%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 135 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 72 0 cm /P <> BDC BT /FAAABB 18 Tf 1 0 0 -1 0 22.20999908 Tm 2 Tr 0 g 0.51428574 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 18 Tf 1 0 0 -1 58.7159996 22.20999908 Tm 0 Tr [(TRIM29)] TJ ET EMC /P <> BDC BT /FAAABB 18 Tf 1 0 0 -1 121.03900146 22.20999908 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 18 Tf 1 0 0 -1 211.39900208 22.20999908 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(TRIM29)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 122.33399963 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 174.83399963 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.08399963 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TRIM29)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.81800079 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.19200134 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.96400452 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.33799744 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.65899658 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.03300476 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.82899475 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(triparti)-1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.46199799 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.83599854 12.82499981 Tm [(moti)-1(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.89199829 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.26600647 12.82499981 Tm [(con)-1(taini)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.10099792 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.4750061 12.82499981 Tm [(29;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.92799377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.30200195 12.82499981 Tm [(ATDC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.55299377 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TRIM29)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.08399963 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002300240025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 140.17500305 125.55000305 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(belongs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.54499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.04499817 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.11999512 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.61999512 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.1210022 11.72200012 Tm [(TRIM)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.59500122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.09500122 11.72200012 Tm [(pro)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.04699993 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.54700089 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.79499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.29499817 27.3220005 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.29399872 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.79399872 27.3220005 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.47599792 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.97599792 27.3220005 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.34799957 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.84799957 27.3220005 Tm [(zinc)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.727005 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.227005 27.3220005 Tm [(finger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.58799744 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.08799744 27.3220005 Tm [(mot)1(ifs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.2769928 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.7769928 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.05400085 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.55400085 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.52900696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.02900696 27.3220005 Tm [(leu)-1(cine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.63699341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.13699341 27.3220005 Tm [(zi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(pp)1(e)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.03899956 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.53899956 42.92200089 Tm [(mot)1(if.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.72800064 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.22800064 42.92200089 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.22700119 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.72699738 42.92200089 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.40899658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.90899658 42.92200089 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.41600037 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.91600037 42.92200089 Tm [(pro)1(posed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.32099915 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.82099915 42.92200089 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.89599609 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.39599609 42.92200089 Tm [(fo)1(rm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.10699463 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.60699463 42.92200089 Tm [(ho)1(mo-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.91900635 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.41900635 42.92200089 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.57699585 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.07699585 42.92200089 Tm [(hetero)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(dimers)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.29400063 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.79399872 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.89099884 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.39099884 58.52199936 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.90899658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.40899658 58.52199936 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.77799988 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.27799988 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.21899414 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.71899414 58.52199936 Tm [(nuc)-1(leic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.73399353 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.23399353 58.52199936 Tm [(acid)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.87399292 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.37399292 58.52199936 Tm [(binding.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.68400574 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.18400574 58.52199936 Tm [(Thus,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.76300049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.26300049 58.52199936 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.01098633 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.17099953 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.67099953 74.12200165 Tm [(act)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.51200104 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.01200104 74.12200165 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.15299988 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.65299988 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.62799835 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.12799835 74.12200165 Tm [(tr)1(ansc)-1(rip)1(tional)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.08200073 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.58200073 74.12200165 Tm [(regulat)1(ory)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.07200623 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.57200623 74.12200165 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.69099426 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.19099426 74.12200165 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.55999756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.05999756 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.00100708 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.50100708 74.12200165 Tm [(car)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ci)-1(nog)1(e)-1(nesis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.41799927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.91799927 89.72200012 Tm [(and/or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.1989975 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.6989975 89.72200012 Tm [(dif)1(fe)-1(r)1(e)-1(nt)1(i)-1(a)1(tion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.19099426 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.69099426 89.72200012 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.69000244 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.19000244 89.72200012 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.36099243 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.86099243 89.72200012 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.11799622 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.61799622 89.72200012 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.35899353 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.85899353 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.79998779 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.29998779 89.72200012 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 105.3219986 Tm [(supp)1(re)-1(ss)1(i)-1(o)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.35200119 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.85199738 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.69400024 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.19400024 105.3219986 Tm [(rad)1(iosen)-1(s)1(i)-1(t)1(ivity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.84199524 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.34199524 105.3219986 Tm [(sinc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.06900024 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.56900024 105.3219986 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.31700134 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.81700134 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.37800598 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.87800598 105.3219986 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.00500488 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.50500488 105.3219986 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.90100098 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.40100098 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ta)1(xia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.25900078 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.75900078 120.92199707 Tm [(telangiec)-1(t)1(asia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.76899719 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.26899719 120.92199707 Tm [(ph)1(e)-1(not)1(y)-1(p)1(e)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.07000732 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(TRIM29)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.02899933 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(TRIM29)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.375 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 174.6000061 cm q 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(tr)1(i)-1(p)1(art)1(ite)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.55099869 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.05099869 11.72200012 Tm [(mot)1(if)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.0739975 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.5739975 11.72200012 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.32099915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.82099915 11.72200012 Tm [(29)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.3769989 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 190.94999695 cm q 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(ATDC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.36800003 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 207.30003357 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 0.75 m 139.80000305 125.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 126.30000305 m 139.80000305 141.90000916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 142.65000916 m 139.80000305 158.25001526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 159.00001526 m 139.80000305 174.60002136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 175.35002136 m 139.80000305 190.95002747 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 191.70002747 m 139.80000305 207.30003357 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 207.30003357 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 174.97502136 m 422.42498779 174.97502136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 191.32502747 m 422.42498779 191.32502747 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 207.67503357 m 423.17498779 207.67503357 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>