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g [<000A000B000C000D000E>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TPT1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 120.72899628 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.22900391 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 183.72900391 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TPT1)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 104.71299744 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 107.08699799 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 135.85899353 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 138.23300171 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 188.55400085 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 190.92799377 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 228.72399902 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010001100120013000E>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 26 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <</MCID 27 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 28 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <</MCID 29 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 30 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 31 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 32 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 33 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 34 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <</MCID 35 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 36 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <</MCID 37 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TPT1)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 83.97899628 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 49 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800120026000E>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 348.65100098 m 416.75 348.65100098 l 416.75 379.85101318 l -1.45000005 379.85101318 l h f* Q q 1 0 0 1 0 348.65100098 cm /P <</MCID 66 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 379.85101318 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 69 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 105.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 70 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 146.92500305 203.55000305 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 276.875 -0.25 l 276.875 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 71 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 80 >> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 81 >> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 82 >> BDC BT 1 0 0 -1 150.69900513 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 155.19900513 11.72200012 Tm [(is)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 161.75999451 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 166.25999451 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 171.23500061 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 175.73500061 11.72200012 Tm [(regulat)1(or)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 215.46200562 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 219.96200562 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 228.80400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 233.30400085 11.72200012 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 264.06600952 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 30.91600037 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 35.41600037 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 51.69300079 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 56.19300079 27.3220005 Tm [(pro)1(life)-1(r)1(ation.)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 111.70899963 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 116.20899963 27.3220005 Tm [(Its)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 126.37400055 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 130.87399292 27.3220005 Tm [(mRNA)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 158.83200073 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 163.33200073 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 169.89300537 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 174.39300537 27.3220005 Tm [(hig)1(hly)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 200.78700256 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 205.28700256 27.3220005 Tm [(st)1(ruc)-1(tured)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 249.5 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 254 27.3220005 Tm [(an)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(d)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 5.75699997 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 10.25699997 42.92200089 Tm [(contains)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 46.47200012 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 50.97200012 42.92200089 Tm [(an)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 61.49300003 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 65.99299622 42.92200089 Tm [(oligo)1(pyrimidine)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 133.95899963 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 138.45899963 42.92200089 Tm [(tr)1(ac)-1(t)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 158.08900452 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 162.58900452 42.92200089 Tm [(\(5')-1(-)1(T)-1(OP)1(\))] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 198.07899475 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 202.57899475 42.92200089 Tm [(in)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 210.52000427 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 215.02000427 42.92200089 Tm [(its)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 224.93400574 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 229.43400574 42.92200089 Tm [(5')] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 237.01899719 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 241.51899719 42.92200089 Tm [(untra)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(nslated)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 31.29800034 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 35.79800034 58.52199936 Tm [(region)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 63.75999832 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 68.26000214 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 85.48200226 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 89.98200226 58.52199936 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 129.88900757 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 134.38900757 58.52199936 Tm [(to)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 143.46400452 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 147.96400452 58.52199936 Tm [(repress)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 179.13000488 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 183.63000488 58.52199936 Tm [(its)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 193.54400635 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 198.04400635 58.52199936 Tm [(tr)1(anslatio)1(n)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 243.90499878 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 248.40499878 58.52199936 Tm [(und)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(er)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 8.54300022 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 13.04300022 74.12200165 Tm [(quiesc)-1(ent)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 54.5320015 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 59.0320015 74.12200165 Tm [(conditions.)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 106.31300354 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 110.81300354 74.12200165 Tm [(The)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 126.62000275 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 131.11999512 74.12200165 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 168.6269989 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 173.1269989 74.12200165 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 204.43400574 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 208.93400574 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 215.49499512 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 219.99499512 74.12200165 Tm [(involved)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 256.36401367 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 260.86401367 74.12200165 Tm [(i)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(n)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 5.546 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 10.04599953 89.72200012 Tm [(a)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 15.02099991 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 19.52099991 89.72200012 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 48.27399826 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 52.77399826 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 61.61600113 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 66.11599731 89.72200012 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 96.87799835 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 101.37799835 89.72200012 Tm [(pa)1(thw)1(ays,)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 144.17199707 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 148.67199707 89.72200012 Tm [(inc)-1(luding)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 188.52200317 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 193.02200317 89.72200012 Tm [(ap)1(opt)1(osis,)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 237.18299866 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 241.68299866 89.72200012 Tm [(pro)1(tei)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(n)] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 5.546 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 10.04599953 105.3219986 Tm [(synthesis)] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 49.25 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 53.75 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 70.02700043 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 74.52700043 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 88.93699646 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 93.43699646 105.3219986 Tm [(division.)