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228.92900085 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 27 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F>] TJ ET EMC /P <</MCID 28 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 29 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<000C>] TJ ET EMC /P <</MCID 30 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(P7)1(3)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 58.06800079 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 37 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0010>] TJ ET EMC /P <</MCID 38 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(TP73)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 63.18500137 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 43 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011>] TJ ET EMC /P <</MCID 44 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 45 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<0012>] TJ ET EMC /P <</MCID 46 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 47 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 48 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [<001300140015>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 51 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 87.35800171 12.82499981 Tm [<00160017>] TJ ET EMC /P <</MCID 52 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 53 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 113.60800171 12.82499981 Tm [<00180019>] TJ ET EMC /P <</MCID 54 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001A>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(   )] TJ ET EMC /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [<001B>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 39.56000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 41.93399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 61 >> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 62 >> BDC BT 1 0 0 -1 71.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 64 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C001D001E001F>] TJ ET EMC /P <</MCID 65 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 67 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 68 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 69 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 70 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002000210022000F>] TJ ET EMC /P <</MCID 71 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 74 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00230005>] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0024>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0025>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 81 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0026>] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 88 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800220027>] TJ ET EMC /P <</MCID 89 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [(:)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 44.81000137 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 47.18399811 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 96 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 97 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 98 >> BDC BT /FAAACJ 18 Tf 1 0 0 -1 42 20.17499924 Tm 1 Tr 0.51428574 w /GS3 gs 0 G [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 187.94999695 l 0.375 187.94999695 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 99 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 97.52200317 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 100 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 57.29199982 97.52200317 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 187.94999695 l 140.17500305 187.94999695 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 188.94999695 l -0.625 188.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 101 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 165.7769928 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 170.2769928 11.72200012 Tm [(p53)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 186.58099365 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 191.08099365 11.72200012 Tm [(fa)1(mi)-1(ly)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 217.16299438 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 221.66299438 11.72200012 Tm [(of)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 230.50500488 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 235.00500488 11.72200012 Tm [(tr)1(ansc)-1(rip)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(tio)1(n)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 17.01600075 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 21.51600075 27.3220005 Tm [(fa)1(c)-1(t)1(ors)] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 50.80099869 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 55.30099869 27.3220005 Tm [(involved)] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 91.66999817 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 96.16999817 27.3220005 Tm [(in)] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 104.11100006 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 108.61100006 27.3220005 Tm [(ce)-1(llular)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 139.3730011 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 143.8730011 27.3220005 Tm [(responses)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 187.03599548 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 191.53599548 27.3220005 Tm [(to)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 200.61099243 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 205.11099243 27.3220005 Tm [(st)1(re)-1(ss)] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 229.50500488 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 234.00500488 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 250.28199768 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 254.78199768 27.3220005 Tm [(deve)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(lopment.)] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 38.47000122 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 42.97000122 42.92200089 Tm [(It)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 48.96900177 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 53.46900177 42.92200089 Tm [(map)1(s)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 76.79100037 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 81.29100037 42.92200089 Tm [(to)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 90.36599731 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 94.86599731 42.92200089 Tm [(a)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 99.84100342 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 104.34100342 42.92200089 Tm [(region)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 132.30299377 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 136.80299377 42.92200089 Tm [(on)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 148.07099915 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 152.57099915 42.92200089 Tm [(chromos)1(ome)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 209.36599731 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 213.86599731 42.92200089 Tm [(1p3)-1(6)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 235.44799805 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 239.94799805 42.92200089 Tm [(th)1(at)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 257.17001343 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 261.67001343 42.92200089 Tm [(is)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 268.23098755 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(frequently)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 44.13000107 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 48.63000107 58.52199936 Tm [(dele)-1(t)1(ed)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 81.21099854 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 85.71099854 58.52199936 Tm [(in)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 93.65200043 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 98.15200043 58.52199936 Tm [(ne)-1(uro)1(blast)1(oma)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 163.2749939 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 167.7749939 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 184.05200195 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 188.55200195 58.52199936 Tm [(ot)1(her)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 211.71099854 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 216.21099854 58.52199936 Tm [(tumor)1(s,)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 249.03399658 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 253.53399658 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 269.81100464 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(th)1(ought)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 34.81299973 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 39.31299973 74.12200165 Tm [(to)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 48.38800049 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 52.88800049 74.12200165 Tm [(contain)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 84.93699646 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 89.43699646 74.12200165 Tm [(multiple)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 124.80899811 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 129.30900574 74.12200165 Tm [(tumor)] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 155.79899597 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 160.29899597 74.12200165 Tm [(supp)1(re)-1(ss)1(or)] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 207.53999329 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 212.03999329 74.12200165 Tm [(gene)-1(s.)] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 239.88800049 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 244.38800049 74.12200165 Tm [(The)] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 260.19500732 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 264.69500732 74.12200165 Tm [(d)] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(emonstra)1(tion)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 57.75299835 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 62.25299835 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 79.47499847 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 83.97499847 89.72200012 Tm [(th)1(is)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 99.43099976 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 103.93099976 89.