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[<000F>] TJ ET EMC /P <</MCID 26 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<000C>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(CGI-121)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 76.04799652 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0010>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(TPRK)1(B)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 69.40899658 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 41 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011>] TJ ET EMC /P <</MCID 42 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0012>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 113.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001A>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<001B>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 71.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)-1(,)] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 96.61199951 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 98.98600006 12.82499981 Tm [(Mon)-1(k)1(ey)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 133.76699829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002000210022000F>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 74 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0024>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 81 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 88 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800220027>] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 96 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 97 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 98 >> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 187.94999695 l 0.375 187.94999695 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 99 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 97.52200317 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 100 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 143.17500305 187.94999695 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 101 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(CGI-)1(1)-1(21,)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 37.2519989 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 41.7519989 11.72200012 Tm [(also)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 59.00899887 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 63.50899887 11.72200012 Tm [(kn)-1(o)1(wn)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 92.32800293 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 96.82800293 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 105.96900177 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 110.46900177 11.72200012 Tm [(TP53)-1(RK-)1(binding)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 180.31599426 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 184.81599426 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 216.1230011 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 220.6230011 11.72200012 Tm [(and)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 236.8999939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 241.3999939 11.72200012 Tm [(PRP)1(K-)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(binding)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 33.14400101 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 37.64400101 27.3220005 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 71.11699677 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 75.61699677 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 82.1780014 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 86.6780014 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 91.65299988 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 96.15299988 27.3220005 Tm [(17)-1(5)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 111.98600006 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 116.48600006 27.3220005 Tm [(amino)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 143.55599976 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 148.05599976 27.3220005 Tm [(acid)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 165.69599915 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 170.19599915 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 201.50300598 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 206.00300598 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 223.2250061 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 227.7250061 27.3220005 Tm [(is)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 234.28599548 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 238.78599548 27.3220005 Tm [(wid)1(e)-1(ly)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 266.30899048 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(expressed.)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 45.32099915 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 49.82099915 42.92200089 Tm [(Localizing)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 92.56199646 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 97.06199646 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 106.13700104 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 110.63700104 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 124.63800049 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 129.13800049 42.92200089 Tm [(cy)-1(t)1(oplas)1(m)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 173.20599365 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 177.70599365 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 193.98300171 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 198.48300171 42.92200089 Tm [(nuc)-1(leu)-1(s)1(,)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 233.46800232 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 237.96800232 42.92200089 Tm [(CGI-)1(1)-1(2)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(1)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 5.27799988 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 9.77799988 58.52199936 Tm [(interacts)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 46.62200165 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 51.12200165 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 69.51799774 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 74.01799774 58.52199936 Tm [(PRP)1(K,)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 98.78600311 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 103.28600311 58.52199936 Tm [(a)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 108.26100159 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 112.76100159 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 144.06799316 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 148.56799316 58.52199936 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 175.65600586 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 180.15600586 58.52199936 Tm [(th)1(at)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 197.37800598 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 201.87800598 58.52199936 Tm [(ph)1(osph)1(orylates)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 268.26199341 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(Se)-1(r)1(1)-1(5)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 24.29299927 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 28.79299927 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 37.63499832 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 42.13499832 74.12200165 Tm [(p53)-1(.)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 60.60499954 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 65.10500336 74.12200165 Tm [(PRP)1(K)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 87.70600128 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 92.20600128 74.12200165 Tm [(ph)1(osph)1(orylation)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 162.97999573 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 167.47999573 74.12200165 Tm [(of)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 176.32200623 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 180.82200623 74.12200165 Tm [(p53)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 197.12600708 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 201.62600708 74.12200165 Tm [(cause)-1(s)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 230.0980072 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 234.5980072 74.12200165 Tm [(inc)-1(rease)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(d)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 5.75699997 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 10.25699997 89.72200012 Tm [(st)1(abilizat)1(ion)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 62.09899902 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 66.59899902 89.72200012 Tm [(and)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 82.87599945 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 87.37599945 89.72200012 Tm [(activit)1(y)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 117.84799957 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 122.34799957 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 131.19000244 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 135.69000244 89.72200012 Tm [(p53)-1(.)