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Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <</MCID 5 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(  )] TJ ET EMC /P <</Lang (zh-CN) /MCID 6 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <</MCID 7 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TNN)1(I2)] TJ ET EMC /P <</Lang (zh-CN) /MCID 8 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 126.38999939 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <</MCID 9 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 178.88999939 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 10 >> BDC BT 1 0 0 -1 184.13999939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <</Lang (zh-CN) /MCID 11 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <</MCID 12 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 13 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TN)1(NI2)] TJ ET EMC /P <</MCID 14 >> BDC BT 1 0 0 -1 110.3730011 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 15 >> BDC BT 1 0 0 -1 112.74700165 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <</MCID 16 >> BDC BT 1 0 0 -1 141.51899719 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 17 >> BDC BT 1 0 0 -1 143.89300537 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 18 >> BDC BT 1 0 0 -1 194.21400452 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 19 >> BDC BT 1 0 0 -1 196.58799744 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <</MCID 20 >> BDC BT 1 0 0 -1 234.38400269 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <</Lang (zh-CN) /MCID 21 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <</MCID 22 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 23 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <</MCID 24 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 25 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(AMCD2B;)] TJ ET EMC /P <</MCID 26 >> BDC BT 1 0 0 -1 103.95400238 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 27 >> BDC BT 1 0 0 -1 106.32800293 12.82499981 Tm [(DA2B;)] TJ ET EMC /P <</MCID 28 >> BDC BT 1 0 0 -1 132.70599365 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 29 >> BDC BT 1 0 0 -1 135.08000183 12.82499981 Tm [(FS)-1(SV)-1(;)] TJ ET EMC /P <</MCID 30 >> BDC BT 1 0 0 -1 158.32000732 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 31 >> BDC BT 1 0 0 -1 160.69400024 12.82499981 Tm [(fsT)-1(nI)] TJ ET EMC /P <</MCID 32 >> BDC BT 1 0 0 -1 181.28399658 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <</Lang (zh-CN) /MCID 33 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <</MCID 34 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 35 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <</MCID 36 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 37 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <</Lang (zh-CN) /MCID 38 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <</MCID 39 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 40 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <</MCID 41 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 42 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <</MCID 43 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <</Lang (zh-CN) /MCID 44 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <</MCID 45 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 46 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001C001D>] TJ ET EMC /P <</MCID 47 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <</Lang (zh-CN) /MCID 48 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E>] TJ ET EMC /P <</MCID 49 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 50 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000E>] TJ ET EMC /P <</MCID 51 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 52 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <</MCID 53 >> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 54 >> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <</Lang (zh-CN) /MCID 55 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <</MCID 56 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [(    )] TJ ET EMC /P <</Lang (zh-CN) /MCID 57 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0020000E>] TJ ET EMC /P <</MCID 58 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 59 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TNN)1(I2)] TJ ET EMC /P <</MCID 60 >> BDC BT 1 0 0 -1 89.63999939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <</Lang (zh-CN) /MCID 61 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0021002200230024000E>] TJ ET EMC /P <</MCID 62 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 63 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <</MCID 64 >> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <</Lang (zh-CN) /MCID 65 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0025>] TJ ET EMC /P <</MCID 66 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 67 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0026>] TJ ET EMC /P <</MCID 68 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <</Lang (zh-CN) /MCID 69 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0027000E>] TJ ET EMC /P <</MCID 70 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 71 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <</MCID 72 >> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 73 >> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <</Lang (zh-CN) /MCID 74 >> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130028000E>] TJ ET EMC /P <</MCID 75 >> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <</MCID 76 >> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <</MCID 77 >> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <</MCID 78 >> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <</MCID 79 >> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <</MCID 80 >> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <</Lang (zh-CN) /MCID 81 >> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <</MCID 82 >> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 164.17500305 0.75 l 164.17500305 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 165.17500305 -0.25 l 165.17500305 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 83 >> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 105.3219986 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <</MCID 84 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 164.92500305 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 164.92500305 203.55000305 l h f* Q q 1 0 0 1 164.55000305 0 cm -0.625 -0.25 m 258.875 -0.25 l 258.875 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <</MCID 85 >> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(This)] TJ ET EMC /P <</MCID 86 >> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 87 >> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <</MCID 88 >> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 89 >> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <</MCID 90 >> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 91 >> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <</MCID 92 >> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 93 >> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(fa)1(st-)1(twit)1(c)-1(h)] TJ ET EMC /P <</MCID 94 >> BDC BT 1 0 0 -1 143.43899536 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 95 >> BDC BT 1 0 0 -1 147.93899536 11.72200012 Tm [(ske)-1(leta)1(l)] TJ ET EMC /P <</MCID 96 >> BDC BT 1 0 0 -1 180.33500671 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 97 >> BDC BT 1 0 0 -1 184.83500671 11.72200012 Tm [(musc)-1(le)] TJ ET EMC /P <</MCID 98 >> BDC BT 1 0 0 -1 214.99499512 11.72200012 Tm [( )] TJ ET EMC /P <</MCID 99 >> BDC BT 1 0 0 -1 219.49499512 11.72200012 Tm [(pro)1(tei)] TJ ET EMC /P <</MCID 100 >> BDC BT 1 0 0 -1 0 27.3220005 Tm [(n,)] TJ ET EMC /P <</MCID 101 >> BDC BT 1 0 0 -1 7.71199989 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 102 >> BDC BT 1 0 0 -1 12.21199989 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 103 >> BDC BT 1 0 0 -1 17.18700027 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 104 >> BDC BT 1 0 0 -1 21.68700027 27.3220005 Tm [(member)] TJ ET EMC /P <</MCID 105 >> BDC BT 1 0 0 -1 57.95100021 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 106 >> BDC BT 1 0 0 -1 62.45100021 27.3220005 Tm [(of)] TJ ET EMC /P <</MCID 107 >> BDC BT 1 0 0 -1 71.29299927 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 108 >> BDC BT 1 0 0 -1 75.79299927 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <</MCID 109 >> BDC BT 1 0 0 -1 89.79399872 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 110 >> BDC BT 1 0 0 -1 94.29399872 27.3220005 Tm [(tr)1(oponin)] TJ ET EMC /P <</MCID 111 >> BDC BT 1 0 0 -1 131.76199341 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 112 >> BDC BT 1 0 0 -1 136.26199341 27.3220005 Tm [(I)] TJ ET EMC /P <</MCID 113 >> BDC BT 1 0 0 -1 138.90800476 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 114 >> BDC BT 1 0 0 -1 143.40800476 27.3220005 Tm [(gene)] TJ ET EMC /P <</MCID 115 >> BDC BT 1 0 0 -1 164.92399597 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 116 >> BDC BT 1 0 0 -1 169.42399597 27.3220005 Tm [(fa)1(mi)-1(ly,)] TJ ET EMC /P <</MCID 117 >> BDC BT 1 0 0 -1 197.67199707 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 118 >> BDC BT 1 0 0 -1 202.17199707 27.3220005 Tm [(and)] TJ ET EMC /P <</MCID 119 >> BDC BT 1 0 0 -1 218.44900513 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 120 >> BDC BT 1 0 0 -1 222.94900513 27.3220005 Tm [(a)] TJ ET EMC /P <</MCID 121 >> BDC BT 1 0 0 -1 227.92399597 27.3220005 Tm [( )] TJ ET EMC /P <</MCID 122 >> BDC BT 1 0 0 -1 232.42399597 27.3220005 Tm [(co)] TJ ET EMC /P <</MCID 123 >> BDC BT 1 0 0 -1 0 42.92200089 Tm [(mpo)1(n)-1(ent)] TJ ET EMC /P <</MCID 124 >> BDC BT 1 0 0 -1 39.45399857 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 125 >> BDC BT 1 0 0 -1 43.95399857 42.92200089 Tm [(of)] TJ ET EMC /P <</MCID 126 >> BDC BT 1 0 0 -1 52.79600143 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 127 >> BDC BT 1 0 0 -1 57.29600143 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <</MCID 128 >> BDC BT 1 0 0 -1 71.29699707 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 129 >> BDC BT 1 0 0 -1 75.79699707 42.92200089 Tm [(tr)1(oponin)] TJ ET EMC /P <</MCID 130 >> BDC BT 1 0 0 -1 113.26499939 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 131 >> BDC BT 1 0 0 -1 117.76499939 42.92200089 Tm [(complex)] TJ ET EMC /P <</MCID 132 >> BDC BT 1 0 0 -1 154.2440033 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 133 >> BDC BT 1 0 0 -1 158.7440033 42.92200089 Tm [(inc)-1(luding)] TJ ET EMC /P <</MCID 134 >> BDC BT 1 0 0 -1 198.59399414 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 135 >> BDC BT 1 0 0 -1 203.09399414 42.92200089 Tm [(tr)1(oponin)] TJ ET EMC /P <</MCID 136 >> BDC BT 1 0 0 -1 240.56199646 42.92200089 Tm [( )] TJ ET EMC /P <</MCID 137 >> BDC BT 1 0 0 -1 245.06199646 42.92200089 Tm [(T)] TJ ET EMC /P <</MCID 138 >> BDC BT 1 0 0 -1 0 58.52199936 Tm [(,)] TJ ET EMC /P <</MCID 139 >> BDC BT 1 0 0 -1 2.16700006 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 