%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 111 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 74.08899689 23.67700005 Tm 0 g [(CAMKK1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.5059967 23.67700005 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 164.5059967 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 341.20999146 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(CAMK)1(K1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.63300323 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 99.88300323 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 183.88299561 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(CAMK)1(K1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.63300323 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.00700378 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.20899963 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.58299255 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.56300354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.93699646 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.41099548 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(calci)-1(um/calmo)-1(dul)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.86199951 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.23599243 12.82499981 Tm [(depend)-1(e)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.00900269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.38299561 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.76499939 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.13900757 12.82499981 Tm [(kinas)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.19900513 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.57299805 12.82499981 Tm [(kinas)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.63299561 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 291.00698853 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.13800049 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.51199341 12.82499981 Tm [(CAMK)1(KA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 339.14898682 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 226.83399963 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 272.71200562 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(321-5)1(20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(CAMK)1(K1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 347.42001343 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 301.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 329.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 357.5289917 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 385.46798706 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.125 16.35000038 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.42498779 -0.25 l 319.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(calc)-1(ium/c)-1(almo)1(duli)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.29199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.79199982 11.72200012 Tm [(dependen)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.81799316 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.31799316 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.625 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.125 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.21299744 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.71299744 11.72200012 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.80099487 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.30099487 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.57899475 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.125 16.35000038 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.42498779 -0.25 l 319.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CAMK)1(KA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.90499878 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.125 16.35000038 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.42498779 -0.25 l 319.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8N5)-1(S9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.67900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.125 16.35000038 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.42498779 -0.25 l 319.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(31)-1(64)-1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.125 16.35000038 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.42498779 -0.25 l 319.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.125 16.35000038 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.42498779 -0.25 l 319.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 108.125 16.35000038 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.42498779 -0.25 l 319.42498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 107.375 0.75 l 107.375 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 108.375 -0.25 l 108.375 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 108.125 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 108.125 78.75 l h f* Q q 1 0 0 1 107.75 0 cm -0.625 -0.25 m 319.42498779 -0.25 l 319.42498779 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(duc)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.38199997 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.88199997 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.72399902 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.22399902 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.68000031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.18000031 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.69599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.19599915 11.72200012 Tm [(belongs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.63600159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.13600159 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.21099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.71099854 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.71200562 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.21200562 11.72200012 Tm [(Se)-1(r)1(in)-1(e/T)-1(h)1(re)-1(o)1(ni)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.3999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.8999939 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.20700073 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.70700073 11.72200012 Tm [(ki)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(nase)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.79299927 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.29299927 27.3220005 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.54100037 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.04100037 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.31800079 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.81800079 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.89299774 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.39299774 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.39399719 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.89399719 27.3220005 Tm [(Ca\(2+\)/calmodulin-dependen)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.29499817 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.79499817 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.10198975 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.60198975 27.3220005 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.69000244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(subf)1(amily)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.70800018 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.20800018 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.47000122 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.97000122 42.92200089 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.27700043 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.77700043 42.92200089 Tm [(plays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.8239975 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.32400513 42.92200089 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.29899597 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.79899597 42.92200089 Tm [(role)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.45899963 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.95899963 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.8999939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.3999939 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.40100098 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.90100098 42.92200089 Tm [(calc)-1(ium/c)-1(almo)1(duli)-1(n-)1(depen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(dent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.76199913 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.26199913 58.52199936 Tm [(\(CaM\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 50.06200027 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.56200027 58.52199936 Tm [(ki)-1(na)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.65000153 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.15000153 58.52199936 Tm [(casc)-1(a)1(de.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.32099915 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.82099915 58.52199936 Tm [(Three)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.17100525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.67100525 58.52199936 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.59300232 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.09300232 58.52199936 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.66299438 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.16299438 58.52199936 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.50500488 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.00500488 58.52199936 Tm [(tw)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.18600464 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.68600464 58.52199936 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(istinct)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.72100067 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.22100067 74.12200165 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.3809967 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.8809967 74.12200165 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.22799683 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.72799683 74.12200165 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.23500061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.73500061 74.12200165 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.66600037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.16600037 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.44400024 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.94400024 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.3999939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.8999939 74.12200165 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.58200073 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 0.75 m 107.75 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 17.10000038 m 107.75 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 33.45000076 m 107.75 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 49.80000305 m 107.75 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 66.15000153 m 107.75 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 82.5 m 107.75 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 98.84999847 m 107.75 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.75 115.19999695 m 107.75 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92498779 193.57499695 l S Q Q q 1 0 0 1 0 579.41802979 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 607.35699463 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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