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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 44 0 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(TRDM)-1(T1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 155.68200684 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 266.12200928 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <</Lang (zh-CN) /MCID 5 >> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 6 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(TRD)-1(M)1(T)-1(1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 125.94400024 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 178.44400024 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 9 >> BDC BT 1 0 0 -1 183.69400024 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 10 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <</MCID 11 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TRDMT1)] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 120.42700195 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 122.8010025 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 151.57299805 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 153.94700623 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 204.26800537 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 206.64199829 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 244.43800354 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 20 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <</MCID 21 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 22 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000C000E>] TJ ET EMC /P <</MCID 23 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tRN)1(A)] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 85.0719986 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 91.70700073 12.82499981 Tm [(asp)-1(ar)1(ti)-1(c)] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 125.41699982 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 132.05200195 12.82499981 Tm [(acid)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 149.44799805 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 156.08299255 12.82499981 Tm [(me)1(th)-1(y)1(l)-1(tr)1(an)-1(sfer)1(ase)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 234.17199707 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 240.80700684 12.82499981 Tm [(1;)] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 248.93800354 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 255.57299805 12.82499981 Tm [(DMNT2;)] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 291.03601074 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 297.67098999 12.82499981 Tm [(DNMT2;)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 333.13400269 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 339.76901245 12.82499981 Tm [(PU)1(MET)-1(;)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 373.96099854 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 380.5960083 12.82499981 Tm [(RN)1(MT)-1(1;)] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 415.29998779 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 0 30.49699783 Tm [(MHSAIIP)] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 37.13499832 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000E>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 59 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000E>] TJ ET EMC /P <</MCID 60 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 66 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000E>] TJ ET EMC /P <</MCID 67 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TRD)-1(M)1(T)-1(1)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 99.69400024 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001F002000210022000E>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mou)-1(se)] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 128.3480072 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <</Lang (zh-CN) /MCID 76 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002300240025000E>] TJ ET EMC /P <</MCID 77 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <</Lang (zh-CN) /MCID 81 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130026000E>] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 400.1289978 m 416.75 400.1289978 l 416.75 431.32901001 l -1.45000005 431.32901001 l h f* Q q 1 0 0 1 0 400.1289978 cm /P <</MCID 87 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 88 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 431.32901001 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 90 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 58.52199936 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 91 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 109.94999695 l 141.67500305 109.94999695 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 92 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(responsib)1(l)-1(e)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 183.01199341 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 187.51199341 11.72200012 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 199.78999329 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 204.28999329 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 218.29100037 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 222.79100037 11.72200012 Tm [(methylat)1(io)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(n)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 5.546 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 10.04599953 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 18.88800049 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 23.38800049 27.3220005 Tm [(asp)1(art)1(i)-1(c)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 56.94900131 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 61.44900131 27.3220005 Tm [(acid)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 79.08899689 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 83.58899689 27.3220005 Tm [(tr)1(ansfer)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 116.72799683 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 121.22799683 27.3220005 Tm [(RNA)1(,)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 142.91900635 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 147.41900635 27.3220005 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 193.90400696 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 198.40400696 27.3220005 Tm [(at)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 206.73199463 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 211.23199463 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 225.23300171 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 229.73300171 27.3220005 Tm [(cy)-1(t)1(osine)-1(-)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(38)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 10.55599976 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 15.05599976 42.92200089 Tm [(residue)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 46.56900024 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 51.06900024 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 59.00999832 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 63.50999832 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 77.51100159 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 82.01100159 42.92200089 Tm [(anticod)1(on)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 125.53900146 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 130.03900146 42.92200089 Tm [(loop)1(.)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 151.79200745 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 156.29200745 42.92200089 Tm [(This)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 173.55400085 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 178.05400085 42.92200089 Tm [(en)-1(z)1(y)-1(me)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 211.43499756 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 215.93499756 42.92200089 Tm [(also)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 233.19200134 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 237.69200134 42.92200089 Tm [(po)1(sse)-1(s)1(s)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(es)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 9.27200031 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 13.77200031 58.52199936 Tm [(residual)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 47.54800034 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 52.04800034 58.52199936 Tm [(DNA)1(-\(cy)-1(t)1(osine)-1(-)1(C5)-1(\))] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 133.21499634 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 137.71499634 58.52199936 Tm [(methyltr)1(ansferase)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 214.69400024 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 219.19400024 58.52199936 Tm [(activit)1(y)-1(.)