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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm q 1 0 0 1 66 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(TRAPP)-1(C4)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 160.08599854 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 270.52600098 23.67700005 Tm 0 Tr [( )] TJ ET EMC /P <> BDC BT /FAAAAH 22 Tf 1 0 0 -1 281.52600098 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABG 10.5 Tf 1 0 0 -1 292.52600098 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 297.77600098 23.67700005 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 60.56000137 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.68499756 12.82499981 Tm [(TRAP)1(PC4)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 135.97200012 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 188.47200012 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.72200012 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000E000B000C000D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TRA)1(PPC4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.39600372 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.76999664 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.54200745 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.91600037 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.23699951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.61099243 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.40699768 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CGI-104;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.85800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.23200226 12.82499981 Tm [(HS)-1(P)1(C172;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.39599609 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.77000427 12.82499981 Tm [(PTD009;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.54600525 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.91999817 12.82499981 Tm [(SBD)-1(N)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.50300598 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.8769989 12.82499981 Tm [(SY)-1(N)1(BINDIN)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.42401123 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.79800415 12.82499981 Tm [(TRS)-1(23)] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.08401489 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TRAP)1(PC4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.66200256 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002000210022000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800220027>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 105.3219986 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 142.42500305 203.55000305 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(TRAPP)1(C4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.6780014 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.1780014 11.72200012 Tm [(\(tr)1(aff)1(i)-1(cki)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.69400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.19400024 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.50099945 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.00100708 11.72200012 Tm [(pa)1(rticle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.92300415 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.42300415 11.72200012 Tm [(complex)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.9019928 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.4019928 11.72200012 Tm [(4\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.352005 11.72200012 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.60899353 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.10899353 11.72200012 Tm [(kn)-1(o)1(w)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 27.3220005 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.18700027 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.68700027 27.3220005 Tm [(SB)-1(D)1(N,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.86700058 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.36700058 27.3220005 Tm [(TRS2)-1(3,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.31800079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.81800079 27.3220005 Tm [(PTD00)-1(9,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.33899689 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.83900452 27.3220005 Tm [(CGI-)1(1)-1(04,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.09100342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.59100342 27.3220005 Tm [(HS)-1(P)1(C1)-1(72)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.10699463 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.60699463 27.3220005 Tm [(\(hemat)1(opoiet)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.90799999 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.40799999 42.92200089 Tm [(st)1(e)-1(m/pro)1(gen)-1(it)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.53299713 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.03299713 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.44300079 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.94300079 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.25 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.75 42.92200089 Tm [(17)-1(2\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.58900452 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.08900452 42.92200089 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.24699402 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.74699402 42.92200089 Tm [(SYNBINDIN,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.28399658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.78399658 42.92200089 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.34500122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.84500122 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.82000732 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.32000732 42.92200089 Tm [(po)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ts)1(y)-1(nap)1(tic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.81200027 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.31200027 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.6190033 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.1190033 58.52199936 Tm [(belonging)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.09100342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.59100342 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.66600037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.16600037 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.16700745 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.66700745 58.52199936 Tm [(TRAPP)1(C4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.34500122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.84500122 58.52199936 Tm [(subf)1(amily)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.38699341 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.88699341 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.72900391 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.22900391 58.52199936 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 74.12200165 Tm [(TRAPP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.98600006 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.48600006 74.12200165 Tm [(small)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.84999847 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.34999847 74.12200165 Tm [(subunits)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.81600189 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.31600189 74.12200165 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.397995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.897995 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.74000549 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.24000549 74.12200165 Tm [(pro)1(tein)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.8789978 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.3789978 74.12200165 Tm [(Exp)1(re)-1(s)1(se)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.375 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.875 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.81599426 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.31600952 74.12200165 Tm [(ne)-1(u)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(rons)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.87000084 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.37000084 89.