%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 132 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 96 l -90 96 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 85 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 247.8500061 0 0 -82.75 0 82.75 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 138.55000305 cm q 1 0 0 1 44 0 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 0 23.67700005 Tm 2 Tr 0 g 0.62857145 w 0 G [<0003>-4<0004>-4<0005>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 71.76399994 23.67700005 Tm 0 Tr [(TNFRS)1(F10B)] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 180.25999451 23.67700005 Tm 2 Tr [<0006>-4<0007>-4<0008>-4<0005>-4<0009>] TJ ET EMC /P <> BDC BT /FAAABG 22 Tf 1 0 0 -1 290.70001221 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000A000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm [<000300040005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 97.125 12.82499981 Tm [(TNFRS)-1(F10B)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 148.17399597 12.82499981 Tm [<00060007000800050009>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 200.67399597 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.92399597 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<000F000B000C000D000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Anti-)-1(TN)1(F)-1(RSF)-1(10)1(B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.15699768 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.53100586 12.82499981 Tm [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 163.30299377 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.67700195 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.9980011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 218.37199402 12.82499981 Tm [(anti)-1(bo)-1(dy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.16799927 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0010>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000C000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(CD262;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.83300018 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.58100128 12.82499981 Tm [(DR5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.8730011 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.6210022 12.82499981 Tm [(KI)1(L)-1(LE)-1(R;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.18800354 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.93600464 12.82499981 Tm [(KI)1(L)-1(LE)-1(R/DR5;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.04100037 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.78900146 12.82499981 Tm [(TRAIL-R2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.78900146 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.5369873 12.82499981 Tm [(TRAILR2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.32299805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.0710144 12.82499981 Tm [(TRICK2;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 330.71899414 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 334.4670105 12.82499981 Tm [(TRICK2A)1(;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 373.19100952 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 376.93899536 12.82499981 Tm [(TRICK2B;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 415.29901123 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [(TRICKB;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.0379982 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.41199875 30.49699783 Tm [(ZT)-1(N)1(F)-1(R9)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.07099915 30.49699783 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 165.35600281 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0011001200130010000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00140005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 198.89500427 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180019>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 134.60800171 12.82499981 Tm [<001C001D>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 155.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 232.43400574 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<001E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<001F000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.36199951 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 265.97299194 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0020000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(TNFRS)-1(F10B)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.4240036 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 299.51199341 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0021002200230024000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.99199677 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 333.05099487 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0025>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0026>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 26.25 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0027000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(Uncon)-1(jugate)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.48899841 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 366.58999634 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 0 g [<0007000800130028000E>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(mou)-1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.77200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.14600372 12.82499981 Tm [(mon)-1(oclo)-1(nal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.46699524 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 48.70299911 Tm /GS2 gs 0 g [<0029002A002B002C>] TJ ET EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 42 48.70299911 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 436.00698853 cm q 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 172.3500061 l 0.375 172.3500061 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 89.72200012 Tm 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 89.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 172.3500061 l 154.7749939 172.3500061 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 173.3500061 l -0.625 173.3500061 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(The)] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.80700016 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.30699921 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 51.61399841 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.11399841 11.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.6210022 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.1210022 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.63300323 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.13300323 11.72200012 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.58900452 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.08900452 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.10499573 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.66600037 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.16600037 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.14100647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.64100647 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.90499878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.40499878 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.24699402 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.74699402 11.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 247.7480011 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.2480011 11.72200012 Tm [(T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(NF-rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.41400146 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.91400146 27.3220005 Tm [(superfa)1(mi)-1(ly,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.16500092 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.66500092 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.94200134 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.44200134 27.3220005 Tm [(contains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.65699768 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.15699768 27.3220005 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.67799377 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.17799377 27.3220005 Tm [(intra)1(c)-1(ell)-1(ular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.64500427 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.14500427 27.3220005 Tm [(de)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(at)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.86900043 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.36899948 42.92200089 Tm [(do)1(main.