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 125.4469986 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 129.94700623 89.72200012 Tm [(is)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 136.50799561 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 141.00799561 89.72200012 Tm [(monoa)1(l)-1(lelic)-1(a)1(l)-1(ly)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 205.13299561 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 209.63299561 89.72200012 Tm [(expressed)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 252.78700256 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 257.2869873 89.72200012 Tm [(\(lik)-1(e)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ly)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 7.15899992 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 11.6590004 105.3219986 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 32.36999893 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 36.86999893 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 50.87099838 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 55.37099838 105.3219986 Tm [(mat)1(e)-1(rna)1(l)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 93.58999634 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 98.08999634 105.3219986 Tm [(allele)-1(\),)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 125.63500214 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 130.13499451 105.3219986 Tm [(supp)1(orts)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 168.02000427 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 172.52000427 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 186.52099609 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 191.02099609 105.3219986 Tm [(notio)1(n)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 219.30400085 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 223.80400085 105.3219986 Tm [(th)1(at)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 241.02600098 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 245.52600098 105.3219986 Tm [(it)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 251.27400208 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 255.77400208 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 262.33499146 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 266.83499146 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 271.80999756 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(candidat)1(e)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 42.37599945 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 46.87599945 120.92199707 Tm [(gene)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 68.39199829 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 72.89199829 120.92199707 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 85.16999817 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 89.66999817 120.92199707 Tm [(ne)-1(uro)1(blast)1(oma.)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 156.95899963 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 161.45899963 120.92199707 Tm [(Many)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 185.53700256 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 190.03700256 120.92199707 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 230.95899963 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 235.45899963 120.92199707 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 269.0289917 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(resulting)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 37.70100021 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 42.20100021 136.52200317 Tm [(fro)1(m)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 62.91199875 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 67.41200256 136.52200317 Tm [(alt)1(e)-1(rnat)1(ive)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 112.77700043 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 117.27700043 136.52200317 Tm [(splicin)-1(g)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 150.19200134 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 154.69200134 136.52200317 Tm [(and/or)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 183.9730072 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 188.4730072 136.52200317 Tm [(use)] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 203.29100037 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 207.79100037 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 216.63299561 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 221.13299561 136.52200317 Tm [(alt)1(e)-1(rnat)1(e)] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 259.3789978 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 263.8789978 136.52200317 Tm [(pr)] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(omo)1(ters)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 35.93799973 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 40.43799973 152.12199402 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 60.78499985 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 65.28500366 152.12199402 Tm [(been)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 86.79199982 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 91.29199982 152.12199402 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 116.98200226 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 121.48200226 152.12199402 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 133.75999451 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 138.25999451 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 153.71600342 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 158.21600342 152.12199402 Tm [(gene)-1(,)] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 181.897995 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 186.397995 152.12199402 Tm [(but)] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 201.04499817 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 205.54499817 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 219.54600525 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 224.04600525 152.12199402 Tm [(biolo)1(gic)-1(a)1(l)] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 266.06201172 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 270.56201172 152.12199402 Tm [(v)] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(alidit)1(y)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 26.03300095 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 30.53300095 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 46.81000137 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 51.31000137 167.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 65.31099701 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 69.81099701 167.72200012 Tm [(full-length)] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 114.85900116 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 119.35900116 167.72200012 Tm [(nature)] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 147.32099915 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 151.82099915 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 160.66299438 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 165.16299438 167.72200012 Tm [(some)] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 188.58999634 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 193.08999634 167.72200012 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 226.66000366 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 231.16000366 167.72200012 Tm [(ha)1(ve)] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 251.50700378 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 256.00698853 167.72200012 Tm [(not)] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 270.62799072 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(been)] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 21.50699997 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 26.00699997 183.32200623 Tm [(determine)-1(d)1(.)] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 78.16999817 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 311 >> BDC BT 1 0 0 -1 82.66999817 183.32200623 Tm [([pr)1(ovided)] TJ ET EMC /P <</MCID 312 >> BDC BT 1 0 0 -1 124.32099915 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 313 >> BDC BT 1 0 0 -1 128.82099915 183.32200623 Tm [(by)] TJ ET EMC /P <</MCID 314 >> BDC BT 1 0 0 -1 139.33299255 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 315 >> BDC BT 1 0 0 -1 143.83299255 183.32200623 Tm [(RefSeq,)] TJ ET EMC /P <</MCID 316 >> BDC BT 1 0 0 -1 176.15899658 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 317 >> BDC BT 1 0 0 -1 180.65899658 183.32200623 Tm [(Fe)-1(b)] TJ ET EMC /P <</MCID 318 >> BDC BT 1 0 0 -1 196.29499817 183.32200623 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 187.94999695 cm q 1 g 0.375 0.75 m 139.42500305 0.75 l 139.42500305 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 140.42500305 -0.25 l 140.42500305 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 319 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <</MCID 320 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 140.17500305 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 140.17500305 16.35000038 l h f* Q q 1 0 0 1 139.80000305 0 cm -0.625 -0.25 m 283.625 -0.25 l 283.625 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 321 >> BDC BT /FAAADF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <</MCID 322 >> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 323 >> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC,)] TJ ET EMC /P <</MCID 324 >> BDC BT 1 0 0 -1 39.26499939 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 325 >> BDC BT 1 0 0 -1 43.76499939 11.72200012 Tm [(IF)] TJ ET EMC /P <</MCID 326 >> BDC BT 1 0 0 -1 51.19200134 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 0.75 m 139.80000305 187.94999695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 139.80000305 188.69999695 m 139.80000305 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 204.30000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 188.32499695 m 422.42498779 188.32499695 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 204.67500305 m 423.17498779 204.67500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
endobj
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