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.64699936 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.14699936 89.72200012 Tm [(localizing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.66500092 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.16500092 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.23999786 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.73999786 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.74099731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.24099731 89.72200012 Tm [(Go)1(l)-1(g)1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.20199585 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.70199585 89.72200012 Tm [(ap)1(para)1(tus,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.78999329 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.28999329 89.72200012 Tm [(TRAPP)1(C4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.96800232 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.46800232 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.02900696 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.52900696 89.72200012 Tm [(beli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(eve)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.69400024 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.19400024 105.3219986 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.26900101 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.76900101 105.3219986 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.6230011 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.1230011 105.3219986 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.49199677 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.99199677 105.3219986 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.93299866 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.43299866 105.3219986 Tm [(vesic)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.69000244 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.19000244 105.3219986 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.92500305 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.42500305 105.3219986 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.13600159 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.63600159 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.63699341 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.13699341 105.3219986 Tm [(en)-1(d)1(opla)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(smic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.50699997 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.00699997 120.92199707 Tm [(reticu)-1(lum)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.73100281 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.23100281 120.92199707 Tm [(\(ER\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.06600189 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.56600189 120.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.64099884 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.14099884 120.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.14199829 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.64199829 120.92199707 Tm [(Go)1(l)-1(g)1(i,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.77000427 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.27000427 120.92199707 Tm [(func)-1(t)1(ionin)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.70799255 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.20799255 120.92199707 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.34899902 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.84899902 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.82400513 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.32400513 120.92199707 Tm [(compone)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.89900017 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.39900017 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.24099922 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.74099922 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.74200058 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.24200058 136.52200317 Tm [(multisubunit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.66400146 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.16400146 136.52200317 Tm [(tr)1(anspor)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.89900208 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.39900208 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.70599365 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.20599365 136.52200317 Tm [(pa)1(rticle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.12800598 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.62800598 136.52200317 Tm [(\(TRAP)1(P\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.02000427 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.51998901 136.52200317 Tm [(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(mplex.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.4109993 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.9109993 152.12199402 Tm [(Similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.13499832 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.63500214 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.70999908 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.20999908 152.12199402 Tm [(ot)1(her)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.3690033 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.8690033 152.12199402 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.34199524 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.84199524 152.12199402 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.21099854 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.71099854 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.6519928 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.1519928 152.12199402 Tm [(vesic)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.40899658 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.90899658 152.12199402 Tm [(tr)1(ansp)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(ort)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.51099968 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.01099968 167.72200012 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.16900063 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.66900063 167.72200012 Tm [(synapt)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.12799835 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.62799835 167.72200012 Tm [(func)-1(t)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.53500366 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.03500366 167.72200012 Tm [(TRAPP)1(C4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.71299744 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.21299744 167.72200012 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.42799377 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.92799377 167.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.90299988 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.40299988 167.72200012 Tm [(nonc)-1(la)1(ssic)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.70901489 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.20901489 167.72200012 Tm [(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(DZ)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.43700027 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.93700027 183.32200623 Tm [(do)1(main,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.93099976 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.43099976 183.32200623 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.40599823 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.90599823 183.32200623 Tm [(TRAPP)1(C1)-1(-)1(li)-1(ke)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.27400208 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.77400208 183.32200623 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.60099792 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.10099792 183.32200623 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.37800598 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.87800598 183.32200623 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.85299683 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.35299683 183.32200623 Tm [(C-t)1(e)-1(r)1(min)-1(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.24899292 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.74899292 183.32200623 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.9710083 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.4710083 183.32200623 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 198.92199707 Tm [(similar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.86100006 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.36100006 198.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.43600082 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.93600082 198.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.9109993 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.41100311 198.92199707 Tm [(sho)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.62999725 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.12999725 198.92199707 Tm [(segmen)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.5980072 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.0980072 198.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.94000244 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.44000244 198.92199707 Tm [(RyR.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.1210022 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.6210022 198.92199707 Tm [(Via)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.07699585 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.57699585 198.92199707 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.49099731 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.99099731 198.92199707 Tm [(nonc)-1(la)1(ssic)-1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.29699707 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.79699707 198.92199707 Tm [(PD)] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 0.75 m 142.05000305 203.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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