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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 86.11000061 23.67700005 Tm 0 g [(CAGE1)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 152.48599243 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 329.19000244 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(CAGE1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.74700165 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 96.99700165 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 180.99699402 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CAGE1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.74700165 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.1210022 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.32299805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.69700623 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.67700195 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.05099487 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.5249939 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(cancer)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.31099701 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.68499756 12.82499981 Tm [(anti)-1(ge)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.84100342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.21499634 12.82499981 Tm [(1;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.34599304 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.72000122 12.82499981 Tm [(CT)-1(3)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.56700134 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.94099426 12.82499981 Tm [(CT)-1(9)1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10899353 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.48300171 12.82499981 Tm [(CT)-1(A)1(G3;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.02900696 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40299988 12.82499981 Tm [(bA69L16.7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.66900635 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 236.83399963 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 282.71200562 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(501-7)1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(CAGE1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 340.4460144 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 311.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 339.58999634 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 385.46798706 cm q /GS2 gs 1 g 0.375 0.75 m 102.07499695 0.75 l 102.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.07499695 -0.25 l 103.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.82499695 16.35000038 l h f* Q q 1 0 0 1 102.44999695 0 cm -0.625 -0.25 m 324.7250061 -0.25 l 324.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.09000015 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.59000015 11.72200012 Tm [(antig)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.26799774 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.76799774 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.04599762 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 102.07499695 0.75 l 102.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.07499695 -0.25 l 103.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.82499695 16.35000038 l h f* Q q 1 0 0 1 102.44999695 0 cm -0.625 -0.25 m 324.7250061 -0.25 l 324.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(CT3)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.62400055 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.12400055 11.72200012 Tm [(CT9)-1(5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.02600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.52600098 11.72200012 Tm [(CTAG)1(3)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.17500305 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.67500305 11.72200012 Tm [(bA)1(6)-1(9L1)-1(6.7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.92999268 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 102.07499695 0.75 l 102.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.07499695 -0.25 l 103.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.82499695 16.35000038 l h f* Q q 1 0 0 1 102.44999695 0 cm -0.625 -0.25 m 324.7250061 -0.25 l 324.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8T)-1(C20)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.34799957 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 102.07499695 0.75 l 102.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.07499695 -0.25 l 103.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.82499695 16.35000038 l h f* Q q 1 0 0 1 102.44999695 0 cm -0.625 -0.25 m 324.7250061 -0.25 l 324.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(26)-1(19)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 102.07499695 0.75 l 102.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.07499695 -0.25 l 103.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.82499695 16.35000038 l h f* Q q 1 0 0 1 102.44999695 0 cm -0.625 -0.25 m 324.7250061 -0.25 l 324.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 102.07499695 0.75 l 102.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.07499695 -0.25 l 103.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.82499695 16.35000038 l h f* Q q 1 0 0 1 102.44999695 0 cm -0.625 -0.25 m 324.7250061 -0.25 l 324.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 102.07499695 0.75 l 102.07499695 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 103.07499695 -0.25 l 103.07499695 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.82499695 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 102.82499695 16.35000038 l h f* Q q 1 0 0 1 102.44999695 0 cm -0.625 -0.25 m 324.7250061 -0.25 l 324.7250061 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 102.07499695 0.75 l 102.07499695 94.34999847 l 0.375 94.34999847 l h f* Q q -0.625 -0.25 m 103.07499695 -0.25 l 103.07499695 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 50.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 50.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 102.82499695 0.75 m 426.17498779 0.75 l 426.17498779 94.34999847 l 102.82499695 94.34999847 l h f* Q q 1 0 0 1 102.44999695 0 cm -0.625 -0.25 m 324.7250061 -0.25 l 324.7250061 95.34999847 l -0.625 95.34999847 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Cance)-1(r-)1(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.61799622 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.11799622 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.63400269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.13400269 11.72200012 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.41200256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.91200256 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.21899414 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.71899414 11.72200012 Tm [(\(CAG)1(E1\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.00300598 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.50300598 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.06399536 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.56399536 11.72200012 Tm [(initially)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.17599487 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.67599487 11.72200012 Tm [(identified)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.60699463 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.10699463 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.24798584 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.74798584 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.72299194 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.22299194 11.72200012 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ance)-1(r/t)1(e)-1(st)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.96099854 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.46099854 27.3220005 Tm [(antig)1(e)-1(n.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.30500031 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.80500031 27.3220005 Tm [(CAG)1(E1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.07700348 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.57700348 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.13800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.63800049 27.3220005 Tm [(mainly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.14500427 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.64500427 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.61999512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.11999512 27.3220005 Tm [(nuc)-1(lear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.63800049 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.13800049 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.44500732 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.94500732 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.16699219 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.66699219 27.3220005 Tm [(disp)1(lays)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.03201294 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(hig)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.23500061 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.73500061 42.92200089 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.68900299 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.18900299 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.12999725 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.62999725 42.92200089 Tm [(test)1(i)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.16999817 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.66999817 42.92200089 Tm [(amo)1(n)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.102005 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.602005 42.92200089 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.10899353 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.60899353 42.92200089 Tm [(tiss)1(u)-1(es,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.67399597 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.17399597 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.45100403 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.95100403 42.92200089 Tm [(wid)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.31500244 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.81500244 42.92200089 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 310.76901245 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.94099998 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.44099998 58.52199936 Tm [(var)1(i)-1(o)1(u)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.40499878 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.90499878 58.52199936 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.99500275 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.49500275 58.52199936 Tm [(tiss)1(u)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.39299774 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.89299774 58.52199936 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.16999817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.66999817 58.52199936 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.75999451 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.25999451 58.52199936 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.66999817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.16999817 58.52199936 Tm [(line)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.94500732 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.44500732 58.52199936 Tm [(CAG)1(E1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.71699524 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.21699524 58.52199936 Tm [(may)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.38800049 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.88800049 58.52199936 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.74200439 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.24200439 58.52199936 Tm [(asso)1(c)-1(ia)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.2159996 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.7159996 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.11199951 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.61199951 74.12200165 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.10199738 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.60199738 74.12200165 Tm [(pro)1(gression,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.96900177 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.46899414 74.12200165 Tm [(wh)1(il)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.01300049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.51300049 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.51400757 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.01400757 74.12200165 Tm [(exact)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.522995 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.022995 74.12200165 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.76400757 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 243.26400757 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.10600281 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.60598755 74.12200165 Tm [(CAG)1(E-1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.77200317 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.27200317 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.83300781 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.33300781 74.12200165 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ot)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.07499981 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.57499981 89.72200012 Tm [(well)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.57699966 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.07699966 89.72200012 Tm [(understo)1(od.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.35399628 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.44999695 0.75 m 102.44999695 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.44999695 17.10000038 m 102.44999695 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.44999695 33.45000076 m 102.44999695 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.44999695 49.80000305 m 102.44999695 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.44999695 66.15000153 m 102.44999695 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.44999695 82.5 m 102.44999695 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.44999695 98.84999847 m 102.44999695 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 102.44999695 115.19999695 m 102.44999695 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 208.79998779 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 209.17498779 m 426.92498779 209.17498779 l S Q Q q 1 0 0 1 0 595.01800537 cm Q Q 1 0 0 -1 0 841.90002441 cm
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