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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 84.68099976 23.67700005 Tm 0 g [(CASP5)] TJ ET EMC /P <</MCID 1 >> BDC BT 1 0 0 -1 142.91400146 23.67700005 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 153.91400146 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 330.61801147 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(CASP5)] TJ ET EMC /P <</MCID 7 >> BDC BT 1 0 0 -1 90.24500275 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 95.49500275 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 179.49499512 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CASP5)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 90.24500275 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 92.6190033 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 125.82099915 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 128.19500732 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 188.17500305 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 190.54899597 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 225.022995 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(caspase)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 75.45300293 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 77.82700348 12.82499981 Tm [(5,)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 85.76899719 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 88.14299774 12.82499981 Tm [(apo)-1(ptos)-1(is-re)1(l)-1(ated)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 163.21699524 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 165.59100342 12.82499981 Tm [(cy)1(s)-1(te)1(i)-1(ne)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 200.78199768 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 203.15600586 12.82499981 Tm [(pepti)-1(dase;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 248.0269928 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 250.40100098 12.82499981 Tm [(ICH-3;)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 276.5329895 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 278.90701294 12.82499981 Tm [(ICERE)-1(L-III;)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 321.48098755 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 323.85501099 12.82499981 Tm [(ICE\()-1(r)1(el\))-1(II)1(I)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 362.82501221 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 48.70299911 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 48.70299911 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 48.70299911 Tm [<0016000F>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 48.70299911 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 42 48.70299911 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 48.70299911 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.35800171 48.70299911 Tm [<0019000A>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 108.35800171 48.70299911 Tm [(  )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 118.85800171 48.70299911 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 216.83399963 m 416.75 216.83399963 l 416.75 248.03399658 l -1.45000005 248.03399658 l h f* Q q 1 0 0 1 0 216.83399963 cm /P <</MCID 55 >> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 275.97299194 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 27.9109993 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 30.28499985 12.55799961 Tm [(protein)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 61.66699982 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 64.04100037 12.55799961 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 125.62599945 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 128 12.55799961 Tm [(to)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 137.05400085 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 139.42799377 12.55799961 Tm [(a)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 144.45799255 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 146.83200073 12.55799961 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 174.1230011 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 176.49699402 12.55799961 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 208.79200745 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 211.16600037 12.55799961 Tm [(from)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 231.95599365 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 234.33000183 12.55799961 Tm [(235-4)1(34)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 269.4750061 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 271.84899902 12.55799961 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 298.73001099 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 301.10400391 12.55799961 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 322.60598755 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 324.98001099 12.55799961 Tm [(of)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 333.7210083 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 336.09500122 12.55799961 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 366.06201172 12.55799961 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 368.43600464 12.55799961 Tm [(CASP5)] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAADC 10 Tf 1 0 0 -1 395.68099976 12.55799961 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q /GS2 gs 1 g -1.45000005 304.9119873 m 416.75 304.9119873 l 416.75 336.11199951 l -1.45000005 336.11199951 l h f* Q q 1 0 0 1 0 304.9119873 cm /P <</MCID 87 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 336.11199951 m 416.75 336.11199951 l 416.75 367.31201172 l -1.45000005 367.31201172 l h f* Q q 1 0 0 1 0 336.11199951 cm /P <</MCID 88 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 89 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <</MCID 90 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 367.31201172 cm /P <</MCID 91 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 395.25100708 cm q /GS2 gs 1 g 0.375 0.75 m 118.77500153 0.75 l 118.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.77500153 -0.25 l 119.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 92 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 95 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.52500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 119.52500153 16.35000038 l h f* Q q 1 0 0 1 119.15000153 0 cm -0.625 -0.25 m 304.2749939 -0.25 l 304.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 96 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(caspa)1(se)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 33.64899826 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 38.14899826 11.72200012 Tm [(5,)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 45.5929985 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 50.0929985 11.72200012 Tm [(ap)1(opt)1(osis-r)1(e)-1(lat)1(e)-1(d)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 126.11000061 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 130.61000061 11.72200012 Tm [(cy)-1(st)1(e)-1(ine)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 165.55999756 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 170.05999756 11.72200012 Tm [(pept)1(idase)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 212.41400146 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 118.77500153 0.75 l 118.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.77500153 -0.25 l 119.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 106 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 107 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.52500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 119.52500153 16.35000038 l h f* Q q 1 0 0 1 119.15000153 0 cm -0.625 -0.25 m 304.2749939 -0.25 l 304.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 108 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ICH-3;)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 26.96500015 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 31.46500015 11.72200012 Tm [(ICERE)1(L)-1(-)1(III;)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 74.51799774 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 79.01799774 11.72200012 Tm [(ICE\(rel\)III)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 117.51799774 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 118.77500153 0.75 l 118.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.77500153 -0.25 l 119.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 114 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 115 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.52500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 119.52500153 16.35000038 l h f* Q q 1 0 0 1 119.15000153 0 cm -0.625 -0.25 m 304.2749939 -0.25 l 304.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 116 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P51)-1(87)-1(8)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 118.77500153 0.75 l 118.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.77500153 -0.25 l 119.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 118 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 121 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.52500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 119.52500153 16.35000038 l h f* Q q 1 0 0 1 119.15000153 0 cm -0.625 -0.25 m 304.2749939 -0.25 l 304.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 122 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC1)-1(13)-1(40)-1(6)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 118.77500153 0.75 l 118.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.77500153 -0.25 l 119.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 124 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 125 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.52500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 119.52500153 16.35000038 l h f* Q q 1 0 0 1 119.15000153 0 cm -0.625 -0.25 m 304.2749939 -0.25 l 304.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 126 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 118.77500153 0.75 l 118.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.77500153 -0.25 l 119.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 142 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 145 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.52500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 119.52500153 16.35000038 l h f* Q q 1 0 0 1 119.15000153 0 cm -0.625 -0.25 m 304.2749939 -0.25 l 304.