%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 127 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 78.46099854 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 150.2250061 23.67700005 Tm 0 Tr [(TRIM33)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 226.397995 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 336.8380127 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TRIM33)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 132.83399963 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 185.33399963 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.83399963 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TRIM33)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.81800079 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.19200134 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.96400452 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.33799744 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.65899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.03300476 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.82899475 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(triparti)-1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.46199799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.37000275 12.82499981 Tm [(moti)-1(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.42599487 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.33399963 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.16900635 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.07699585 12.82499981 Tm [(33;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.52999878 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.43800354 12.82499981 Tm [(ECT)-1(O;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.04200745 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.94999695 12.82499981 Tm [(PTC7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.2210083 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.1289978 12.82499981 Tm [(RFG7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.41000366 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.31799316 12.82499981 Tm [(TF)-1(1G)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 324.01501465 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 329.92300415 12.82499981 Tm [(TIF)-1(1G)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 357.26501465 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 363.17300415 12.82499981 Tm [(TIF)-1(GA)1(MMA;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29901123 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(TIF)-1(1G)1(AMMA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.63800049 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TRIM33)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.08399963 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.73600006 12.82499981 Tm [(Mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.64700317 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 431.32901001 cm q /GS2 gs 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 141.1499939 l 0.375 141.1499939 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 74.12200165 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 141.1499939 l 140.17500305 141.1499939 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 142.1499939 l -0.625 142.1499939 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(th)1(ought)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.97900391 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.47900391 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.05400085 11.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.90800476 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.40800476 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.38299561 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.88299561 11.72200012 Tm [(tr)1(ansc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ript)1(ional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.96500015 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.46500015 27.3220005 Tm [(corepressor.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.19100189 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.69100189 27.3220005 Tm [(However,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.02000427 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.52000427 27.3220005 Tm [(molec)-1(ules)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.90299988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.40299988 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.625 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.125 27.3220005 Tm [(interact)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.80299377 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.30299377 27.3220005 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.69900513 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.45600033 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.95599937 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.26300049 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.76300049 42.92200089 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.11000061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.61000061 42.92200089 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.23100281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.73100281 42.92200089 Tm [(ye)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.95400238 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.45400238 42.92200089 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.96099854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.46099854 42.92200089 Tm [(identified.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.55799866 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.05799866 42.92200089 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.86500549 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.36500549 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.67199707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.17199707 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.73300171 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.23300171 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.20800781 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.26399994 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.76399994 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.60599899 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.10599899 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.10700226 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.60700226 58.52199936 Tm [(tr)1(i)-1(p)1(art)1(ite)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.15799713 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.65799713 58.52199936 Tm [(mot)1(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.68099976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.18099976 58.52199936 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.42900085 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.92900085 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.19099426 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.69099426 58.52199936 Tm [(mot)1(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.71400452 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.21400452 58.52199936 Tm [(inc)-1(ludes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.63800049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.13800049 58.52199936 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ree)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.64900017 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.14900017 74.12200165 Tm [(zinc-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.06600189 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.56600189 74.12200165 Tm [(do)1(mains,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.72599792 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.22599792 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.2009964 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.70100403 74.12200165 Tm [(RING)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.397995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.897995 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.8730011 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.3730011 74.12200165 Tm [(B-bo)1(x)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.94500732 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.44500732 74.12200165 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.41600037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.91600037 74.12200165 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.19400024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.69400024 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.97099304 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.47099304 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.4460144 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.9460144 74.12200165 Tm [(B-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(bo)1(x)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.03100014 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.53100014 89.72200012 Tm [(type)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.5019989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.0019989 89.72200012 Tm [(2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.44599915 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.94599915 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.22299957 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.72299957 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.69799805 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.19799805 89.72200012 Tm [(coile)-1(d)1(-c)-1(o)1(il)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.00500488 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.50500488 89.72200012 Tm [(region.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.63400269 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.13400269 89.72200012 Tm [(Three)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.48399353 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.98399353 89.72200012 Tm [(alt)1(e)-1(rnat)1(ive)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.50700378 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.00698853 89.72200012 Tm [(splic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 105.3219986 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.28499985 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.78499985 105.3219986 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.35500336 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.85500336 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.13300323 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.63300323 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.08900452 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.58900452 105.3219986 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.10499573 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.60499573 105.3219986 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.95199585 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.45199585 105.3219986 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.95899963 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.45899963 105.3219986 Tm [(described,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.61099243 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.11099243 105.3219986 Tm [(ho)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(wever,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.64599991 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.14599991 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.14699936 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.64699936 120.92199707 Tm [(full-length)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.69499969 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.19499969 120.92199707 Tm [(nature)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.15699768 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.65699768 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.49899292 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.99899292 120.92199707 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.3730011 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.8730011 120.92199707 Tm [(var)1(i)-1(a)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.2769928 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.7769928 120.92199707 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.45899963 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.95899963 120.92199707 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.58000183 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.08000183 120.92199707 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.58700562 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.08700562 120.92199707 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(etermine)-1(d.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.40599823 136.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 141.1499939 cm q /GS2 gs 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(WB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 157.5 cm q /GS2 gs 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TRIM33)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.02899933 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 173.8500061 cm q /GS2 gs 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(TRIM33)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.375 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 190.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 0.75 m 139.80000305 141.1499939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 141.8999939 m 139.80000305 157.5 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 158.25 m 139.80000305 173.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 174.6000061 m 139.80000305 190.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 190.20001221 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 141.5249939 m 422.42498779 141.5249939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 157.875 m 422.42498779 157.875 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 174.2250061 m 422.42498779 174.2250061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 190.57501221 m 423.17498779 190.57501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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