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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 91.34700012 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 163.11099243 23.67700005 Tm 0 Tr [(TP53)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 213.51300049 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 323.95300293 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TP53)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 120.93499756 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 173.43499756 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.18499756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TP5)1(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.91799927 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.29199982 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.06399536 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43800354 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.75900269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.13299561 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.92900085 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tumo)-1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.6190033 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.99299622 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.375 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.74900055 12.82499981 Tm [(p53;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.71899414 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.09300232 12.82499981 Tm [(P5)1(3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.97000122 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.34399414 12.82499981 Tm [(BCC7;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.38400269 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.75799561 12.82499981 Tm [(LF)-1(S1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.95300293 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.32699585 12.82499981 Tm [(TRP53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.21299744 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TP53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.18499756 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q /GS2 gs 1 g 0.375 0.75 m 141.67500305 0.75 l 141.67500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 142.67500305 -0.25 l 142.67500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 105.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 142.42500305 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 142.42500305 203.55000305 l h f* Q q 1 0 0 1 142.05000305 0 cm -0.625 -0.25 m 281.375 -0.25 l 281.375 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.68499756 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.18499756 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.49200439 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.99200439 11.72200012 Tm [(p53)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.46200562 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.96200562 11.72200012 Tm [(wh)1(ic)-1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.05900574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.55900574 11.72200012 Tm [(respond)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.20599365 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.70599365 11.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.78100586 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.28100586 11.72200012 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(iverse)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.93499947 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.43499947 27.3220005 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.1969986 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.6969986 27.3220005 Tm [(st)1(re)-1(ss)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.36399841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.86399841 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.93900299 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.43900299 27.3220005 Tm [(regulat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.11399841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.61399841 27.3220005 Tm [(ta)1(rget)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.59399414 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.09399414 27.3220005 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.77600098 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.27600098 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.4980011 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.9980011 27.3220005 Tm [(induc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 267.86099243 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.40999985 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.90999985 42.92200089 Tm [(cy)-1(cle)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.20199966 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.70199966 42.92200089 Tm [(arr)1(e)-1(st)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.34200287 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.84200287 42.92200089 Tm [(ap)1(opt)1(osis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.00299835 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.50299835 42.92200089 Tm [(sene)-1(sce)-1(nce)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.54499817 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.04499817 42.92200089 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.55000305 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.05000305 42.92200089 Tm [(repair,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.31399536 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.81399536 42.92200089 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.97200012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 250.47200012 42.92200089 Tm [(chan)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ges)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.02900028 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.52899933 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.46999931 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.96999931 58.52199936 Tm [(metab)1(olism.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.86299896 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.36299896 58.52199936 Tm [(p53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.66699982 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.16699982 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.47399902 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.97399902 58.52199936 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.53500366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.03500366 58.52199936 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.18899536 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.68899536 58.52199936 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.01699829 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.51699829 58.52199936 Tm [(low)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.74000549 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.24000549 58.52199936 Tm [(leve)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.9670105 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 261.4670105 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.4079895 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.50699997 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.00699997 74.12200165 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.58300018 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.08300018 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.36000061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.86000061 74.12200165 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.18800354 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.68800354 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.66300201 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.16300201 74.12200165 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.39800262 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.89800262 74.12200165 Tm [(leve)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.625 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.125 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.06599426 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.56599426 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.54100037 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.04100037 74.12200165 Tm [(var)1(i)-1(ety)] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.79400635 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.29400635 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.13600159 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.63600159 74.12200165 Tm [(tr)1(ansfor)1(me)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.68701172 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.40999985 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.90999985 89.72200012 Tm [(line)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.68500137 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.18500137 89.72200012 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.48200226 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.98200226 89.72200012 Tm [(it's)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.20300293 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.70300293 89.72200012 Tm [(belie)-1(ved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.04100037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.54100037 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.61599731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.11599731 89.72200012 Tm [(contribut)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.83500671 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.33500671 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.41000366 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.91000366 89.72200012 Tm [(tr)1(ansfor)1(m)-1(a)1(tio)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.546 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04599953 105.3219986 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.32299995 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.82299995 105.3219986 Tm [(malignancy)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.28700256 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.78700256 105.3219986 Tm [(p53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.09100342 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.59100342 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.15200043 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.65200043 105.3219986 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.6269989 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.1269989 105.3219986 Tm [(DNA)1(-binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.66900635 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.16900635 105.3219986 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.47599792 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.97599792 105.3219986 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.72299194 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(tr)1(ansc)-1(rip)1(tion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.58399963 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.08399963 120.92199707 Tm [(activat)1(ion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.2009964 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.7009964 120.92199707 Tm [(DNA)1(-binding,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.40899658 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.90899658 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.18600464 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.68600464 120.92199707 Tm [(oligo)1(me)-1(riz)1(ation)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.4630127 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.9630127 120.92199707 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(oma)1(i)-1(ns.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.40299988 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.90299988 136.52200317 Tm [(It)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.90200043 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.40200043 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.96300125 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.46300125 136.52200317 Tm [(po)1(stulat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.58399963 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.08399963 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.15899658 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.65899658 136.52200317 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.10499573 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.60499573 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.67999268 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.17999268 136.52200317 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.15499878 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.65499878 136.52200317 Tm [(p53)-1(-)1(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.9960022 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.4960022 136.52200317 Tm [(site)] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.51699829 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.01699829 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.29400635 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(activat)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.39400101 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.89400101 152.12199402 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.84799957 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.34799957 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.19000244 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.69000244 152.12199402 Tm [(do)1(wnstr)1(e)-1(am)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.28999329 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.78999329 152.12199402 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.47200012 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.97200012 152.12199402 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.19400024 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.69400024 152.12199402 Tm [(inhibit)] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.06799316 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.56799316 152.12199402 Tm [(gr)1(owt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 167.72200012 Tm [(and/or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.32300186 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.82300186 167.72200012 Tm [(invasion,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.45800018 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.95800018 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.23500061 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.73500061 167.72200012 Tm [(th)1(us)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.34100342 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.84100342 167.72200012 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.58200073 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.08200073 167.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.2230072 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.7230072 167.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.69799805 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.19799805 167.72200012 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.68800354 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.18800354 167.72200012 Tm [(supp)1(re)-1(ss)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 2.16700006 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 6.66699982 183.32200623 Tm [(Mutant)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.39899826 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.89899826 183.32200623 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.74100113 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.24100113 183.32200623 Tm [(p53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.54499817 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.04499817 183.32200623 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.26699829 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.76699829 183.32200623 Tm [(frequently)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.89700317 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.39700317 183.32200623 Tm [(occ)-1(ur)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.1269989 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.6269989 183.32200623 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.56799316 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.06799316 183.32200623 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.04299927 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.54299927 183.32200623 Tm [(number)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.35899353 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.85899353 183.32200623 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.70100403 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.20100403 183.32200623 Tm [(dif)1(fe)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(rent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.44199944 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.94199944 198.92199707 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.98300171 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.48300171 198.92199707 Tm [(canc)-1(ers)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.73899841 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.23899841 198.92199707 Tm [(fa)1(i)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.12400055 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.62400055 198.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.6989975 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.1989975 198.92199707 Tm [(bind)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.64500427 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.14500427 198.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.14599609 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.64599609 198.92199707 Tm [(conse)-1(nsus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.1230011 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.6230011 198.92199707 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.12800598 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.62800598 198.92199707 Tm [(bindin)] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 142.05000305 0.75 m 142.05000305 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
endstream
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6 0 obj
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