [(lymphoid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.72900391 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.22900391 136.52200317 Tm [(ne)-1(o)1(plas)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ms.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.76599979 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.26600075 152.12199402 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.52799988 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.02799988 152.12199402 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.33499908 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.83499908 152.12199402 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.34200287 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.84200287 152.12199402 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.35400391 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.85400391 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.30999756 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.80999756 152.12199402 Tm [(gene)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.49200439 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.99200439 152.12199402 Tm [(wh)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.29200745 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.79200745 152.12199402 Tm [(complexe)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.13400269 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.63400269 152.12199402 Tm [(wit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 167.72200012 Tm [(tr)1(anslin)-1(-)1(associat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.875 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.375 167.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.68199921 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.18200684 167.72200012 Tm [(X,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.15400696 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.65400696 167.72200012 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.91099548 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.41099548 167.72200012 Tm [(fo)1(rms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.28799438 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.78799438 167.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.76300049 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.26300049 167.72200012 Tm [(Mg)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.81300354 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.31300354 167.72200012 Tm [(ion-d)1(e)-1(p)1(e)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(en)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.00500011 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.50499916 183.32200623 Tm [(en)-1(d)1(oribo)1(n)-1(ucle)-1(a)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.29100037 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.79100037 183.32200623 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.01300049 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.51300049 183.32200623 Tm [(pro)1(motes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.19999695 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.69999695 183.32200623 Tm [(RNA)1(-induc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.73899841 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.23899841 183.32200623 Tm [(sile)-1(ncing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.05801392 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.47900009 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97900009 198.92199707 Tm [(\(RISC\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.72699738 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.22699738 198.92199707 Tm [(activat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.34400177 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.84400177 198.92199707 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.56700134 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.06700134 198.92199707 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.98199463 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.48199463 198.92199707 Tm [(results)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.65100098 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.15100098 198.92199707 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.09199524 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.59199524 198.92199707 Tm [(mult)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 0.75 m 139.80000305 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>