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.36299896 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.86299896 42.92200089 Tm [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.125 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.625 42.92200089 Tm [(rec)-1(ept)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.04699707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.54699707 42.92200089 Tm [(can)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.58099365 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.08099365 42.92200089 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.93499756 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.43499756 42.92200089 Tm [(activat)1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.58599854 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.08599854 42.92200089 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.5980072 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.0980072 42.92200089 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.58799744 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.08799744 42.92200089 Tm [(ne)-1(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ros)1(i)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.88500023 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.38500023 58.52199936 Tm [(fa)1(c)-1(t)1(or-r)1(e)-1(lat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.52700043 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.02700043 58.52199936 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.02099609 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.52099609 58.52199936 Tm [(induc)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.97599792 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.47599792 58.52199936 Tm [(ligand)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.30000305 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.80000305 58.52199936 Tm [(\(TNFS)-1(F10)-1(/T)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(RA)1(IL)-1(/A)1(PO-2L\),)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.45299911 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.95300293 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.23000336 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.73000336 74.12200165 Tm [(tr)1(ansduc)-1(es)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.29400635 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.79400635 74.12200165 Tm [(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.31500244 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.81500244 74.12200165 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.80900574 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 199.30900574 74.12200165 Tm [(signal.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.70899963 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.20899963 74.12200165 Tm [(Studie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 89.72200012 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.06200027 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.56200027 89.72200012 Tm [(FADD)1(-deficie)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.5719986 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.0719986 89.72200012 Tm [(mic)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.51999664 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.01999664 89.72200012 Tm [(sugg)1(e)-1(st)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.73399353 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 176.23399353 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.45599365 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.95599365 89.72200012 Tm [(FADD)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.94700623 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.44700623 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.42199707 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.92199707 89.72200012 Tm [(deat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.54199982 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.04199982 105.3219986 Tm [(do)1(main)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.86899948 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.36899948 105.3219986 Tm [(containing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.11599731 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.61599731 105.3219986 Tm [(ad)1(apt)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.58099365 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.08099365 105.3219986 Tm [(pro)1(tein)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.55400085 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.05400085 105.3219986 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.61500549 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.11500549 105.3219986 Tm [(required)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.65600586 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.15600586 105.3219986 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 238.43400574 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.93400574 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.93499756 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.99399948 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.49399948 120.92199707 Tm [(mediat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.37599945 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.87599945 120.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.38800049 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.88800049 120.92199707 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.34400177 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.84400177 120.92199707 Tm [(pro)1(tein)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.31700134 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.81700134 120.92199707 Tm [(Two)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.80400085 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.30400085 120.92199707 Tm [(tr)1(ansc)-1(rip)1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.22599792 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.72599792 120.92199707 Tm [(var)1(i)-1(a)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(ts)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.51900005 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.01900005 136.52200317 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.36100006 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.86100006 136.52200317 Tm [(dif)1(fe)-1(r)1(e)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.8010025 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.3010025 136.52200317 Tm [(isof)1(orms)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.46099854 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.96099854 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.23800659 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.73800659 136.52200317 Tm [(one)] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.11199951 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.61199951 136.52200317 Tm [(non-coding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.00799561 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.50799561 136.52200317 Tm [(tr)1(ans)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(cript)] TJ ET EMC /P <> BDC BT 1 0 0 -1 19.44599915 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.94599915 152.12199402 Tm [(ha)1(ve)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.29299927 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.79299927 152.12199402 Tm [(been)] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.30000305 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.80000305 152.12199402 Tm [(fo)1(u)-1(nd)] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.48999786 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.98999786 152.12199402 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.26799774 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.76799774 152.12199402 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.22399902 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.72399902 152.12199402 Tm [(gene)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.40600586 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.90600586 152.12199402 Tm [([pr)1(ovided)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.55700684 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.05700684 152.12199402 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.56900024 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.06900024 152.12199402 Tm [(RefSe)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(q,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 7.92299986 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.42300034 167.72200012 Tm [(Mar)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.62800026 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.12799835 167.72200012 Tm [(20)-1(09)-1(].)] TJ ET EMC /P <> BDC BT 1 0 0 -1 60.41199875 167.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 172.3500061 cm q 1 g 0.375 0.75 m 154.0249939 0.75 l 154.0249939 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 155.0249939 -0.25 l 155.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(Applic)1(ations:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 59.08000183 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 g 154.7749939 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 154.7749939 16.35000038 l h f* Q q 1 0 0 1 154.3999939 0 cm -0.625 -0.25 m 269.0249939 -0.25 l 269.0249939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm 0.13333334 g [(WB,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.97200012 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.47200012 11.72200012 Tm [(IHC)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.09899902 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 188.70001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 0.75 m 154.3999939 172.3500061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 154.3999939 173.1000061 m 154.3999939 188.70001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 188.70001221 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 172.7250061 m 422.42498779 172.7250061 l S Q q 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 189.07501221 m 423.17498779 189.07501221 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>