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1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 75.1210022 23.67700005 Tm 0 g [(C17orf67)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 163.4750061 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 340.1789856 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(C17orf67)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 104.91300201 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 188.91299438 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(C17orf67)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.28800201 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.66200256 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.86399841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.23800659 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.21800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.59199524 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.06599426 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011001200130014000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 15.75 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 36.75 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42 12.82499981 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 57.75 12.82499981 Tm [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 89.25 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 103.10800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 124.10800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001A001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 214.49499512 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(43-11)1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.41799927 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.45300293 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.4940033 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.52900696 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.95999146 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.99499512 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.48800659 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.52301025 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.20901489 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.24398804 12.04500008 Tm [(C17orf67)] TJ ET EMC /P <> BDC BT 1 0 0 -1 344.91900635 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 248.03399658 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<001C001D001E001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 -3.75 281.57299805 cm q /GS2 gs 1 g 0.375 0.75 m 98.72499847 0.75 l 98.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.72499847 -0.25 l 99.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 99.47499847 16.35000038 l h f* Q q 1 0 0 1 99.09999847 0 cm -0.625 -0.25 m 328.07501221 -0.25 l 328.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.79499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.29499817 11.72200012 Tm [(17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.85099792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.35099792 11.72200012 Tm [(op)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.47299957 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.97299957 11.72200012 Tm [(reading)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.94500732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.44500732 11.72200012 Tm [(fra)1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.51600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.01600647 11.72200012 Tm [(67)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.57200623 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 98.72499847 0.75 l 98.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.72499847 -0.25 l 99.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 99.47499847 16.35000038 l h f* Q q 1 0 0 1 99.09999847 0 cm -0.625 -0.25 m 328.07501221 -0.25 l 328.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q0P5)-1(P)1(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.18099976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 98.72499847 0.75 l 98.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.72499847 -0.25 l 99.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 99.47499847 16.35000038 l h f* Q q 1 0 0 1 99.09999847 0 cm -0.625 -0.25 m 328.07501221 -0.25 l 328.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(93)-1(90)-1(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 98.72499847 0.75 l 98.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.72499847 -0.25 l 99.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 99.47499847 16.35000038 l h f* Q q 1 0 0 1 99.09999847 0 cm -0.625 -0.25 m 328.07501221 -0.25 l 328.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 98.72499847 0.75 l 98.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.72499847 -0.25 l 99.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 99.47499847 16.35000038 l h f* Q q 1 0 0 1 99.09999847 0 cm -0.625 -0.25 m 328.07501221 -0.25 l 328.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 98.72499847 0.75 l 98.72499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 99.72499847 -0.25 l 99.72499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.47499847 0.75 m 426.17501831 0.75 l 426.17501831 16.35000038 l 99.47499847 16.35000038 l h f* Q q 1 0 0 1 99.09999847 0 cm -0.625 -0.25 m 328.07501221 -0.25 l 328.07501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 98.72499847 0.75 l 98.72499847 234.75 l 0.375 234.75 l h f* Q q -0.625 -0.25 m 99.72499847 -0.25 l 99.72499847 235.75 l -0.625 235.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 120.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 120.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 99.47499847 0.75 m 426.17501831 0.75 l 426.17501831 234.75 l 99.47499847 234.75 l h f* Q q 1 0 0 1 99.09999847 0 cm -0.625 -0.25 m 328.07501221 -0.25 l 328.07501221 235.75 l -0.625 235.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(C17)-1(or)1(f67)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.40999985 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.90999985 11.72200012 Tm [(\(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 103.71099854 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.21099854 11.72200012 Tm [(17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.76699829 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.26699829 11.72200012 Tm [(op)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.38900757 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.88900757 11.72200012 Tm [(reading)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.86099243 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.36099243 11.72200012 Tm [(fra)1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 212.43200684 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.93200684 11.72200012 Tm [(67)-1(\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.4940033 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.9940033 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.55499268 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.05499268 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.02999878 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.52999878 11.72200012 Tm [(11)-1(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.36300659 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.86300659 11.72200012 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 302.93301392 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.43301392 11.72200012 Tm [(aci)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.75699997 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.25699997 27.3220005 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.56399918 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.06399918 27.3220005 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 63.2859993 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.78600311 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.34700012 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.84700012 27.3220005 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.35399628 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.85399628 27.3220005 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.36599731 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.86599731 27.3220005 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.84100342 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.34100342 27.3220005 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.85699463 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.35699463 27.3220005 Tm [(map)1(ping)] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.95899963 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.45899963 27.3220005 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.53399658 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.03399658 27.3220005 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.07501221 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.57501221 27.3220005 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 319.36999512 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(17)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.72200012 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.22200012 42.92200089 Tm [(Chro)1(mosome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 75.52400208 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.02400208 42.92200089 Tm [(17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.58000183 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.08000183 42.92200089 Tm [(make)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.66000366 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.16000366 42.92200089 Tm [(up)] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.45399475 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.95399475 42.92200089 Tm [(over)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.94299316 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.44299316 42.92200089 Tm [(2.5)-1(%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.17199707 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.67199707 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.51400757 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.01400757 42.92200089 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.01499939 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 223.51499939 42.92200089 Tm [(human)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.55599976 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.05599976 42.92200089 Tm [(genome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.72601318 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 298.22601318 42.92200089 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.62200928 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ab)1(out)] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.34300041 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.84300041 58.52199936 Tm [(81)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.39899826 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.89899826 58.52199936 Tm [(million)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.18000031 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.68000031 58.52199936 Tm [(ba)1(se)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.84100342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.34100342 58.52199936 Tm [(en)-1(cod)1(i)-1(ng)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.68299866 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.18299866 58.52199936 Tm [(over)] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.17199707 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.67199707 58.52199936 Tm [(1,2)-1(00)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.94999695 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.44999695 58.52199936 Tm [(gene)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.29800415 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.79800415 58.52199936 Tm [(Two)] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.78500366 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.28500366 58.52199936 Tm [(ke)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.05499268 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.55499268 58.52199936 Tm [(tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.04501343 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 308.54501343 58.52199936 Tm [(su)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(pp)1(re)-1(s)1(sor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.52899933 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.02899933 74.12200165 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.71099854 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.21099854 74.12200165 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 85.72899628 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 90.22899628 74.12200165 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.35600281 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.85600281 74.12200165 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.2519989 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.7519989 74.12200165 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.54699707 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.04699707 74.12200165 Tm [(17)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.76899719 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.26899719 74.12200165 Tm [(namely)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.6539917 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.1539917 74.12200165 Tm [(p53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 295.45800781 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.95800781 74.12200165 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 316.23498535 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(BRCA1.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.31999969 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.81999969 89.72200012 Tm [(Tumor)] TJ ET EMC /P <> BDC BT 1 0 0 -1 64.11599731 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.61599731 89.72200012 Tm [(supp)1(re)-1(ss)1(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.85700226 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.35700226 89.72200012 Tm [(p53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.66099548 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.16099548 89.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.72200012 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.22200012 89.72200012 Tm [(ne)-1(cessary)] TJ ET EMC /P <> BDC BT 1 0 0 -1 194.00100708 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.50100708 89.72200012 Tm [(fo)1(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.77900696 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.27900696 89.72200012 Tm [(maintenanc)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.77301025 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.27301025 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.11499023 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.61499023 89.72200012 Tm [(ce)-1(llular)] TJ ET EMC /P <> BDC BT 1 0 0 -1 319.37701416 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(gene)-1(t)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.77700043 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.27700043 105.3219986 Tm [(integrit)1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.38200378 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.88200378 105.3219986 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.39399719 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.89399719 105.3219986 Tm [(mod)1(e)-1(ra)1(ting)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.37399292 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.87399292 105.3219986 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.28399658 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.78399658 105.3219986 Tm [(fa)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.33799744 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.83799744 105.3219986 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.73500061 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.23500061 105.3219986 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.74000549 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.24000549 105.3219986 Tm [(repair)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.33700562 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.83700562 105.3219986 Tm [(versus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 307.98199463 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.48199463 105.3219986 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(ell)] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.89599991 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 14.39599991 120.92199707 Tm [(deat)1(h.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.29499817 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.79499817 120.92199707 Tm [(Malfunction)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.6989975 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.1989975 120.92199707 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.35700226 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.85700226 120.92199707 Tm [(loss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.30599976 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.80599976 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.647995 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 150.147995 120.92199707 Tm [(p53)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.45199585 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.95199585 120.92199707 Tm [(expression)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.90600586 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.40600586 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.96699524 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.46699524 120.92199707 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.59399414 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.09399414 120.92199707 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 300.48999023 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.98999023 120.92199707 Tm [(ma)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(lignant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.9659996 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.4659996 136.52200317 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.87599945 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.37599945 136.52200317 Tm [(gr)1(owt)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.29199982 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.79199982 136.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 105.06900024 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.56900024 136.52200317 Tm [(Li-Fraumen)-1(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.69500732 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.19500732 136.52200317 Tm [(syndrome.