%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 78.2460022 23.67700005 Tm 0 g [(CC)-1(DC47)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.34899902 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 160.34899902 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 337.05300903 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(CCD)-1(C47)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.89900208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 102.14900208 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 186.14900208 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CCD)-1(C47)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.89900208 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.27300262 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.4750061 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.84899902 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.82899475 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.20300293 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.67700195 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(coi)-1(led-coi)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.54799652 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.92199707 12.82499981 Tm [(do)-1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.31900024 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.69299316 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.52799988 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.9019928 12.82499981 Tm [(47;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.35499573 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.72900391 12.82499981 Tm [(GK)1(001;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.58299255 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.95700073 12.82499981 Tm [(MST)-1(P)1(041)] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.26501465 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 242.43400574 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 270.37298584 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(284-4)1(83)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(CCD)-1(C47)] TJ ET EMC /P <> BDC BT /FAAABB 9 Tf 1 0 0 -1 344.86300659 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 299.31201172 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 327.25100708 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 355.19000244 cm /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 383.1289978 cm q /GS2 gs 1 g 0.375 0.75 m 156.375 0.75 l 156.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 157.375 -0.25 l 157.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 157.125 16.35000038 l h f* Q q 1 0 0 1 156.75 0 cm -0.625 -0.25 m 270.42498779 -0.25 l 270.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(coile)-1(d)1(-c)-1(o)1(il)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.80699921 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.30699921 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.13400269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.63400269 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.3809967 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.8809967 11.72200012 Tm [(47)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.43699646 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 156.375 0.75 l 156.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 157.375 -0.25 l 157.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 157.125 16.35000038 l h f* Q q 1 0 0 1 156.75 0 cm -0.625 -0.25 m 270.42498779 -0.25 l 270.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(GK)1(0)-1(01)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.90599823 11.72200012 Tm [(MSTP0)-1(41)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.39299774 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 156.375 0.75 l 156.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 157.375 -0.25 l 157.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 157.125 16.35000038 l h f* Q q 1 0 0 1 156.75 0 cm -0.625 -0.25 m 270.42498779 -0.25 l 270.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q96)-1(A)1(3)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.77799988 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 156.375 0.75 l 156.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 157.375 -0.25 l 157.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 157.125 16.35000038 l h f* Q q 1 0 0 1 156.75 0 cm -0.625 -0.25 m 270.42498779 -0.25 l 270.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(08)-1(90)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 156.375 0.75 l 156.375 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 157.375 -0.25 l 157.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.125 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 157.125 31.95000076 l h f* Q q 1 0 0 1 156.75 0 cm -0.625 -0.25 m 270.42498779 -0.25 l 270.42498779 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(GE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.64099979 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 156.375 0.75 l 156.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 157.375 -0.25 l 157.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 157.125 16.35000038 l h f* Q q 1 0 0 1 156.75 0 cm -0.625 -0.25 m 270.42498779 -0.25 l 270.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 113.69999695 cm q /GS2 gs 1 g 0.375 0.75 m 156.375 0.75 l 156.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 157.375 -0.25 l 157.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 157.125 16.35000038 l h f* Q q 1 0 0 1 156.75 0 cm -0.625 -0.25 m 270.42498779 -0.25 l 270.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 130.05000305 cm q /GS2 gs 1 g 0.375 0.75 m 156.375 0.75 l 156.375 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 157.375 -0.25 l 157.375 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 157.125 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 157.125 94.34999847 l h f* Q q 1 0 0 1 156.75 0 cm -0.625 -0.25 m 270.42498779 -0.25 l 270.42498779 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(coile)-1(d)1(-c)-1(o)1(il)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.11399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.61399841 11.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.44100189 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.94100189 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.5019989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.0019989 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.97699738 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.47699738 11.72200012 Tm [(common)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.84599304 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.34599304 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.65299988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.15299988 11.72200012 Tm [(mot)1(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.17599487 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.67599487 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.897995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.397995 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.95901489 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(of)1(ten)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.84700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.34700012 27.3220005 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.7159996 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.21600342 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.15699768 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.65699768 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.96399689 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.46399689 27.3220005 Tm [(oligo)1(me)-1(riz)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.24099731 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.74099731 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.01800537 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.51800537 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.07899475 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.57899475 27.3220005 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.26899719 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.76899719 27.3220005 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.70999146 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.47299957 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.97299957 42.92200089 Tm [(suc)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.74000168 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.23999786 42.92200089 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.3809967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.8809967 42.92200089 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.46499634 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.96499634 42.92200089 Tm [(fa)1(c)-1(t)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.75 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.0269928 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.5269928 42.92200089 Tm [(intermediate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.48899841 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.98899841 42.92200089 Tm [(fil)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(aments.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.74599838 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.24599838 58.52199936 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.0530014 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.5530014 58.52199936 Tm [(CCDC47)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.02600098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.52600098 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.04199982 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.54199982 58.52199936 Tm [(map)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.86399841 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.36399841 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.43899536 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.93899536 58.52199936 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.73399353 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.23399353 58.52199936 Tm [(17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.78999329 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.28999329 58.52199936 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.61799622 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.11799622 58.52199936 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(7q23)-1(.3.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.20100021 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.70100021 74.12200165 Tm [(Litt)1(l)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.92200089 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.42200089 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.98300171 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.48300171 74.12200165 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.30200195 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.80200195 74.12200165 Tm [(ab)1(out)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.14500427 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.64500427 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.10099792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.60099792 74.12200165 Tm [(single-pa)1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.91400146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.41400146 74.12200165 Tm [(membrane)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.19799805 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30699921 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80699921 89.72200012 Tm [(exc)-1(ept)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.19599915 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.69599915 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.91799927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.41799927 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.41899872 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.91899872 89.72200012 Tm [(coile)-1(d)1(-c)-1(o)1(il)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.72599792 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.22599792 89.72200012 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.05299377 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.55299377 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.11399841 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.61399841 89.72200012 Tm [(wit)1(hin)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.94999695 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.44999695 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.45100403 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.95100403 89.72200012 Tm [(c)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.75 0.75 m 156.75 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.75 17.10000038 m 156.75 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.75 33.45000076 m 156.75 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.75 49.80000305 m 156.75 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.75 66.15000153 m 156.75 97.3500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.75 98.1000061 m 156.75 113.70000458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.75 114.45000458 m 156.75 130.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 156.75 130.80000305 m 156.75 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.7250061 m 426.17498779 97.7250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.07500458 m 426.17498779 114.07500458 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 130.42500305 m 426.17498779 130.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>