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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 77.27999878 23.67700005 Tm 0 g [(CALHM1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 1 >> BDC BT /FAAABE 22 Tf 1 0 0 -1 161.31599426 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <</MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 338.01998901 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 3 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <</MCID 4 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 5 >> BDC BT 1 0 0 -1 63 12.82499981 Tm [(CALHM1)] TJ ET EMC /P <</MCID 6 >> BDC BT 1 0 0 -1 99.92900085 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 7 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 105.17900085 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <</MCID 8 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 189.17900085 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 9 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <</MCID 10 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 11 >> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(CALHM1)] TJ ET EMC /P <</MCID 12 >> BDC BT 1 0 0 -1 94.67900085 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 97.0530014 12.82499981 Tm [(Antigen)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 130.25500488 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 132.6289978 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 192.60899353 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 194.98300171 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 229.45700073 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 19 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <</MCID 20 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(   )] TJ ET EMC /P <</MCID 23 >> BDC BT 1 0 0 -1 57.75 12.82499981 Tm [(calci)-1(um)] TJ ET EMC /P <</MCID 24 >> BDC BT 1 0 0 -1 90.38300323 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 92.75700378 12.82499981 Tm [(ho)-1(me)1(os)-1(tasis)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 146.23599243 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 148.61000061 12.82499981 Tm [(mod)-1(ulato)-1(r)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 193.72200012 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 196.09599304 12.82499981 Tm [(1;)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 204.227005 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 206.60099792 12.82499981 Tm [(FAM26C)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 242.72000122 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 37 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 57.75 12.82499981 Tm [<001400150005>] TJ ET EMC /P <</MCID 38 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 89.25 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 39 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 103.10800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <</MCID 40 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 124.10800171 12.82499981 Tm [(  )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 236.83399963 cm /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 50 >> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 282.71200562 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <</MCID 51 >> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 55 >> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <</MCID 56 >> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 57 >> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <</MCID 58 >> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(147-3)1(46)] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <</MCID 70 >> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <</MCID 74 >> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(CALHM1)] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 347.45999146 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 311.65100098 cm /P <</MCID 79 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 339.58999634 cm /P <</Lang (zh-CN) /MCID 80 >> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <</MCID 81 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 367.5289917 cm /P <</MCID 82 >> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 395.46798706 cm q /GS2 gs 1 g 0.375 0.75 m 103.57499695 0.75 l 103.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 104.57499695 -0.25 l 104.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 83 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <</MCID 86 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 104.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 104.32499695 16.35000038 l h f* Q q 1 0 0 1 103.94999695 0 cm -0.625 -0.25 m 323.2250061 -0.25 l 323.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 87 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(calc)-1(ium)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 32.77000046 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 37.27000046 11.72200012 Tm [(ho)1(me)-1(os)1(tasis)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 91.01499939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 95.51499939 11.72200012 Tm [(mod)1(u)-1(la)1(tor)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 140.85299683 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 145.35299683 11.72200012 Tm [(1)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 150.6309967 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 103.57499695 0.75 l 103.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 104.57499695 -0.25 l 104.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 95 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <</MCID 96 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 104.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 104.32499695 16.35000038 l h f* Q q 1 0 0 1 103.94999695 0 cm -0.625 -0.25 m 323.2250061 -0.25 l 323.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 97 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(FAM26)-1(C)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 36.48300171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 103.57499695 0.75 l 103.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 104.57499695 -0.25 l 104.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 99 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <</MCID 100 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 104.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 104.32499695 16.35000038 l h f* Q q 1 0 0 1 103.94999695 0 cm -0.625 -0.25 m 323.2250061 -0.25 l 323.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 101 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8IU99)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 32.53300095 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 103.57499695 0.75 l 103.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 104.57499695 -0.25 l 104.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 103 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <</MCID 106 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 104.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 104.32499695 16.35000038 l h f* Q q 1 0 0 1 103.94999695 0 cm -0.625 -0.25 m 323.2250061 -0.25 l 323.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 107 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(36)-1(19)-1(3)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 103.57499695 0.75 l 103.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 104.57499695 -0.25 l 104.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 109 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <</MCID 110 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 104.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 104.32499695 16.35000038 l h f* Q q 1 0 0 1 103.94999695 0 cm -0.625 -0.25 m 323.2250061 -0.25 l 323.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 111 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 103.57499695 0.75 l 103.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 104.57499695 -0.25 l 104.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 127 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <</MCID 130 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 104.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 104.32499695 16.35000038 l h f* Q q 1 0 0 1 103.94999695 0 cm -0.625 -0.25 m 323.2250061 -0.25 l 323.