140 >> BDC BT 1 0 0 -1 6.66699982 58.52199936 Tm [(tr)1(oponin)] TJ ET EMC /P <</MCID 141 >> BDC BT 1 0 0 -1 44.13499832 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 142 >> BDC BT 1 0 0 -1 48.63499832 58.52199936 Tm [(C)] TJ ET EMC /P <</MCID 143 >> BDC BT 1 0 0 -1 54.65599823 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 144 >> BDC BT 1 0 0 -1 59.15599823 58.52199936 Tm [(and)] TJ ET EMC /P <</MCID 145 >> BDC BT 1 0 0 -1 75.43299866 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 146 >> BDC BT 1 0 0 -1 79.93299866 58.52199936 Tm [(tr)1(oponin)] TJ ET EMC /P <</MCID 147 >> BDC BT 1 0 0 -1 117.40100098 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 148 >> BDC BT 1 0 0 -1 121.90100098 58.52199936 Tm [(I)] TJ ET EMC /P <</MCID 149 >> BDC BT 1 0 0 -1 124.54699707 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 150 >> BDC BT 1 0 0 -1 129.04699707 58.52199936 Tm [(subunits.)] TJ ET EMC /P <</MCID 151 >> BDC BT 1 0 0 -1 167.67900085 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 152 >> BDC BT 1 0 0 -1 172.17900085 58.52199936 Tm [(The)] TJ ET EMC /P <</MCID 153 >> BDC BT 1 0 0 -1 187.98599243 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 154 >> BDC BT 1 0 0 -1 192.48599243 58.52199936 Tm [(tr)1(oponin)] TJ ET EMC /P <</MCID 155 >> BDC BT 1 0 0 -1 229.95399475 58.52199936 Tm [( )] TJ ET EMC /P <</MCID 156 >> BDC BT 1 0 0 -1 234.45399475 58.52199936 Tm [(co)] TJ ET EMC /P <</MCID 157 >> BDC BT 1 0 0 -1 0 74.12200165 Tm [(mplex,)] TJ ET EMC /P <</MCID 158 >> BDC BT 1 0 0 -1 28.4109993 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 159 >> BDC BT 1 0 0 -1 32.9109993 74.12200165 Tm [(along)] TJ ET EMC /P <</MCID 160 >> BDC BT 1 0 0 -1 57.30500031 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 161 >> BDC BT 1 0 0 -1 61.80500031 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <</MCID 162 >> BDC BT 1 0 0 -1 80.2009964 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 163 >> BDC BT 1 0 0 -1 84.7009964 74.12200165 Tm [(tr)1(opomyos)1(i)-1(n,)] TJ ET EMC /P <</MCID 164 >> BDC BT 1 0 0 -1 141.87399292 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 165 >> BDC BT 1 0 0 -1 146.37399292 74.12200165 Tm [(is)] TJ ET EMC /P <</MCID 166 >> BDC BT 1 0 0 -1 152.93499756 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 167 >> BDC BT 1 0 0 -1 157.43499756 74.12200165 Tm [(responsib)1(l)-1(e)] TJ ET EMC /P <</MCID 168 >> BDC BT 1 0 0 -1 206.97000122 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 169 >> BDC BT 1 0 0 -1 211.47000122 74.12200165 Tm [(fo)1(r)] TJ ET EMC /P <</MCID 170 >> BDC BT 1 0 0 -1 223.7480011 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 171 >> BDC BT 1 0 0 -1 228.2480011 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <</MCID 172 >> BDC BT 1 0 0 -1 242.24899292 74.12200165 Tm [( )] TJ ET EMC /P <</MCID 173 >> BDC BT 1 0 0 -1 0 89.72200012 Tm [(calc)-1(ium-d)1(e)-1(p)1(e)-1(ndent)] TJ ET EMC /P <</MCID 174 >> BDC BT 1 0 0 -1 83.68900299 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 175 >> BDC BT 1 0 0 -1 88.18900299 89.72200012 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 176 >> BDC BT 1 0 0 -1 132.41999817 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 177 >> BDC BT 1 0 0 -1 136.91999817 89.72200012 Tm [(of)] TJ ET EMC /P <</MCID 178 >> BDC BT 1 0 0 -1 145.76199341 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 179 >> BDC BT 1 0 0 -1 150.26199341 89.72200012 Tm [(st)1(riated)] TJ ET EMC /P <</MCID 180 >> BDC BT 1 0 0 -1 182.80400085 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 181 >> BDC BT 1 0 0 -1 187.30400085 89.72200012 Tm [(musc)-1(le)] TJ ET EMC /P <</MCID 182 >> BDC BT 1 0 0 -1 217.46400452 89.72200012 Tm [( )] TJ ET EMC /P <</MCID 183 >> BDC