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 128.70300293 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 133.20300293 105.3219986 Tm [(It)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 139.20199585 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 143.70199585 105.3219986 Tm [(binds)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 167.31399536 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 171.81399536 105.3219986 Tm [(to)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 180.88900757 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 185.38900757 105.3219986 Tm [(and)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 201.66600037 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 206.16600037 105.3219986 Tm [(st)1(abilizes)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 245.29100037 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 249.79100037 105.3219986 Tm [(mic)-1(r)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ot)1(u)-1(b)1(ul)-1(es,)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 39.74900055 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 44.24900055 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 60.52600098 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 65.02600098 120.92199707 Tm [(removal)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 99.81800079 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 104.31800079 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 113.16000366 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 117.66000366 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 133.11599731 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 137.61599731 120.92199707 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 168.92300415 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 173.42300415 120.92199707 Tm [(th)1(rough)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 208.32000732 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 212.82000732 120.92199707 Tm [(ph)1(osph)1(oryla)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(tio)1(n)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 17.01600075 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 21.51600075 136.52200317 Tm [(is)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 28.07699966 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 32.57699966 136.52200317 Tm [(required)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 69.11799622 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 73.61799622 136.52200317 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 85.89600372 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 90.39600372 136.52200317 Tm [(pro)1(gression)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 141.59700012 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 146.09700012 136.52200317 Tm [(th)1(rough)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 180.9940033 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 185.4940033 136.52200317 Tm [(mito)1(tic)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 215.65800476 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 220.15800476 136.52200317 Tm [(and)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 236.43499756 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 240.93499756 136.52200317 Tm [(mei)-1(o)1(ti)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(c)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 4.51300001 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 9.01299953 152.12199402 Tm [(ce)-1(ll)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 23.42300034 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 27.92300034 152.12199402 Tm [(divisions.)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 67.35500336 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 71.85500336 152.12199402 Tm [(This)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 89.11699677 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 93.61699677 152.12199402 Tm [(gene)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 115.13300323 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 119.63300323 152.12199402 Tm [(is)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 126.19400024 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 130.69400024 152.12199402 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 159.51300049 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 164.01300049 152.12199402 Tm [(to)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 173.08799744 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 177.58799744 152.12199402 Tm [(play)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 195.46899414 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 199.96899414 152.12199402 Tm [(a)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 204.94400024 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 209.44400024 152.12199402 Tm [(role)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 226.10400391 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 230.60400391 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 238.54499817 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 243.04499817 152.12199402 Tm [(carci)-1(n)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(og)1(e)-1(nesis,)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 40.13100052 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 44.63100052 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 60.90800095 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 65.40799713 167.72200012 Tm [(is)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 71.96900177 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 76.46900177 167.72200012 Tm [(upregulat)1(e)-1(d)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 129.19500732 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 133.69500732 167.72200012 Tm [(in)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 141.63600159 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 146.13600159 167.72200012 Tm [(some)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 169.56300354 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 174.06300354 167.72200012 Tm [(canc)-1(er)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 202.15299988 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 206.65299988 167.72200012 Tm [(ce)-1(lls.)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 227.39500427 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 231.89500427 167.72200012 Tm [(Alt)1(e)-1(rna)1(t)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(ive)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 12.22599983 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 16.72599983 183.32200623 Tm [(splicin)-1(g)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 49.64099884 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 54.14099884 183.32200623 Tm [(results)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 82.30999756 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 86.80999756 183.32200623 Tm [(in)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 94.75099945 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 99.25099945 183.32200623 Tm [(multiple)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 134.6230011 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 139.1230011 183.32200623 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 180.04499817 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 184.54499817 183.32200623 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 218.11500549 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 222.61500549 183.32200623 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 262.95700073 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 0 198.92199707 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 36.93999863 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 41.43999863 198.92199707 Tm [(isof)1(orms.)] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 80.76699829 198.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 203.55000305 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 295 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 296 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.92500305 16.35000038 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 276.875 -0.25 l 276.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 297 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(ELISA,)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 25.90600014 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 30.40600014 11.72200012 Tm [(WB)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 45.21099854 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 219.8999939 cm q /GS2 gs 1 g 0.375 0.75 m 146.17500305 0.75 l 146.17500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 147.17500305 -0.25 l 147.17500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 301 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Name)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 26.90800095 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 31.40800095 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 40.97000122 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 45.47000122 11.72200012 Tm [(antibod)1(y)-1(:)] TJ ET EMC /P <</MCID 306 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 88.51899719 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 146.92500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 146.92500305 16.35000038 l h f* Q q 1 0 0 1 146.55000305 0 cm -0.625 -0.25 m 276.875 -0.25 l 276.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 307 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(TPT1)] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 21.10300064 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 236.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 0.75 m 146.55000305 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 204.30000305 m 146.55000305 219.90000916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 146.55000305 220.65000916 m 146.55000305 236.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 236.25001526 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 203.92500305 m 422.42498779 203.92500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 220.27500916 m 422.42498779 220.27500916 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 236.62501526 m 423.17498779 236.62501526 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
endobj
6 0 obj
<</Length1 119 0 R/Length 25188>>stream
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