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 154.16000366 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 158.66000366 89.72200012 Tm [(CGI-)1(1)-1(21)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 193.7460022 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 198.2460022 89.72200012 Tm [(may)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 216.41700745 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 220.91700745 89.72200012 Tm [(act)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 233.75799561 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 238.25799561 89.72200012 Tm [(as)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 247.39900208 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 251.89900208 89.72200012 Tm [(an)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 262.42001343 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 266.92001343 89.72200012 Tm [(i)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(nhibit)1(or)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 34.13700104 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 38.63700104 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 47.47900009 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 51.97900009 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 65.98000336 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 70.48000336 105.3219986 Tm [(PRP)1(K-p53)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 113.27799988 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 117.77799988 105.3219986 Tm [(interaction,)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 166.28500366 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 170.78500366 105.3219986 Tm [(th)1(us)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 189.39100647 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 193.89100647 105.3219986 Tm [(preventing)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 240.60899353 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 245.10899353 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 259.10998535 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 263.60998535 105.3219986 Tm [(p)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ho)1(spho)1(ry)-1(la)1(tion)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 65.02600098 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 69.52600098 120.92199707 Tm [(of)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 78.36799622 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 82.86799622 120.92199707 Tm [(p53)-1(.)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 101.33799744 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 105.83799744 120.92199707 Tm [(The)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 121.64499664 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 126.14499664 120.92199707 Tm [(gene)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 147.66099548 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 152.16099548 120.92199707 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 192.50300598 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 197.00300598 120.92199707 Tm [(CGI-)1(1)-1(21)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 232.08900452 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 236.58900452 120.92199707 Tm [(map)1(s)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 259.91101074 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 264.41101074 120.92199707 Tm [(t)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(o)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 5.72200012 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 10.22200012 136.52200317 Tm [(human)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 40.26300049 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 44.76300049 136.52200317 Tm [(chromos)1(ome)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 101.55799866 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 106.05799866 136.52200317 Tm [(2,)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 113.5019989 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 118.0019989 136.52200317 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 143.09899902 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 147.59899902 136.52200317 Tm [(ho)1(u)-1(ses)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 177.84700012 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 182.34700012 136.52200317 Tm [(over)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 201.33599854 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 205.83599854 136.52200317 Tm [(1,4)-1(00)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 229.11399841 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 233.61399841 136.52200317 Tm [(gene)-1(s)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 259.29598999 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 263.79598999 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(nd)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 11.30300045 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 15.80300045 152.12199402 Tm [(comprises)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 59.48899841 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 63.98899841 152.12199402 Tm [(ne)-1(a)1(rly)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 90.21099854 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 94.71099854 152.12199402 Tm [(8%)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 107.9960022 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 112.4960022 152.12199402 Tm [(of)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 121.33799744 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 125.83799744 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 139.83900452 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 144.33900452 152.12199402 Tm [(human)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 174.38000488 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 178.88000488 152.12199402 Tm [(genome.)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 216.71699524 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 221.21699524 152.12199402 Tm [(There)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 245.56700134 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 250.06700134 152.12199402 Tm [(are)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 263.58499146 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 268.08499146 152.12199402 Tm [(t)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(hree)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 19.19099998 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 23.69099998 167.72200012 Tm [(isof)1(orms)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 60.85100174 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 65.35099792 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 74.19300079 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 78.69300079 167.72200012 Tm [(CGI-)1(1)-1(21)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 113.77899933 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 118.27899933 167.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 135.50100708 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 140.00100708 167.72200012 Tm [(are)] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 153.51899719 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 158.01899719 167.72200012 Tm [(pro)1(duc)-1(ed)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 199.60400391 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 204.10400391 167.72200012 Tm [(as)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 213.24499512 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 217.74499512 167.72200012 Tm [(a)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 222.72000122 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 227.22000122 167.72200012 Tm [(result)] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 251.2230072 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 255.7230072 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 264.56500244 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(alt)1(e)-1(rnat)1(ive)] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 45.36500168 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 49.86500168 183.32200623 Tm [(splicin)-1(g)] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 82.77999878 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 87.27999878 183.32200623 Tm [(eve)-1(nt)1(s.)] TJ ET EMC /P <</MCID 312 >> BDC BT 1 0 0 -1 117.44799805 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 187.94999695 cm q 1 g 0.375 0.75 m 142.42500305 0.75 l 142.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 143.42500305 -0.25 l 143.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 313 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 314 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 143.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 143.17500305 16.35000038 l h f* Q q 1 0 0 1 142.80000305 0 cm -0.625 -0.25 m 280.625 -0.25 l 280.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 315 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <</MCID 316 >> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 317 >> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC,)] TJ ET EMC /P <</MCID 318 >> BDC BT 1 0 0 -1 39.26499939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 319 >> BDC BT 1 0 0 -1 43.76499939 11.72200012 Tm [(IF,)] TJ ET EMC /P <</MCID 320 >> BDC BT 1 0 0 -1 53.35800171 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 321 >> BDC BT 1 0 0 -1 57.85800171 11.72200012 Tm [(FC)] TJ ET EMC /P <</MCID 322 >> BDC BT 1 0 0 -1 68.66000366 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 0.75 m 142.80000305 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.80000305 188.69999695 m 142.80000305 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 188.32499695 m 422.42498779 188.32499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 204.67500305 m 423.17498779 204.67500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
endobj
6 0 obj
<</Length1 129 0 R/Length 27576>>stream
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