BT 1 0 0 -1 221.96400452 89.72200012 Tm [(contra)] TJ ET EMC /P <</MCID 184 >> BDC BT 1 0 0 -1 0 105.3219986 Tm [(ction.)] TJ ET EMC /P <</MCID 185 >> BDC BT 1 0 0 -1 23.69499969 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 186 >> BDC BT 1 0 0 -1 28.19499969 105.3219986 Tm [(Mouse)] TJ ET EMC /P <</MCID 187 >> BDC BT 1 0 0 -1 57.52799988 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 188 >> BDC BT 1 0 0 -1 62.02799988 105.3219986 Tm [(st)1(u)-1(d)1(ie)-1(s)] TJ ET EMC /P <</MCID 189 >> BDC BT 1 0 0 -1 92.51699829 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 190 >> BDC BT 1 0 0 -1 97.01699829 105.3219986 Tm [(sho)1(w)] TJ ET EMC /P <</MCID 191 >> BDC BT 1 0 0 -1 119.55200195 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 192 >> BDC BT 1 0 0 -1 124.05200195 105.3219986 Tm [(th)1(at)] TJ ET EMC /P <</MCID 193 >> BDC BT 1 0 0 -1 141.27400208 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 194 >> BDC BT 1 0 0 -1 145.77400208 105.3219986 Tm [(th)1(is)] TJ ET EMC /P <</MCID 195 >> BDC BT 1 0 0 -1 161.22999573 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 196 >> BDC BT 1 0 0 -1 165.72999573 105.3219986 Tm [(component)] TJ ET EMC /P <</MCID 197 >> BDC BT 1 0 0 -1 215.41900635 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 198 >> BDC BT 1 0 0 -1 219.91900635 105.3219986 Tm [(is)] TJ ET EMC /P <</MCID 199 >> BDC BT 1 0 0 -1 226.47999573 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 200 >> BDC BT 1 0 0 -1 230.97999573 105.3219986 Tm [(also)] TJ ET EMC /P <</MCID 201 >> BDC BT 1 0 0 -1 248.23699951 105.3219986 Tm [( )] TJ ET EMC /P <</MCID 202 >> BDC BT 1 0 0 -1 0 120.92199707 Tm [(present)] TJ ET EMC /P <</MCID 203 >> BDC BT 1 0 0 -1 32.4620018 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 204 >> BDC BT 1 0 0 -1 36.9620018 120.92199707 Tm [(in)] TJ ET EMC /P <</MCID 205 >> BDC BT 1 0 0 -1 44.90299988 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 206 >> BDC BT 1 0 0 -1 49.40299988 120.92199707 Tm [(vascular)] TJ ET EMC /P <</MCID 207 >> BDC BT 1 0 0 -1 84.13300323 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 208 >> BDC BT 1 0 0 -1 88.63300323 120.92199707 Tm [(smoo)1(th)] TJ ET EMC /P <</MCID 209 >> BDC BT 1 0 0 -1 121.56999969 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 210 >> BDC BT 1 0 0 -1 126.06999969 120.92199707 Tm [(musc)-1(le)] TJ ET EMC /P <</MCID 211 >> BDC BT 1 0 0 -1 156.22999573 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 212 >> BDC BT 1 0 0 -1 160.72999573 120.92199707 Tm [(and)] TJ ET EMC /P <</MCID 213 >> BDC BT 1 0 0 -1 177.00700378 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 214 >> BDC BT 1 0 0 -1 181.50700378 120.92199707 Tm [(may)] TJ ET EMC /P <</MCID 215 >> BDC BT 1 0 0 -1 199.67799377 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 216 >> BDC BT 1 0 0 -1 204.17799377 120.92199707 Tm [(play)] TJ ET EMC /P <</MCID 217 >> BDC BT 1 0 0 -1 222.05900574 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 218 >> BDC BT 1 0 0 -1 226.55900574 120.92199707 Tm [(a)] TJ ET EMC /P <</MCID 219 >> BDC BT 1 0 0 -1 231.53399658 120.92199707 Tm [( )] TJ ET EMC /P <</MCID 220 >> BDC BT 1 0 0 -1 236.03399658 120.92199707 Tm [(rol)] TJ ET EMC /P <</MCID 221 >> BDC BT 1 0 0 -1 0 136.52200317 Tm [(e)] TJ ET EMC /P <</MCID 222 >> BDC BT 1 0 0 -1 5.10599995 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 223 >> BDC BT 1 0 0 -1 9.60599995 136.52200317 Tm [(in)] TJ ET EMC /P <</MCID 224 >> BDC BT 1 0 0 -1 17.54700089 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 225 >> BDC BT 1 0 0 -1 22.04700089 136.52200317 Tm [(regulat)1(i)-1(o)1(n)] TJ ET EMC /P <</MCID 226 >> BDC BT 1 0 0 -1 66.27799988 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 227 >> BDC BT 1 0 