%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 117 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 87.09300232 23.67700005 Tm 0 g [(CARS1)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 151.50300598 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 328.20700073 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CARS1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.02100372 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 85.27100372 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.27099609 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(CARS1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.02100372 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.39499664 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.59700012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.97100067 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.95100403 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.32499695 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.79899597 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [(cy)1(s)-1(te)1(i)-1(nyl-tRNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.91600037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.29000092 12.82499981 Tm [(synthetase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.80200195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.17599487 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.30700684 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.68099976 12.82499981 Tm [(CARS;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.69000244 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.06399536 12.82499981 Tm [(CY)-1(SRS;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.93899536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.31300354 12.82499981 Tm [(MGC:1)1(1246)] TJ ET EMC /P <> BDC BT 1 0 0 -1 285.93099976 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 97.85800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 118.85800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 236.83399963 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 282.71200562 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(1-200)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.85600281 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.89100647 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.93200684 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.96699524 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.39801025 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.43301392 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.92599487 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.96099854 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.64700317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.68200684 12.04500008 Tm [(CARS1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 330.27200317 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 311.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 339.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 385.46798706 cm q /GS2 gs 1 g 0.375 0.75 m 79.375 0.75 l 79.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 80.375 -0.25 l 80.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 80.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 80.125 16.35000038 l h f* Q q 1 0 0 1 79.75 0 cm -0.625 -0.25 m 347.42498779 -0.25 l 347.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(cy)-1(st)1(e)-1(inyl-tR)1(NA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.77299881 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.27300262 11.72200012 Tm [(syntheta)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.34999847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.84999847 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.12799835 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 79.375 0.75 l 79.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 80.375 -0.25 l 80.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 80.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 80.125 16.35000038 l h f* Q q 1 0 0 1 79.75 0 cm -0.625 -0.25 m 347.42498779 -0.25 l 347.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CAR)1(S)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.5890007 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.0890007 11.72200012 Tm [(CY)1(S)-1(R)1(S)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.47200012 11.72200012 Tm [(MGC:)1(1)-1(12)-1(46)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.53399658 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 79.375 0.75 l 79.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 80.375 -0.25 l 80.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 80.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 80.125 16.35000038 l h f* Q q 1 0 0 1 79.75 0 cm -0.625 -0.25 m 347.42498779 -0.25 l 347.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P49)-1(58)-1(9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 79.375 0.75 l 79.375 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 80.375 -0.25 l 80.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 8.40200043 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 80.125 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 80.125 31.95000076 l h f* Q q 1 0 0 1 79.75 0 cm -0.625 -0.25 m 347.42498779 -0.25 l 347.42498779 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(BC0)-1(02)-1(88)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81 cm q /GS2 gs 1 g 0.375 0.75 m 79.375 0.75 l 79.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 80.375 -0.25 l 80.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 80.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 80.125 16.35000038 l h f* Q q 1 0 0 1 79.75 0 cm -0.625 -0.25 m 347.42498779 -0.25 l 347.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 97.34999847 cm q /GS2 gs 1 g 0.375 0.75 m 79.375 0.75 l 79.375 31.95000076 l 0.375 31.95000076 l h f* Q q -0.625 -0.25 m 80.375 -0.25 l 80.375 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(syst)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(em:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 16.64599991 27.3220005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 80.125 0.75 m 426.17498779 0.75 l 426.17498779 31.95000076 l 80.125 31.95000076 l h f* Q q 1 0 0 1 79.75 0 cm -0.625 -0.25 m 347.42498779 -0.25 l 347.42498779 32.95000076 l -0.625 32.95000076 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 19.52199936 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 19.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 19.52199936 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 19.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 129.30000305 cm q /GS2 gs 1 g 0.375 0.75 m 79.375 0.75 l 79.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 80.375 -0.25 l 80.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 80.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 80.125 16.35000038 l h f* Q q 1 0 0 1 79.75 0 cm -0.625 -0.25 m 347.42498779 -0.25 l 347.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 145.6499939 cm q /GS2 gs 1 g 0.375 0.75 m 79.375 0.75 l 79.375 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 80.375 -0.25 l 80.375 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 80.125 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 80.125 78.75 l h f* Q q 1 0 0 1 79.75 0 cm -0.625 -0.25 m 347.42498779 -0.25 l 347.42498779 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.88500214 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.38500214 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.66300201 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.16299438 11.72200012 Tm [(aminoacyl-tR)1(NA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.65100098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.15100098 11.72200012 Tm [(syntheta)1(se)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.39399719 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.89401245 11.72200012 Tm [(cy)-1(st)1(e)-1(inyl-tR)1(NA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 323.66699219 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 328.16699219 11.72200012 Tm [(sy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(nth)1(e)-1(t)1(ase.