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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 89.33200073 23.67700005 Tm 0 g [(CC)-1(N)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.26300049 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 149.26300049 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 325.9670105 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(CCN3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.29699707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 91.54699707 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.54699707 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CCN3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.29699707 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.67099762 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.8730011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.24700165 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.227005 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.60099792 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.07499695 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(ce)1(l)-1(lu)-1(lar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.09999847 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.47399902 12.82499981 Tm [(commun)-1(icatio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.1190033 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.49299622 12.82499981 Tm [(network)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.22799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.602005 12.82499981 Tm [(factor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.99099731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.36500549 12.82499981 Tm [(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.4960022 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.86999512 12.82499981 Tm [(NOV;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.36700439 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 266.74099731 12.82499981 Tm [(NOVh;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.75500488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.1289978 12.82499981 Tm [(IBP-9)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 322.25601196 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.63000488 12.82499981 Tm [(IGFBP9;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.99099731 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 360.36499023 12.82499981 Tm [(IGFBP-9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 394.13101196 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(108-3)1(57)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(CCN3)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 335.7749939 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 136.67500305 0.75 l 136.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.67500305 -0.25 l 137.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.42500305 16.35000038 l h f* Q q 1 0 0 1 137.05000305 0 cm -0.625 -0.25 m 290.125 -0.25 l 290.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.76199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.26200104 11.72200012 Tm [(commun)-1(icatio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.35299683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.85299683 11.72200012 Tm [(ne)-1(t)1(wo)1(rk)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.02200317 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.52200317 11.72200012 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.64100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.14100647 11.72200012 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.41900635 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 136.67500305 0.75 l 136.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.67500305 -0.25 l 137.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.42500305 16.35000038 l h f* Q q 1 0 0 1 137.05000305 0 cm -0.625 -0.25 m 290.125 -0.25 l 290.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(NOV;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.90399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [(NOVh;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.84999847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.34999847 11.72200012 Tm [(IBP-9;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.48699951 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.98699951 11.72200012 Tm [(IGFBP9)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.70400238 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.20400238 11.72200012 Tm [(IGFBP-9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.647995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 136.67500305 0.75 l 136.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.67500305 -0.25 l 137.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.42500305 16.35000038 l h f* Q q 1 0 0 1 137.05000305 0 cm -0.625 -0.25 m 290.125 -0.25 l 290.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P48)-1(74)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 136.67500305 0.75 l 136.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.67500305 -0.25 l 137.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.42500305 16.35000038 l h f* Q q 1 0 0 1 137.05000305 0 cm -0.625 -0.25 m 290.125 -0.25 l 290.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(15)-1(02)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 136.67500305 0.75 l 136.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.67500305 -0.25 l 137.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.42500305 16.35000038 l h f* Q q 1 0 0 1 137.05000305 0 cm -0.625 -0.25 m 290.125 -0.25 l 290.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 136.67500305 0.75 l 136.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.67500305 -0.25 l 137.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.42500305 16.35000038 l h f* Q q 1 0 0 1 137.05000305 0 cm -0.625 -0.25 m 290.125 -0.25 l 290.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 136.67500305 0.75 l 136.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.67500305 -0.25 l 137.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.42500305 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.42500305 16.35000038 l h f* Q q 1 0 0 1 137.05000305 0 cm -0.625 -0.25 m 290.125 -0.25 l 290.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 136.67500305 0.75 l 136.67500305 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 137.67500305 -0.25 l 137.67500305 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.42500305 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 137.42500305 94.34999847 l h f* Q q 1 0 0 1 137.05000305 0 cm -0.625 -0.25 m 290.125 -0.25 l 290.125 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(small)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.00500488 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.50500488 11.72200012 Tm [(sec)-1(reted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.05000305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.55000305 11.72200012 Tm [(cy)-1(st)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(e-rich)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.88599968 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.38599968 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.69300079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.19300079 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.47000122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.97000122 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.94499969 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.44499969 27.3220005 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.70899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.20899963 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.05099487 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.55099487 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.55200195 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.05200195 27.3220005 Tm [(CCN)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.41000366 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.91000366 27.3220005 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.99200439 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.49200439 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.33399963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.83399963 27.3220005 Tm [(regulat)1(ory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.32400513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.63899994 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.13899994 42.92200089 Tm [(CNN)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.79299927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.29299927 42.92200089 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.375 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.875 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.3480072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.8480072 42.92200089 Tm [(asso)1(c)-1(iat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.21899414 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.71899414 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.11500549 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.61500549 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.61599731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.11599731 42.92200089 Tm [(extra)1(c)-1(ellu)-1(la)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.30999756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(mat)1(rix)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.15399933 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.65399933 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.93099976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.43099976 58.52199936 Tm [(play)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.31199646 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.81199646 58.52199936 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.33300018 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.83300018 58.52199936 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.79400635 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.29400635 58.52199936 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.95399475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.45399475 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.39500427 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.89500427 58.52199936 Tm [(cardiov)1(asc)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.42300415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.92300415 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.19999695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.70001221 58.52199936 Tm [(ske)-1(le)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ta)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.72299957 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.22299957 74.12200165 Tm [(development,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.38700104 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.88700104 74.12200165 Tm [(fib)1(rosis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.03500366 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.53500366 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.81199646 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.31199646 74.12200165 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.4019928 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.9019928 74.12200165 Tm [(development.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.06599426 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.56599426 74.12200165 Tm [([pr)1(ovided)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.2170105 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.51200008 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.01200008 89.72200012 Tm [(RefSeq,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.33800125 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.83800125 89.72200012 Tm [(Fe)-1(b)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.47399902 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.97399902 89.72200012 Tm [(20)-1(09)-1(])] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.09100342 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.05000305 0.75 m 137.05000305 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.05000305 17.10000038 m 137.05000305 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.05000305 33.45000076 m 137.05000305 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.05000305 49.80000305 m 137.05000305 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.05000305 66.15000153 m 137.05000305 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.05000305 82.5 m 137.05000305 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.05000305 98.84999847 m 137.05000305 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.05000305 115.19999695 m 137.05000305 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92498779 209.17498779 l S Q Q q 1 0 0 1 0 592.67901611 cm Q Q 1 0 0 -1 0 841.90002441 cm
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