%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 130 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 99 l -90 99 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 88 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 259.30001831 0 0 -86.55000305 0 86.55000305 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 141.55000305 cm q 1 0 0 1 66 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(TNFS)1(F10)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 155.54200745 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 265.98199463 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 86.625 12.82499981 Tm [(TNFS)-1(F10)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 126.26100159 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 178.76100159 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.01100159 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TN)1(F)-1(SF)-1(10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.74500275 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.1190033 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.89100647 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.26499939 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.58599854 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.96000671 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.7559967 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TNF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.71900177 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.09300232 12.82499981 Tm [(su)-1(pe)1(rfami)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.31199646 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.68600464 12.82499981 Tm [(me)1(mb)-1(e)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.08700562 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 173.46099854 12.82499981 Tm [(10;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.91400146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.28799438 12.82499981 Tm [(TL)-1(2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.94999695 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.32400513 12.82499981 Tm [(AP)1(O2L)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.32200623 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.69599915 12.82499981 Tm [(CD253;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.5289917 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.90301514 12.82499981 Tm [(TRAIL;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.66598511 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 305.04000854 12.82499981 Tm [(Apo-2L)-1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 337.9289856 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 340.30300903 12.82499981 Tm [(TNLG6A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 374.63299561 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001C>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<001E000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TNFS)-1(F10)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.01100159 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.37400055 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 281.57299805 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001F002000210022000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 315.11199951 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<002300240025000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 348.65100098 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130026000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 g -1.45000005 382.19000244 m 416.75 382.19000244 l 416.75 413.39001465 l -1.45000005 413.39001465 l h f* Q q 1 0 0 1 0 382.19000244 cm /P <> BDC q 1 g 0 6.59399986 m 42 6.59399986 l 42 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm 0.13333334 g [<0003000400050006>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 413.39001465 cm q 1 g 0.375 0.75 m 143.5249939 0.75 l 143.5249939 203.55000305 l 0.375 203.55000305 l h f* Q q -0.625 -0.25 m 144.5249939 -0.25 l 144.5249939 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 105.3219986 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 105.3219986 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 144.2749939 0.75 m 422.42498779 0.75 l 422.42498779 203.55000305 l 144.2749939 203.55000305 l h f* Q q 1 0 0 1 143.8999939 0 cm -0.625 -0.25 m 279.5249939 -0.25 l 279.5249939 204.55000305 l -0.625 204.55000305 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(cy)-1(t)1(oki)-1(ne)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.94000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.44000244 11.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.66200256 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.16200256 11.72200012 Tm [(belon)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(gs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.92300034 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.42300034 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.49799919 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.99799919 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.99900055 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.49900055 27.3220005 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.98899841 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.48899841 27.3220005 Tm [(ne)-1(crosis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.54000092 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.04000092 27.3220005 Tm [(fa)1(c)-1(t)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.15899658 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.65899658 27.3220005 Tm [(\(TNF\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.92799377 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.42799377 27.3220005 Tm [(ligand)] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.2519989 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.7519989 27.3220005 Tm [(fa)1(mi)-1(ly.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.5 27.3220005 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.76199341 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.26199341 27.3220005 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(ot)1(e)-1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.12199974 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.62199974 42.92200089 Tm [(preferentially)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.50499725 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.00499725 42.92200089 Tm [(induc)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.03399658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.53399658 42.92200089 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 167.52799988 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 172.02799988 42.92200089 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.96899414 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.46899414 42.92200089 Tm [(tr)1(ansfor)1(m)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.52000427 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.02000427 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.29699707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.79699707 42.92200089 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(umor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.13699913 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.63699913 58.52199936 Tm [(ce)-1(lls,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.37900162 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.87900162 58.52199936 Tm [(but)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.52600098 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.02600098 58.52199936 Tm [(do)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.77700043 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.27700043 58.52199936 Tm [(not)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.89800262 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.39800262 58.52199936 Tm [(ap)1(pear)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.38600159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.88600159 58.52199936 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.96099854 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.46099854 58.52199936 Tm [(ki)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.54600525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.04600525 58.52199936 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.55299377 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.05299377 58.52199936 Tm [(ce)-1(lls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.6289978 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 239.1289978 58.52199936 Tm [(alt)1(hou)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(gh)] TJ ET EMC /P <> BDC BT 1 0 0 -1 11.29800034 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.79800034 74.12200165 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.54599953 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.04599953 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.60699844 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.10699844 74.12200165 Tm [(expressed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.26100159 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.76100159 74.12200165 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.08899689 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.58899689 74.12200165 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.56400299 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.06400299 74.12200165 Tm [(significant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.2250061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.7250061 74.12200165 Tm [(leve)-1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.45199585 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.95199585 74.12200165 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.89300537 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.39300537 74.12200165 Tm [(most)] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.06700134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.56700134 74.12200165 Tm [(normal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.07400513 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.57400513 74.12200165 Tm [(tiss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ue)-1(s)1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.98500061 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.48500061 89.72200012 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.74700165 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.24700165 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.55400085 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.05400085 89.72200012 Tm [(binds)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.66600037 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.16600037 89.