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1 0 0 -1 0 841.90002441 cm /Artifact <</Attached [/Top ] /BBox [90 695.85003662 505.29998779 799.35003662] /Type /Pagination >> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [(  )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <</Lang (zh-CN) /MCID 0 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 73.75099945 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <</MCID 1 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 145.51499939 23.67700005 Tm 0 Tr [(TP53BP1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 2 >> BDC BT /FAAABB 22 Tf 1 0 0 -1 231.10899353 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <</MCID 3 >> BDC BT /FAAABG 22 Tf 1 0 0 -1 341.54901123 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <</Lang (zh-CN) /MCID 4 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000A000B000C000D000E>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TP53BP)1(1)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 137.39199829 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 189.89199829 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 195.14199829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000F000B000C000D000E>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TP5)1(3BP1)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 121.375 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 123.74900055 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 152.52099609 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 154.89500427 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 205.21600342 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 207.58999634 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 245.38600159 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(tumo)-1(r)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 89.6190033 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 91.99299622 12.82499981 Tm [(protein)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 123.375 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 125.74900055 12.82499981 Tm [(p53)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 141.90899658 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 144.28300476 12.82499981 Tm [(bi)-1(nd)-1(in)-1(g)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 176.11099243 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 33 >> BDC BT 1 0 0 -1 178.48500061 12.82499981 Tm [(protein)] TJ ET EMC /P <</MCID 34 >> BDC BT 1 0 0 -1 209.86700439 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 35 >> BDC BT 1 0 0 -1 212.24099731 12.82499981 Tm [(1;)] TJ ET EMC /P <</MCID 36 >> BDC BT 1 0 0 -1 220.37199402 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 222.7460022 12.82499981 Tm [(TP53;)] TJ ET EMC /P <</MCID 38 >> BDC BT 1 0 0 -1 246.74000549 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 39 >> BDC BT 1 0 0 -1 249.11399841 12.82499981 Tm [(p202;)] TJ ET EMC /P <</MCID 40 >> BDC BT 1 0 0 -1 273.40600586 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 41 >> BDC BT 1 0 0 -1 275.77999878 12.82499981 Tm [(53BP)1(1;)] TJ ET EMC /P <</MCID 42 >> BDC BT 1 0 0 -1 305.69100952 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 43 >> BDC BT 1 0 0 -1 308.06500244 12.82499981 Tm [(TD)-1(RD30)1(;)] TJ ET EMC /P <</MCID 44 >> BDC BT 1 0 0 -1 345.25601196 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 45 >> BDC BT 1 0 0 -1 347.63000488 12.82499981 Tm [(p53BP1)] TJ ET EMC /P <</MCID 46 >> BDC BT 1 0 0 -1 380.24798584 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 47 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130010000E>] TJ ET EMC /P <</MCID 48 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 49 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <</MCID 50 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 51 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 52 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <</MCID 53 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 54 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <</MCID 55 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 56 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 57 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 58 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 59 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 60 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C>] TJ ET EMC /P <</MCID 61 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 62 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001D000E>] TJ ET EMC /P <</MCID 63 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 65 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 66 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0005>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 69 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001E000E>] TJ ET EMC /P <</MCID 70 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TP53BP)1(1)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 100.64199829 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 73 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001F002000210022000E>] TJ ET EMC /P <</MCID 74 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 75 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 77 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0023>] TJ ET EMC /P <</MCID 78 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 79 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0024>] TJ ET EMC /P <</MCID 80 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 81 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0025000E>] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 83 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 84 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 85 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 86 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0007000800130026000E>] TJ ET EMC /P <</MCID 87 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 92 >> BDC q /GS2 gs 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 93 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 94 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q /GS2 gs 1 g 0.375 0.75 m 158.92500305 0.75 l 158.92500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 159.92500305 -0.25 l 159.92500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 95 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 105.3219986 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 96 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 159.67500305 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 159.67500305 203.55000305 l h f* Q q 1 0 0 1 159.30000305 0 cm -0.625 -0.25 m 264.125 -0.25 l 264.125 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 97 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 128.977005 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 133.477005 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 150.69900513 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 155.19900513 11.72200012 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 195.10600281 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 199.60600281 11.72200012 Tm [(in)] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 207.54699707 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 212.04699707 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 226.04800415 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 230.54800415 11.72200012 Tm [(DNA)] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 251.05299377 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(do)1(u)-1(b)1(le)-1(-)1(stra)1(n)-1(d)] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 61.40000153 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 65.90000153 27.3220005 Tm [(break)] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 90.06600189 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 94.56600189 27.3220005 Tm [(repair)] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 119.66300201 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 124.16300201 27.3220005 Tm [(pa)1(thw)1(ay)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 160.62399292 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 165.12399292 27.3220005 Tm [(choic)-1(e,)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 195.08200073 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 199.58200073 27.3220005 Tm [(pro)1(moting)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 245.69400024 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 250.19400024 27.3220005 Tm [(n)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(on-h)1(omolog)1(ous)] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 69.88600159 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 74.38600159 42.92200089 Tm [(en)-1(d)] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 90.79499817 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 95.29499817 42.92200089 Tm [(joining)] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 125.05899811 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 129.55900574 42.92200089 Tm [(\(NHEJ\))] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 158.36099243 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 162.86099243 42.92200089 Tm [(pa)1(thw)1(ays,)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 205.65499878 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 210.15499878 42.92200089 Tm [(and)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 226.43200684 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 230.93200684 42.92200089 Tm [(limiti)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ng)] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 11.30300045 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 15.80300045 58.52199936 Tm [(ho)1(mologo)1(u)-1(s)] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 70.52799988 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 75.02799988 58.52199936 Tm [(rec)-1(o)1(mbination.)] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 140.08500671 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 144.58500671 58.52199936 Tm [(This)] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 161.84700012 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 166.34700012 58.52199936 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 197.65400696 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 202.15400696 58.52199936 Tm [(plays)] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 224.20100403 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 228.70100403 58.52199936 Tm [(multi)] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ple)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 13.25 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 17.75 74.12200165 Tm [(roles)] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 38.57600021 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 43.07600021 74.12200165 Tm [(in)] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 51.01699829 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 55.51699829 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 69.51799774 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 74.01799774 74.12200165 Tm [(DNA)] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 94.52300262 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 99.02300262 74.12200165 Tm [(da)1(mage)] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 134.0249939 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 138.5249939 74.12200165 Tm [(response,)] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 179.68899536 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 184.18899536 74.12200165 Tm [(inc)-1(luding)] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 224.03900146 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 228.53900146 74.12200165 Tm [(pro)1(m)] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ot)1(in)-1(g)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 22.77199936 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 27.27199936 89.72200012 Tm [(che)-1(ckpoint)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 74.61000061 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 79.11000061 89.72200012 Tm [(signaling)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 118.04100037 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 122.54100037 89.72200012 Tm [(fo)1(l)-1(lo)1(wing)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 162.69799805 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 167.19799805 89.72200012 Tm [(DNA)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 187.70300293 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 192.20300293 89.72200012 Tm [(da)1(mage,)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 229.37199402 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 233.87199402 89.72200012 Tm [(actin)] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(g)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 5.75699997 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 10.25699997 105.3219986 Tm [(as)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 19.39800072 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 23.89800072 105.3219986 Tm [(a)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 28.87299919 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 33.3730011 105.3219986 Tm [(scaff)1(old)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 67.14099884 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 71.64099884 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 83.91899872 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 88.41899872 105.3219986 Tm [(rec)-1(ruit)1(me)-1(nt)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 138.64399719 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 143.14399719 105.3219986 Tm [(of)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 151.98599243 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 156.48599243 105.3219986 Tm [(DNA)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 176.99099731 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 181.49099731 105.3219986 Tm [(da)1(mage)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 216.49299622 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 220.99299622 105.3219986 Tm [(respons)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(e)] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 5.10599995 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 9.60599995 120.92199707 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 45.07899857 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 49.57899857 120.92199707 Tm [(to)] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 58.65399933 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 63.15399933 120.92199707 Tm [(da)1(maged)] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 103.91300201 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 108.41300201 120.92199707 Tm [(chromat)1(in,)] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 154.4940033 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 158.9940033 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 175.27099609 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 179.77099609 120.92199707 Tm [(pro)1(moting)] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 225.88299561 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 230.38299561 120.92199707 Tm [(NHEJ)] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 253.17300415 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(pa)1(thw)1(ays)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 40.6269989 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 45.1269989 136.52200317 Tm [(by)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 55.63899994 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 60.13899994 136.52200317 Tm [(limiting)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 92.80799866 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 97.30799866 136.52200317 Tm [(en)-1(d)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 113.71700287 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 118.21700287 136.52200317 Tm [(resec)-1(tio)1(n)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 157.56100464 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 162.06100464 136.52200317 Tm [(fo)1(l)-1(lo)1(wing)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 202.21800232 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 206.71800232 136.52200317 Tm [(a)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 211.69299316 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 216.19299316 136.52200317 Tm [(do)1(u)-1(b)1(le)-1(-)1(s)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(tr)1(and)] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 23.06699944 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 27.56699944 152.12199402 Tm [(break.)] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 53.89899826 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 58.39899826 152.12199402 Tm [(These)] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 83.47899628 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 87.97899628 152.12199402 Tm [(roles)] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 108.80500031 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 113.30500031 152.12199402 Tm [(are)] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 126.82299805 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 131.32299805 152.12199402 Tm [(also)] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 148.58000183 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 153.08000183 152.12199402 Tm [(impor)1(tant)] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 196.04100037 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 200.54100037 152.12199402 Tm [(during)] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 228.97799683 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 233.47799683 152.12199402 Tm [(V\(D\)J)] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 255.9960022 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(rec)-1(o)1(mbination,)] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 65.05699921 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 69.55699921 167.72200012 Tm [(cl)-1(a)1(ss)] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 89.77200317 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 94.27200317 167.72200012 Tm [(sw)1(i)-1(t)1(c)-1(h)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 121.34700012 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 125.84700012 167.72200012 Tm [(rec)-1(o)1(mbination)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 188.73699951 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 193.23699951 167.72200012 Tm [(and)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 209.51400757 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 214.01400757 167.72200012 Tm [(at)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 222.34199524 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 226.84199524 167.72200012 Tm [(unpro)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(tected)] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 27.18899918 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 31.68899918 183.32200623 Tm [(telomeres.)] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 76.68000031 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 81.18000031 183.32200623 Tm [(Alt)1(e)-1(rna)1(tive)] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 127.90299988 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 132.40299988 183.32200623 Tm [(splicin)-1(g)] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 165.31799316 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 169.81799316 183.32200623 Tm [(results)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 197.98699951 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 202.48699951 183.32200623 Tm [(in)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 210.42799377 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 214.92799377 183.32200623 Tm [(multiple)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 250.30000305 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 0 198.92199707 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 40.92200089 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 45.42200089 198.92199707 Tm [(var)1(i)-1(a)1(n)-1(t)1(s)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 78.99199677 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 83.49199677 198.92199707 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 123.83399963 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 128.33399963 198.92199707 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 165.27400208 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 169.77400208 198.92199707 Tm [(isof)1(orms.)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 209.10099792 198.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 159.30000305 0.75 m 159.30000305 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
endobj
6 0 obj
<</Length1 124 0 R/Length 27804>>stream
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