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 146 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 118.77500153 0.75 l 118.77500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 119.77500153 -0.25 l 119.77500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 150 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 151 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.52500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 119.52500153 16.35000038 l h f* Q q 1 0 0 1 119.15000153 0 cm -0.625 -0.25 m 304.2749939 -0.25 l 304.2749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 152 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 118.77500153 0.75 l 118.77500153 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 119.77500153 -0.25 l 119.77500153 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 164 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 165 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 119.52500153 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 119.52500153 109.94999695 l h f* Q q 1 0 0 1 119.15000153 0 cm -0.625 -0.25 m 304.2749939 -0.25 l 304.2749939 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 166 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(cy)-1(st)1(e)-1(ine-asp)1(art)1(ic)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 242.68099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 247.18099976 11.72200012 Tm [(acid)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 264.8210144 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 269.3210144 11.72200012 Tm [(pro)1(te)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ase)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 14.24699974 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 18.74699974 27.3220005 Tm [(\(caspa)1(se)-1(\))] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 58.40800095 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 62.90800095 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 91.15599823 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 95.65599823 27.3220005 Tm [(Se)-1(q)1(ue)-1(ntia)1(l)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 141.02999878 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 145.52999878 27.3220005 Tm [(activat)1(ion)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 187.47999573 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 191.97999573 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 200.82200623 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 205.32200623 27.3220005 Tm [(caspa)1(se)-1(s)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 243.13699341 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 247.63699341 27.3220005 Tm [(plays)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 269.68399048 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 274.18399048 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 279.15899658 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 283.65899658 27.3220005 Tm [(ce)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ntra)1(l)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 19.70499992 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 24.20499992 42.92200089 Tm [(role)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 40.86500168 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 45.36500168 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 53.30599976 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 57.80599976 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 71.80699921 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 76.30699921 42.92200089 Tm [(exe)-1(cution-p)1(hase)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 147.58599854 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 152.08599854 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 160.92799377 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 165.42799377 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 179.83799744 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 184.33799744 42.92200089 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 228.49899292 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 232.99899292 42.92200089 Tm [(Casp)1(ases)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 272.3210144 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 276.8210144 42.92200089 Tm [(exis)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(t)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 3.35299993 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 7.85300016 58.52199936 Tm [(as)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 16.99399948 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 21.49399948 58.52199936 Tm [(inac)-1(t)1(ive)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 54.50099945 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 59.00099945 58.52199936 Tm [(pro)1(e)-1(nzymes)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 111.45400238 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 115.95400238 58.52199936 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 141.05099487 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 145.55099487 58.52199936 Tm [(undergo)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 182.42100525 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 186.92100525 58.52199936 Tm [(pro)1(teolytic)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 233.42799377 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 237.92799377 58.52199936 Tm [(pro)1(c)-1(essing)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 284.48400879 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 288.98400879 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(t)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 3.35299993 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 7.85300016 74.12200165 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 51.93000031 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 56.43000031 74.12200165 Tm [(asp)1(art)1(i)-1(c)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 89.99099731 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 94.49099731 74.12200165 Tm [(residues)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 130.16999817 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 134.66999817 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 143.74499512 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 148.24499512 74.12200165 Tm [(pro)1(duc)-1(e)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 184.07400513 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 188.57400513 74.12200165 Tm [(tw)1(o)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 204.75500488 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 209.25500488 74.12200165 Tm [(subunits,)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 247.88699341 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 252.38699341 74.12200165 Tm [(larg)1(e)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 274.05599976 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 278.55599976 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 294.83300781 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(small,)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 24.53000069 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 29.03000069 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 46.2519989 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 50.7519989 89.72200012 Tm [(dimerize)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 87.80699921 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 92.30699921 89.72200012 Tm [(to)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 101.38200378 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 105.88200378 89.72200012 Tm [(fo)1(rm)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 126.59300232 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 131.09300232 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 145.09399414 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 149.59399414 89.72200012 Tm [(active)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 174.66000366 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 179.16000366 89.72200012 Tm [(en)-1(z)1(y)-1(me.)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 214.70700073 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 219.20700073 89.72200012 Tm [(Overexpression)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 285.76199341 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 290.26199341 89.72200012 Tm [(o)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(f)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 3.11999989 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 7.61999989 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 21.62100029 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 26.12100029 105.3219986 Tm [(active)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 51.18700027 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 55.68700027 105.3219986 Tm [(fo)1(rm)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 76.39800262 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 80.89800262 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 89.73999786 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 94.23999786 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 109.69599915 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 114.19599915 105.3219986 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 147.57699585 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 152.07699585 105.3219986 Tm [(induc)-1(es)] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 185.10600281 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 189.60600281 105.3219986 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 231.6000061 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 236.1000061 105.3219986 Tm [(in)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 244.04100037 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 248.54100037 105.3219986 Tm [(fib)1(roblas)1(ts.)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 295.93200684 105.3219986 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.15000153 0.75 m 119.15000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.15000153 17.10000038 m 119.15000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.15000153 33.45000076 m 119.15000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.15000153 49.80000305 m 119.15000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.15000153 66.15000153 m 119.15000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.15000153 82.5 m 119.15000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.15000153 98.84999847 m 119.15000153 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 119.15000153 115.19999695 m 119.15000153 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 422.42498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 423.17498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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