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 251.83200073 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 256.33200073 58.52199936 Tm [(Wh)1(i)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(le)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 7.50099993 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 12.0010004 74.12200165 Tm [(similar)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 40.19599915 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 44.69599915 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 52.63700104 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 57.13700104 74.12200165 Tm [(seque)-1(nce)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 97.98400116 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 102.48400116 74.12200165 Tm [(and)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 118.76100159 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 123.26100159 74.12200165 Tm [(st)1(ruc)-1(ture)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 161.71800232 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 166.21800232 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 175.29299927 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 179.79299927 74.12200165 Tm [(DNA)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 200.29800415 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 204.79800415 74.12200165 Tm [(cy)-1(t)1(osine)] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 240.36300659 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 244.86300659 74.12200165 Tm [(methy)] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ltra)1(nsferases,)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 56.11399841 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 60.61399841 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 76.06999969 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 80.56999969 89.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 102.08599854 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 106.58599854 89.72200012 Tm [(is)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 113.14700317 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 117.64700317 89.72200012 Tm [(dist)1(in)-1(ct)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 149.125 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 153.625 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 169.9019928 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 174.4019928 89.72200012 Tm [(hig)1(hly)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 200.79600525 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 205.29600525 89.72200012 Tm [(conse)-1(rv)1(e)-1(d)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 249.3730011 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 253.8730011 89.72200012 Tm [(in)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 261.81399536 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 266.31399536 89.72200012 Tm [(it)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(s)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 4.16599989 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 8.66600037 105.3219986 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 44.4070015 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 48.9070015 105.3219986 Tm [(amo)1(n)-1(g)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 79.33899689 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 83.83899689 105.3219986 Tm [(ta)1(xa.)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 103.8690033 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 109.94999695 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 204 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 205 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 206 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 14.80500031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 126.30000305 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 208 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 213 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 214 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(TRDMT1)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 37.12099838 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 142.6499939 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 216 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Immunogen:)] TJ ET EMC /P <</MCID 217 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.89400101 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 218 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Fusion)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 28.15600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 32.65599823 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 63.96300125 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 68.46299744 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 77.30500031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 81.80500031 11.72200012 Tm [(human)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 111.84600067 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 116.34600067 11.72200012 Tm [(TRDMT1)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 153.46699524 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 159 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 228 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 231 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 232 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(tR)1(NA)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 22.87800026 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 27.37800026 11.72200012 Tm [(asp)1(art)1(i)-1(c)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 60.93899918 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 65.43900299 11.72200012 Tm [(acid)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 83.07900238 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 87.57900238 11.72200012 Tm [(methyltr)1(ansferase)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 164.55799866 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 169.05799866 11.72200012 Tm [(1)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 174.33599854 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 175.3500061 cm q 1 g 0.375 0.75 m 140.92500305 0.75 l 140.92500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 141.92500305 -0.25 l 141.92500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 242 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 243 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 141.67500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 141.67500305 16.35000038 l h f* Q q 1 0 0 1 141.30000305 0 cm -0.625 -0.25 m 282.125 -0.25 l 282.125 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 244 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(DMNT2;)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 35.56900024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 40.06900024 11.72200012 Tm [(DNMT2;)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 75.63800049 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 80.13800049 11.72200012 Tm [(PU)1(MET;)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 113.43099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 117.93099976 11.72200012 Tm [(RNMT1)-1(;)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 152.52000427 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 157.02000427 11.72200012 Tm [(MHS)-1(A)1(IIP)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 195.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 191.70001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 0.75 m 141.30000305 109.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 110.69999695 m 141.30000305 126.29999542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 127.04999542 m 141.30000305 142.6499939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 143.3999939 m 141.30000305 159 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 159.75 m 141.30000305 175.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 141.30000305 176.1000061 m 141.30000305 191.70001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 191.70001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 110.32499695 m 422.42498779 110.32499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 126.67499542 m 422.42498779 126.67499542 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 143.0249939 m 422.42498779 143.0249939 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 159.375 m 422.42498779 159.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 175.7250061 m 422.42498779 175.7250061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 192.07501221 m 423.17498779 192.07501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
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