%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 133 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 66 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(TRIB)1(3)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 129.88999939 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 240.33000183 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TRIB3)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 124.24700165 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 176.74699402 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.99699402 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TRIB3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.23000336 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.60399628 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.37600708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.75 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.07099915 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.44500732 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.24099731 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(C20orf97;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.09700012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.47100067 12.82499981 Tm [(NI)1(PK;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.58299255 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.95700073 12.82499981 Tm [(SINK)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.46899414 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.84300232 12.82499981 Tm [(SKIP3)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.32400513 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.69799805 12.82499981 Tm [(TRB3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.54899597 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001C001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0020000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TRIB3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.49700165 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0021002200230024000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0027000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130028000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 125.55000305 l 0.375 125.55000305 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 66.3219986 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 66.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 125.55000305 l 141.67500305 125.55000305 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 126.55000305 l -0.625 126.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(put)1(ative)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.84100342 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.34100342 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.647995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.147995 11.72200012 Tm [(ki)-1(na)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.27200031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.77200031 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.99399948 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.49399948 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.05500031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.55500031 27.3220005 Tm [(induc)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.17500305 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.67500305 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.18699646 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.68699646 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.68800354 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.18800354 27.3220005 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.77200317 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.27200317 27.3220005 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.39100647 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.89100647 27.3220005 Tm [(NF-kapp)1(aB)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.04098511 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.54098511 27.3220005 Tm [(Th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 42.92200089 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.11299896 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61299896 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.91999817 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.41999817 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.98100281 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.48100281 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.45600128 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.95600128 42.92200089 Tm [(ne)-1(g)1(ative)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.91799927 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.41799927 42.92200089 Tm [(regulat)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.14500427 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.64500427 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.48699951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.98699951 42.92200089 Tm [(NF-kapp)1(aB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.97099304 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.4710083 42.92200089 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 58.52199936 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.29100037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.79100037 58.52199936 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.04800034 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.54800034 58.52199936 Tm [(sensitize)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.20700073 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.70700073 58.52199936 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.28299713 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.78299713 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.85800171 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.35800171 58.52199936 Tm [(TNF-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.50900269 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.00900269 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.28599548 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.78599548 58.52199936 Tm [(TRAIL-)1(i)-1(nd)1(u)-1(ced)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.93099976 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.43099976 58.52199936 Tm [(ap)1(opt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(osis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.61499977 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.11499977 74.12200165 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.30599976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.80599976 74.12200165 Tm [(ad)1(dition,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.8710022 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.3710022 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.82700348 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.32700348 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.63400269 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.13400269 74.12200165 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.16799927 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.66799927 74.12200165 Tm [(ne)-1(g)1(atively)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.78900146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.28900146 74.12200165 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.96400452 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.46400452 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.46499634 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.96499634 74.12200165 Tm [(ce)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.39499998 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.89499998 89.72200012 Tm [(survival)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.25600052 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.75600052 89.72200012 Tm [(serine)-1(-)1(threonine)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.15799713 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.65799713 89.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.7460022 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.2460022 89.72200012 Tm [(AK)1(T)-1(1.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.89500427 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.39500427 89.72200012 Tm [(Diff)1(e)-1(r)1(e)-1(ntia)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.19900513 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.69900513 89.72200012 Tm [(pro)1(moter)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.65600586 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(usag)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.54999924 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.04999924 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.32699966 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.82699966 105.3219986 Tm [(alt)1(e)-1(rnat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.07299805 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.57299805 105.3219986 Tm [(splicin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.48799896 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.98800659 105.3219986 Tm [(result)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.99099731 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.49099731 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.43200684 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.93200684 105.3219986 Tm [(multiple)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.30400085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.80400085 105.3219986 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.72599792 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.22601318 105.3219986 Tm [(var)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ants)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.20599937 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 125.55000305 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 141.8999939 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(TRIB3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.60499954 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 158.25 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(TRIB3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.95100403 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 174.6000061 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(tr)1(i)-1(b)1(bles)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.34799957 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.84799957 11.72200012 Tm [(pseudokinase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.98100281 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.48100281 11.72200012 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.25900269 11.72200012 Tm [(\(TRIB3)-1(\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.04200745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.54200745 11.72200012 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.46400452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.96400452 11.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.36799622 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.86799622 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.14599609 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 190.94999695 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(C20)-1(or)1(f97)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.57699966 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.07699966 11.72200012 Tm [(NIPK;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.42500305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.92500305 11.72200012 Tm [(SINK;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.96099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.46099854 11.72200012 Tm [(SKIP3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.96399689 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.46400452 11.72200012 Tm [(TRB)-1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.42300415 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 207.30003357 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 0.75 m 141.30000305 125.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 126.30000305 m 141.30000305 141.90000916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 142.65000916 m 141.30000305 158.25001526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 159.00001526 m 141.30000305 174.60002136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 175.35002136 m 141.30000305 190.95002747 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 191.70002747 m 141.30000305 207.30003357 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 207.30003357 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 125.92500305 m 422.42498779 125.92500305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 142.27500916 m 422.42498779 142.27500916 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 158.62501526 m 422.42498779 158.62501526 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 174.97502136 m 422.42498779 174.97502136 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 191.32502747 m 422.42498779 191.32502747 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 207.67503357 m 423.17498779 207.67503357 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>