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Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(TS)-1(C22D4)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 127.21499634 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.71499634 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 184.96499634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TSC)-1(2)1(2D4)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 121.69799805 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 124.0719986 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 152.84399414 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 155.21800232 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 205.53900146 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 207.91299438 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 245.70899963 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000C000E>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TS)-1(C22)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 89.18299866 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 91.55699921 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 123.95400238 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 126.32800293 12.82499981 Tm [(fami)-1(ly)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 152.52200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 154.89599609 12.82499981 Tm [(me)1(mb)-1(e)1(r)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 191.29699707 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 193.67100525 12.82499981 Tm [(4;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 201.80200195 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 204.17599487 12.82499981 Tm [(THG1;)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 230.58999634 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 232.96400452 12.82499981 Tm [(THG-1;)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 262.59298706 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 264.9670105 12.82499981 Tm [(TIL)-1(Z2)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 287.38198853 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000E>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000E>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000E>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TS)-1(C22D4)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 100.96499634 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 66 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001F002000210022000E>] TJ ET EMC /P <</MCID 67 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002300240025000E>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 75 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130026000E>] TJ ET EMC /P <</MCID 76 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 81 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 82 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 83 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 63.15000153 l 0.375 63.15000153 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 84 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 35.12200165 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 85 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 35.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 63.15000153 l 143.17500305 63.15000153 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 64.15000153 l -0.625 64.15000153 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 86 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(TSC2)-1(2D4)] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 39.06299973 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 43.56299973 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 50.12400055 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 54.62400055 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 59.59899902 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 64.09899902 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 100.36299896 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 104.86299896 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 113.70500183 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 118.20500183 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 132.20599365 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 136.70599365 11.72200012 Tm [(TSC2)-1(2)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 163.63600159 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 168.13600159 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 200.96299744 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 205.46299744 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 231.54499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 236.04499817 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 244.88699341 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 249.38699341 11.72200012 Tm [(leu)-1(ci)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ne)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 10.65200043 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 15.15200043 27.3220005 Tm [(zip)1(pe)-1(r)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 42.01100159 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 46.51100159 27.3220005 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 108.46499634 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 112.96499634 27.3220005 Tm [(regulat)1(ors)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 156.85800171 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 161.35800171 27.3220005 Tm [(\(see)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 178.74299622 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 183.24299622 27.3220005 Tm [(TSC2)-1(2D3;)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 224.47200012 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 228.97200012 27.3220005 Tm [(MIM)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 249.20399475 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 253.70399475 27.3220005 Tm [(30)-1(0)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(50)-1(6\))] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 18.8390007 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 23.3390007 42.92200089 Tm [(\(Kester)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 53.22600174 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 57.72600174 42.92200089 Tm [(et)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 66.18499756 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 70.68499756 42.92200089 Tm [(al.,)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 82.38800049 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 86.88800049 42.92200089 Tm [(19)-1(99)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 107.99900055 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 112.49900055 42.92200089 Tm [([PubMed)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 151.96200562 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 156.46200562 42.92200089 Tm [(10)-1(48)-1(80)-1(76];)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 203.85699463 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 208.35699463 42.92200089 Tm [(Fioren)-1(z)1(a)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 244.7440033 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 249.2440033 42.92200089 Tm [(et)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 257.70300293 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 262.20300293 42.92200089 Tm [(al.)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(,)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 2.16700006 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 6.66699982 58.52199936 Tm [(20)-1(01)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 27.77799988 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 32.27799988 58.52199936 Tm [([PubMed)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 71.74099731 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 76.24099731 58.52199936 Tm [(11)-1(70)-1(73)-1(29]\).[supplied)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 166.50900269 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 171.00900269 58.52199936 Tm [(by)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 181.52099609 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 186.02099609 58.52199936 Tm [(OMIM,)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 215.7539978 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 220.2539978 58.52199936 Tm [(Mar)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 237.45899963 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 241.95899963 58.52199936 Tm [(20)-1(08)-1(])] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 266.07598877 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 63.15000153 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 157 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 158 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 159 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 79.5 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 161 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 166 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 167 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(TSC2)-1(2D4)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 39.06299973 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.84999847 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 169 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <</MCID 170 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 171 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(TSC2)-1(2D4)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 155.40899658 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 112.19999695 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 181 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 184 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 185 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(TSC2)-1(2)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 26.93000031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 31.43000031 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 64.25700378 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 68.75700378 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 94.83899689 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 99.33899689 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 135.60299683 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 140.10299683 11.72200012 Tm [(4)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 145.3809967 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 128.55000305 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 195 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 196 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 197 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(TH)-1(G)1(1)-1(;)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 26.25699997 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 30.75699997 11.72200012 Tm [(TH)-1(G)1(-1;)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 60.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 65.40799713 11.72200012 Tm [(TILZ2)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 88.69000244 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.8999939 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 203 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <</MCID 204 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 205 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Q9Y3Q8)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 35.93399811 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 161.25 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 207 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 15.8380003 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 20.33799934 11.72200012 Tm [(Predic)1(ted)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 63.54499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 68.04499817 11.72200012 Tm [(band)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 91.05000305 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 95.55000305 11.72200012 Tm [(siz)1(e:)] TJ ET EMC /P <</MCID 214 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 115.08799744 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 215 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(41)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 10.55599976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 15.05599976 11.72200012 Tm [(KD)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 27.62400055 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 177.6000061 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 219 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 15.8380003 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 20.33799934 11.72200012 Tm [(Positive)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 56.09600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 60.59600067 11.72200012 Tm [(control:)] TJ ET EMC /P <</MCID 224 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 95.68199921 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 225 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(He)-1(la,)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 21.60400009 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 26.10400009 11.72200012 Tm [(K56)-1(2)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 47.65000153 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 52.15000153 11.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 66.55999756 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 71.05999756 11.72200012 Tm [(lysates)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 99.98500061 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.95002747 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 0.75 m 142.80000305 63.15000153 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 63.90000153 m 142.80000305 79.5 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 80.25 m 142.80000305 95.84999847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 96.59999847 m 142.80000305 112.19999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 112.94999695 m 142.80000305 128.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 129.30000305 m 142.80000305 144.90000916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 145.65000916 m 142.80000305 161.25001526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 162.00001526 m 142.80000305 177.60002136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 178.35002136 m 142.80000305 193.95002747 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 193.95002747 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 63.52500153 m 422.42498779 63.52500153 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.875 m 422.42498779 79.875 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 96.22499847 m 422.42498779 96.22499847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 112.57499695 m 422.42498779 112.57499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.92500305 m 422.42498779 128.92500305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 145.27500916 m 422.42498779 145.27500916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 161.62501526 m 422.42498779 161.62501526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 177.97502136 m 422.42498779 177.97502136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 194.32502747 m 423.17498779 194.32502747 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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