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.24099731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.74099731 89.72200012 Tm [(seve)-1(r)1(al)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.6499939 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.1499939 89.72200012 Tm [(members)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.58000183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.08000183 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.92199707 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.42199707 89.72200012 Tm [(TNF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.67900085 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.17900085 89.72200012 Tm [(rec)-1(ept)1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 3.43700004 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.9369998 105.3219986 Tm [(superfa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.02099991 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.52099991 105.3219986 Tm [(inc)-1(luding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.3710022 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.8710022 105.3219986 Tm [(TNFRSF)-1(10)-1(A)1(/T)-1(R)1(AILR1,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.66400146 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.16400146 105.3219986 Tm [(TNFRSF)-1(10)-1(B/TR)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(AILR2,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.91699982 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.41699982 120.92199707 Tm [(TNFRSF)-1(10)-1(C/TRA)1(IL)-1(R)1(3)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.89800262 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.39800262 120.92199707 Tm [(TNFRSF)-1(10)-1(D)1(/)-1(TRA)1(ILR4)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.71400452 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.21400452 120.92199707 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.49099731 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.99099731 120.92199707 Tm [(po)1(ssi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(bly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.90699959 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.40699959 136.52200317 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.66400146 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.16400146 136.52200317 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.23899841 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.73899841 136.52200317 Tm [(TNFRSF)-1(11)-1(B/OPG.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.59500122 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.09500122 136.52200317 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.9019928 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.4019928 136.52200317 Tm [(activit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.87399292 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.37399292 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.21600342 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.71600342 136.52200317 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.17199707 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.67199707 136.52200317 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.97900391 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.47900391 136.52200317 Tm [(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.76399994 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.26399994 152.12199402 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.11800003 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.61800003 152.12199402 Tm [(mod)1(u)-1(la)1(ted)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.66100311 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.16100311 152.12199402 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.67299652 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.17299652 152.12199402 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.31700134 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.81700134 152.12199402 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.89199829 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.39199829 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.39300537 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.89300537 152.12199402 Tm [(decoy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.75500488 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.25500488 152.12199402 Tm [(rec)-1(ept)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.84300232 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.34300232 152.12199402 Tm [(TNFRSF)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(10)-1(C/TRAILR3,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.3730011 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 62.8730011 167.72200012 Tm [(TNFRSF)-1(10)-1(D)1(/)-1(TRA)1(ILR4)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.18899536 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.68899536 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.96600342 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.46600342 167.72200012 Tm [(TNFRSF)-1(11)-1(B/OPG)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.15600586 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 257.65600586 167.72200012 Tm [(th)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.32800007 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.82800007 183.32200623 Tm [(cann)-1(o)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.48199844 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.98199844 183.32200623 Tm [(induc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.84500122 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.34500122 183.32200623 Tm [(ap)1(opt)1(osis.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.5059967 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.0059967 183.32200623 Tm [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.81300354 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.31300354 183.32200623 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.45700073 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.95700073 183.32200623 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.79899597 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.29899597 183.32200623 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.75500488 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.25500488 183.32200623 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.56199646 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.06201172 183.32200623 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.13699341 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(its)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.91399956 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.41399956 198.92199707 Tm [(rec)-1(ept)1(ors)] TJ ET EMC /P <> BDC BT 1 0 0 -1 55.0019989 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.5019989 198.92199707 Tm [(ha)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.18399811 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.68399811 198.92199707 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.19100189 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.69100189 198.92199707 Tm [(sho)1(wn)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.77200317 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.27200317 198.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.34700012 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.84700012 198.92199707 Tm [(tr)1(i)-1(g)1(ger)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.08799744 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.58799744 198.92199707 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.58900452 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.08900452 198.92199707 Tm [(activat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.03900146 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.53900146 198.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.38101196 198.92199707 Tm [( )] TJ ET EMC Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 203.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 143.8999939 0.75 m 143.8999939 203.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 203.55000305 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 203.92500305 m 423.17498779 203.92500305 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| 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