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.29200745 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 214.79200745 136.52200317 Tm [(Lik)-1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.81199646 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.31199646 136.52200317 Tm [(p53)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.78199768 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.28201294 136.52200317 Tm [(BRCA1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.43499756 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 292.93499756 136.52200317 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.4960022 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 303.9960022 136.52200317 Tm [(dir)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(ec)-1(t)1(l)-1(y)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.13100052 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.63100052 152.12199402 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.5 152.12199402 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.44100189 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 77.94100189 152.12199402 Tm [(DNA)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.44599915 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.94599915 152.12199402 Tm [(repair,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.21000671 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.71000671 152.12199402 Tm [(speci)-1(f)1(ic)-1(ally)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.19500732 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.69500732 152.12199402 Tm [(it)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.44299316 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 195.94299316 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.5039978 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 207.0039978 152.12199402 Tm [(rec)-1(o)1(gnized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.76800537 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.26800537 152.12199402 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.40899658 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.90899658 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.88400269 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.38400269 152.12199402 Tm [(gene)-1(t)1(ic)] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.16101074 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 167.72200012 Tm [(determinant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.00699997 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.50699997 167.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.34899902 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.84899902 167.72200012 Tm [(early)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.52500153 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.02500153 167.72200012 Tm [(onset)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.91799927 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.41799927 167.72200012 Tm [(breast)] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.20300293 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.70300293 167.72200012 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.79299927 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.29299927 167.72200012 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.57000732 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.07000732 167.72200012 Tm [(predisp)1(ositio)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.7250061 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.2250061 167.72200012 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 284.29998779 167.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.79998779 167.72200012 Tm [(canc)-1(er)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 183.32200623 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 4.16599989 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 8.66600037 183.32200623 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.50799942 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.00799942 183.32200623 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.00899887 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.50899887 183.32200623 Tm [(ova)1(ry)-1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.29599762 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 70.79599762 183.32200623 Tm [(colon,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 96.86000061 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.36000061 183.32200623 Tm [(pro)1(sta)1(te)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.21899414 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.71899414 183.32200623 Tm [(gla)1(n)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.147995 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.647995 183.32200623 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.92500305 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.42500305 183.32200623 Tm [(fa)1(l)-1(lo)1(pian)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.69500732 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.19500732 183.32200623 Tm [(tub)1(e)-1(s.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.28100586 183.32200623 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.78100586 183.32200623 Tm [(Chro)1(mosom)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 198.92199707 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 5.10599995 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 9.60599995 198.92199707 Tm [(17)] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.16200066 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.66200066 198.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.22299957 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 35.72299957 198.92199707 Tm [(also)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.97999954 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 57.47999954 198.92199707 Tm [(link)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.57900238 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.07900238 198.92199707 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.15399933 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 101.65399933 198.92199707 Tm [(ne)-1(uro)1(fibro)1(mato)1(sis,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 182.80799866 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.30799866 198.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.28300476 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.78300476 198.92199707 Tm [(condition)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.73100281 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.23100281 198.92199707 Tm [(chara)1(c)-1(terized)] TJ ET EMC /P <> BDC BT 1 0 0 -1 299.76400757 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 304.26400757 198.92199707 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 314.77600098 198.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 214.52200317 Tm [(ne)-1(ura)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.00399971 214.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.50399971 214.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.78099823 214.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.28099823 214.52200317 Tm [(epidermal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.63300323 214.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.13300323 214.52200317 Tm [(lesi)-1(o)1(ns,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 131.79600525 214.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 136.29600525 214.52200317 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 152.57299805 214.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 157.07299805 214.52200317 Tm [(dysregulat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 213.19099426 214.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.69099426 214.52200317 Tm [(Sc)-1(h)1(wann)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.11199951 214.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.61199951 214.52200317 Tm [(ce)-1(ll)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.02200317 214.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 279.52200317 214.52200317 Tm [(gr)1(owt)1(h.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 312.60400391 214.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 230.12199402 Tm [(Alexander)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.2159996 230.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.7159996 230.12199402 Tm [(disease,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.55400085 230.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.05400085 230.12199402 Tm [(Bi)-1(r)1(t-Hog)1(g-D)1(u)-1(b)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.125 230.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.625 230.12199402 Tm [(syndrome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.55499268 230.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.05499268 230.12199402 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.33200073 230.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.83200073 230.12199402 Tm [(Canava)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 265.5920105 230.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 270.0920105 230.12199402 Tm [(disease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 301.76300049 230.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 306.26300049 230.12199402 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 319.78100586 230.12199402 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 332.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 99.09999847 0.75 m 99.09999847 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 99.09999847 17.10000038 m 99.09999847 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 99.09999847 33.45000076 m 99.09999847 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 99.09999847 49.80000305 m 99.09999847 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 99.09999847 66.15000153 m 99.09999847 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 99.09999847 82.5 m 99.09999847 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 99.09999847 98.84999847 m 99.09999847 332.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.55001831 0.75 m 426.55001831 332.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 333.2250061 m 426.92501831 333.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm
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