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.31299973 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.81299973 27.3220005 Tm [(Each)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.79100037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.29100037 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.13300323 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.63300323 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.63400269 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.13400269 27.3220005 Tm [(tw)1(en)-1(t)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.36199951 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.86199951 27.3220005 Tm [(aminoacyl-tR)1(NA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.3500061 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.8500061 27.3220005 Tm [(syntheta)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.09298706 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.59298706 27.3220005 Tm [(cata)1(l)-1(yzes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.26501465 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.76501465 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 320.76599121 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 325.26599121 27.3220005 Tm [(am)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(inoacy)-1(la)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.29899979 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.79899979 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.64099884 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.14099884 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.11599731 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.61599731 42.92200089 Tm [(speci)-1(f)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.57299805 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.07299805 42.92200089 Tm [(tR)1(NA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.95100403 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.45100403 42.92200089 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.60899353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.10899353 42.92200089 Tm [(tR)1(NA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.98699951 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.48699951 42.92200089 Tm [(isoa)1(c)-1(ce)-1(p)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.67599487 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.17599487 42.92200089 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.25799561 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.75799561 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.1539917 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 296.6539917 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.65499878 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.15499878 42.92200089 Tm [(cogn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(at)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.43400002 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.93400002 58.52199936 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.00400162 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.50400162 58.52199936 Tm [(acid.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.30999756 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.80999756 58.52199936 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.0719986 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.5719986 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.08799744 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.58799744 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.14900208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.64900208 58.52199936 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.022995 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.522995 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.36500549 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.86500549 58.52199936 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.77400208 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.27400208 58.52199936 Tm [(located)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.09500122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.59500122 58.52199936 Tm [(ne)-1(a)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.6579895 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.1579895 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.15899658 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.65899658 58.52199936 Tm [(imprinted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 321.82901001 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 326.32901001 58.52199936 Tm [(ge)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.65200043 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.15200043 74.12200165 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.97900009 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.47900009 74.12200165 Tm [(on)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.74700165 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.24700165 74.12200165 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.04199982 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.54200745 74.12200165 Tm [(11)-1(p15.5)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.01199341 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.51199341 74.12200165 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.03300476 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.53300476 74.12200165 Tm [(impor)1(tant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.4940033 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.9940033 74.12200165 Tm [(tumor)1(-supp)1(re)-1(ss)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.61898804 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.11898804 74.12200165 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 336.63500977 74.12200165 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.40000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 79.75 0.75 m 79.75 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 79.75 17.10000038 m 79.75 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 79.75 33.45000076 m 79.75 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 79.75 49.80000305 m 79.75 81 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 79.75 81.75 m 79.75 97.34999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 79.75 98.09999847 m 79.75 129.30000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 79.75 130.05000305 m 79.75 145.65000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 79.75 146.40000916 m 79.75 224.40000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.40000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 81.375 m 426.17498779 81.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 97.72499847 m 426.17498779 97.72499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 129.67500305 m 426.17498779 129.67500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 146.02500916 m 426.17498779 146.02500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.77500916 m 426.92498779 224.77500916 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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