%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 136 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 88 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(TRIM45)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 147.93699646 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 258.37701416 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.37701416 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.68499756 12.82499981 Tm [(TRIM45)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 130.39399719 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 182.89399719 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.14399719 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.31000137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TRIM45)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.81800079 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.19200134 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.96400452 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.33799744 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.65899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.03300476 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.82899475 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(RN)1(F)-1(99)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.9469986 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(TRIM45)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.08399963 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 113.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002000210022000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800220027>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 42.92200089 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 139.42500305 0.75 m 422.42498779 0.75 l 422.42498779 78.75 l 139.42500305 78.75 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(tr)1(i)-1(p)1(art)1(ite)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.82800293 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.32800293 11.72200012 Tm [(mot)1(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.35099792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.85099792 11.72200012 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.09899902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.81399918 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.31399918 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 27.3220005 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.29199982 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.79199982 27.3220005 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.53300476 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.03300476 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.17399597 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.67399597 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64900208 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.14900208 27.3220005 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.10299683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.60299683 27.3220005 Tm [(repre)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ssor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.48999977 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.98999977 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.83200073 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.33200073 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.33300018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.83300018 42.92200089 Tm [(mito)1(gen)-1(-)1(activat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.18899536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.68899536 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.9960022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.4960022 42.92200089 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.58399963 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.08399963 42.92200089 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.71200562 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.21200562 42.92200089 Tm [(Alt)1(e)-1(rn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(at)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.71199989 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.2120018 58.52199936 Tm [(splice)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.29299927 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.79299927 58.52199936 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.71499634 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.21499634 58.52199936 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.78500366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.28500366 58.52199936 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.63200378 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.13200378 58.52199936 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.63900757 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.13900757 58.52199936 Tm [(described.[p)1(rovid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 74.12200165 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.875 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.375 74.12200165 Tm [(RefSeq,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.70100021 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.2009964 74.12200165 Tm [(Mar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.40599823 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 78.75 cm q 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 139.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 95.09999847 cm q 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 139.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(TRIM45)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.02899933 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 111.44999695 cm q 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 139.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(TRIM45)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.375 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 127.80000305 cm q 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 139.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(tr)1(i)-1(p)1(art)1(ite)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.55099869 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.05099869 11.72200012 Tm [(mot)1(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.0739975 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.5739975 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.32099915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.82099915 11.72200012 Tm [(45)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.3769989 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.8769989 11.72200012 Tm [(\(TRIM45)-1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.08500671 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.58500671 11.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.50700378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.00700378 11.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.41099548 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.91101074 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.18899536 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 144.1499939 cm q 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 139.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(RNF99)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.52899933 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 160.5 cm q 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Sw)1(iss)1(P)-1(r)1(o)-1(t:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 46.56900024 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 139.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Q9H)-1(8W5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.28699875 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 176.8500061 cm q 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.47100067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.97100067 11.72200012 Tm [(positive)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.80799866 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.30799866 11.72200012 Tm [(control:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 96.39399719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 139.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.04100037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.54100037 11.72200012 Tm [(ki)-1(d)1(ne)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.00899887 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.50900269 11.72200012 Tm [(tiss)1(u)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.24099731 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 193.19999695 cm q 1 g 0.375 0.75 m 138.67500305 0.75 l 138.67500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 139.67500305 -0.25 l 139.67500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(IH)-1(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.47100067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.97100067 11.72200012 Tm [(Recommend)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.78299713 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.28299713 11.72200012 Tm [(di)1(lution:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 120.1289978 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 139.42500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 139.42500305 16.35000038 l h f* Q q 1 0 0 1 139.05000305 0 cm -0.625 -0.25 m 284.375 -0.25 l 284.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(30)-1(-)1(1)-1(50)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.28300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 209.55001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 0.75 m 139.05000305 78.75 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 79.5 m 139.05000305 95.09999847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 95.84999847 m 139.05000305 111.44999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 112.19999695 m 139.05000305 127.79999542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 128.54998779 m 139.05000305 144.1499939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 144.8999939 m 139.05000305 160.5 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 161.25 m 139.05000305 176.8500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 177.6000061 m 139.05000305 193.20001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.05000305 193.95001221 m 139.05000305 209.55001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 209.55001831 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 79.125 m 422.42498779 79.125 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 95.47499847 m 422.42498779 95.47499847 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 111.82499695 m 422.42498779 111.82499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 128.17498779 m 422.42498779 128.17498779 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 144.5249939 m 422.42498779 144.5249939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 160.875 m 422.42498779 160.875 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 177.2250061 m 422.42498779 177.2250061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 193.57501221 m 422.42498779 193.57501221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.92501831 m 423.17498779 209.92501831 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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