0 -1 70.77799988 136.52200317 Tm [(of)] TJ ET EMC /P <</MCID 228 >> BDC BT 1 0 0 -1 79.62000275 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 229 >> BDC BT 1 0 0 -1 84.12000275 136.52200317 Tm [(smoo)1(th)] TJ ET EMC /P <</MCID 230 >> BDC BT 1 0 0 -1 117.05699921 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 231 >> BDC BT 1 0 0 -1 121.55699921 136.52200317 Tm [(musc)-1(le)] TJ ET EMC /P <</MCID 232 >> BDC BT 1 0 0 -1 151.71699524 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 233 >> BDC BT 1 0 0 -1 156.21699524 136.52200317 Tm [(func)-1(t)1(ion.)] TJ ET EMC /P <</MCID 234 >> BDC BT 1 0 0 -1 194.12399292 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 235 >> BDC BT 1 0 0 -1 198.62399292 136.52200317 Tm [(In)] TJ ET EMC /P <</MCID 236 >> BDC BT 1 0 0 -1 206.81500244 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 237 >> BDC BT 1 0 0 -1 211.31500244 136.52200317 Tm [(ad)1(dition)] TJ ET EMC /P <</MCID 238 >> BDC BT 1 0 0 -1 247.21400452 136.52200317 Tm [( )] TJ ET EMC /P <</MCID 239 >> BDC BT 1 0 0 -1 0 152.12199402 Tm [(to)] TJ ET EMC /P <</MCID 240 >> BDC BT 1 0 0 -1 9.07499981 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 241 >> BDC BT 1 0 0 -1 13.57499981 152.12199402 Tm [(musc)-1(le)] TJ ET EMC /P <</MCID 242 >> BDC BT 1 0 0 -1 43.73500061 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 243 >> BDC BT 1 0 0 -1 48.23500061 152.12199402 Tm [(tiss)1(u)-1(es,)] TJ ET EMC /P <</MCID 244 >> BDC BT 1 0 0 -1 79.30000305 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 245 >> BDC BT 1 0 0 -1 83.80000305 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <</MCID 246 >> BDC BT 1 0 0 -1 99.2559967 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 247 >> BDC BT 1 0 0 -1 103.7559967 152.12199402 Tm [(pro)1(tein)] TJ ET EMC /P <</MCID 248 >> BDC BT 1 0 0 -1 135.06300354 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 249 >> BDC BT 1 0 0 -1 139.56300354 152.12199402 Tm [(is)] TJ ET EMC /P <</MCID 250 >> BDC BT 1 0 0 -1 146.12399292 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 251 >> BDC BT 1 0 0 -1 150.62399292 152.12199402 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <</MCID 252 >> BDC BT 1 0 0 -1 176.31399536 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 253 >> BDC BT 1 0 0 -1 180.81399536 152.12199402 Tm [(in)] TJ ET EMC /P <</MCID 254 >> BDC BT 1 0 0 -1 188.75500488 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 255 >> BDC BT 1 0 0 -1 193.25500488 152.12199402 Tm [(corne)-1(a)1(l)] TJ ET EMC /P <</MCID 256 >> BDC BT 1 0 0 -1 224.94799805 152.12199402 Tm [( )] TJ ET EMC /P <</MCID 257 >> BDC BT 1 0 0 -1 229.44799805 152.12199402 Tm [(epit)] TJ ET EMC /P <</MCID 258 >> BDC BT 1 0 0 -1 0 167.72200012 Tm [(heliu)-1(m,)] TJ ET EMC /P <</MCID 259 >> BDC BT 1 0 0 -1 31.58300018 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 260 >> BDC BT 1 0 0 -1 36.08300018 167.72200012 Tm [(cartilag)1(e)] TJ ET EMC /P <</MCID 261 >> BDC BT 1 0 0 -1 72.98799896 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 262 >> BDC BT 1 0 0 -1 77.48799896 167.72200012 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <</MCID 263 >> BDC BT 1 0 0 -1 103.78500366 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 264 >> BDC BT 1 0 0 -1 108.28500366 167.72200012 Tm [(it)] TJ ET EMC /P <</MCID 265 >> BDC BT 1 0 0 -1 114.03299713 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 266 >> BDC BT 1 0 0 -1 118.53299713 167.72200012 Tm [(is)] TJ ET EMC /P <</MCID 267 >> BDC BT 1 0 0 -1 125.09400177 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 268 >> BDC BT 1 0 0 -1 129.59399414 167.72200012 Tm [(an)] TJ ET EMC /P <</MCID 269 >> BDC BT 1 0 0 -1 140.11500549 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 270 >> BDC BT 1 0 0 -1 144.61500549 167.72200012 Tm [(inhibito)1(r)] TJ ET EMC /P <</MCID 271 >> BDC BT 1 0 0 -1 181.14700317 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 272 >> BDC BT 1 0 0 -1 185.64700317 167.72200012 Tm [(of)] TJ ET EMC /P <</MCID 273 >> BDC BT 1 0 0 -1 194.48899841 167.72200012 Tm [( )] TJ ET EMC /P <</MCID 274 >> BDC BT 1 0 0 -1 198.98899841 167.72200012 Tm [(angio)1(gen)-1(es)] TJ ET EMC /P <</MCID 275 >> BDC BT 1 0 0 -1 0 183.32200623 Tm [(is)] TJ ET EMC /P <</MCID 276 >> BDC BT 1 0 0 -1 6.56099987 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 277 >> BDC BT 1 0 0 -1 11.06099987 183.32200623 Tm [(to)] TJ ET EMC /P <</MCID 278 >> BDC BT 1 0 0 -1 20.13599968 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 279 >> BDC BT 1 0 0 -1 24.63599968 183.32200623 Tm [(inhibit)] TJ ET EMC /P <</MCID 280 >> BDC BT 1 0 0 -1 52.00999832 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 281 >> BDC BT 1 0 0 -1 56.50999832 183.32200623 Tm [(tumor)] TJ ET EMC /P <</MCID 282 >> BDC BT 1 0 0 -1 83 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 283 >> BDC BT 1 0 0 -1 87.5 183.32200623 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <</MCID 284 >> BDC BT 1 0 0 -1 118.41600037 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 285 >> BDC BT 1 0 0 -1 122.91600037 183.32200623 Tm [(and)] TJ ET EMC /P <</MCID 286 >> BDC BT 1 0 0 -1 139.19299316 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 287 >> BDC BT 1 0 0 -1 143.69299316 183.32200623 Tm [(metast)1(asis,)] TJ ET EMC /P <</MCID 288 >> BDC BT 1 0 0 -1 190.94700623 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 289 >> BDC BT 1 0 0 -1 195.44700623 183.32200623 Tm [(and)] TJ ET EMC /P <</MCID 290 >> BDC BT 1 0 0 -1 211.72399902 183.32200623 Tm [( )] TJ ET EMC /P <</MCID 291 >> BDC BT 1 0 0 -1 216.22399902 183.32200623 Tm [(mamm)] TJ ET EMC /P <</MCID 292 >> BDC BT 1 0 0 -1 0 198.92199707 Tm [(ary)] TJ ET EMC /P <</MCID 293 >> BDC BT 1 0 0 -1 13.17500019 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 294 >> BDC BT 1 0 0 -1 17.67499924 198.92199707 Tm [(gla)1(n)-1(d)] TJ ET EMC /P <</MCID 295 >> BDC BT 1 0 0 -1 42.10400009 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 296 >> BDC BT 1 0 0 -1 46.60400009 198.92199707 Tm [(wh)1(e)-1(r)1(e)] TJ ET EMC /P <</MCID 297 >> BDC BT 1 0 0 -1 72.90100098 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 298 >> BDC BT 1 0 0 -1 77.40100098 198.92199707 Tm [(it)] TJ ET EMC /P <</MCID 299 >> BDC BT 1 0 0 -1 83.14900208 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 300 >> BDC BT 1 0 0 -1 87.64900208 198.92199707 Tm [(func)-1(t)1(ions)] TJ ET EMC /P <</MCID 301 >> BDC BT 1 0 0 -1 127.55599976 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 302 >> BDC BT 1 0 0 -1 132.05599976 198.92199707 Tm [(as)] TJ ET EMC /P <</MCID 303 >> BDC BT 1 0 0 -1 141.19700623 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 304 >> BDC BT 1 0 0 -1 145.69700623 198.92199707 Tm [(a)] TJ ET EMC /P <</MCID 305 >> BDC BT 1 0 0 -1 150.67199707 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 306 >> BDC BT 1 0 0 -1 155.17199707 198.92199707 Tm [(co-activa)1(tor)] TJ ET EMC /P <</MCID 307 >> BDC BT 1 0 0 -1 206.7460022 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 308 >> BDC BT 1 0 0 -1 211.2460022 198.92199707 Tm [(of)] TJ ET EMC /P <</MCID 309 >> BDC BT 1 0 0 -1 220.08799744 198.92199707 Tm [( )] TJ ET EMC /P <</MCID 310 >> BDC BT 1 0 0 -1 224.58799744 198.92199707 Tm [(estro)] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 164.55000305 0.75 m 164.55000305 203.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm 
endstream
endobj
6 0 obj
<</Length1 119 0 R/Length 27292>>stream
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