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 131 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 103.57499695 0.75 l 103.57499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 104.57499695 -0.25 l 104.57499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 135 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <</MCID 136 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 104.32499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 104.32499695 16.35000038 l h f* Q q 1 0 0 1 103.94999695 0 cm -0.625 -0.25 m 323.2250061 -0.25 l 323.2250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 137 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 103.57499695 0.75 l 103.57499695 78.75 l 0.375 78.75 l h f* Q q -0.625 -0.25 m 104.57499695 -0.25 l 104.57499695 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 149 >> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 42.92200089 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 150 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 42.92200089 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 104.32499695 0.75 m 426.17498779 0.75 l 426.17498779 78.75 l 104.32499695 78.75 l h f* Q q 1 0 0 1 103.94999695 0 cm -0.625 -0.25 m 323.2250061 -0.25 l 323.2250061 79.75 l -0.625 79.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 151 >> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(calc)-1(ium)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 130.44000244 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 134.94000244 11.72200012 Tm [(channe)-1(l)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 168.56300354 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 173.06300354 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 190.28500366 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 194.78500366 11.72200012 Tm [(plays)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 216.83200073 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 221.33200073 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 226.30700684 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 230.80700684 11.72200012 Tm [(role)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 247.46699524 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 251.96699524 11.72200012 Tm [(in)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 259.9079895 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 264.4079895 11.72200012 Tm [(pro)1(c)-1(essing)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 310.96398926 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 8.84200001 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 13.34200001 27.3220005 Tm [(amyloid-)1(beta)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 70.85800171 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 75.35800171 27.3220005 Tm [(precu)-1(r)1(sor)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 116.46900177 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 120.96900177 27.3220005 Tm [(pro)1(tein)-1(.)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 154.44200134 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 158.94200134 27.3220005 Tm [(A)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 165.2749939 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 169.7749939 27.3220005 Tm [(po)1(l)-1(ymor)1(phism)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 232.27799988 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 236.77799988 27.3220005 Tm [(at)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 245.10600281 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 249.60600281 27.3220005 Tm [(th)1(is)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 265.06201172 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 269.56201172 27.3220005 Tm [(locu)-1(s)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 291.9039917 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 296.4039917 27.3220005 Tm [(ha)1(s)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 311.08599854 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(been)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 21.50699997 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 26.00699997 42.92200089 Tm [(repor)1(ted)] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 63.67300034 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 68.17299652 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 77.2480011 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 81.7480011 42.92200089 Tm [(be)] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 92.60199738 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 97.10199738 42.92200089 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 142.22900391 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 146.72900391 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 165.125 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 169.625 42.92200089 Tm [(susce)-1(pt)1(ibility)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 225.66799927 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 230.16799927 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 239.24299622 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 243.74299622 42.92200089 Tm [(lat)1(e)-1(-)1(onse)-1(t)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 287.35900879 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 291.85900879 42.92200089 Tm [(Alz)1(h)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(eim)-1(er's)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 30.95100021 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 35.45100021 58.52199936 Tm [(disease)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 67.12200165 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 71.62200165 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 79.56300354 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 84.06300354 58.52199936 Tm [(some)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 107.48999786 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 111.98999786 58.52199936 Tm [(po)1(pulations,)] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 165.47099304 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 169.97099304 58.52199936 Tm [(but)] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 184.61799622 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 189.11799622 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 203.1190033 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 207.6190033 58.52199936 Tm [(pa)1(tho)1(gen)-1(icity)] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 266.7869873 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 271.2869873 58.52199936 Tm [(of)] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 280.1289978 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 284.6289978 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 300.08499146 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 304.58499146 58.52199936 Tm [(p)] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(olymorp)1(hism)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 56.75500107 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 61.25500107 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 67.81600189 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 72.31600189 74.12200165 Tm [(unc)-1(lear.)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 106 74.12200165 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.94999695 0.75 m 103.94999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.94999695 17.10000038 m 103.94999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.94999695 33.45000076 m 103.94999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.94999695 49.80000305 m 103.94999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.94999695 66.15000153 m 103.94999695 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.94999695 82.5 m 103.94999695 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.94999695 98.84999847 m 103.94999695 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 103.94999695 115.19999695 m 103.94999695 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 193.19999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 193.57499695 m 426.92498779 193.57499695 l S Q Q q 1 0 0 1 0 589.41802979 cm /P <</MCID 241 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q Q 1 0 0 -1 0 841.90002441 cm 
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