%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 116 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 75.1210022 23.67700005 Tm 0 g [(C15orf40)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 163.4750061 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 340.1789856 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm [(C15orf40)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.28800201 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 107.53800201 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 191.53799438 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(C15orf40)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.28800201 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 104.66200256 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.86399841 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.23800659 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.21800232 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.59199524 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.06599426 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [(chromos)-1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.33499908 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.70899963 12.82499981 Tm [(15)] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.35299683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.727005 12.82499981 Tm [(op)-1(e)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.52200317 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.89599609 12.82499981 Tm [(re)1(ad)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.19599915 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.57000732 12.82499981 Tm [(frame)] TJ ET EMC /P <> BDC BT 1 0 0 -1 219.07699585 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.45100403 12.82499981 Tm [(40)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.09500122 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012001300140011000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 105 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0015>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 31.5 12.82499981 Tm [<0016000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 63 12.82499981 Tm /GS2 gs 0 g [<001700180005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 94.5 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 108.35800171 12.82499981 Tm [<0019000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 129.35800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.60800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q /GS2 gs 1 g -1.45000005 214.49499512 m 416.75 214.49499512 l 416.75 245.69499207 l -1.45000005 245.69499207 l h f* Q q 1 0 0 1 0 214.49499512 cm /P <> BDC q /GS2 gs 1 g 0 6.59399986 m 21 6.59399986 l 21 24.60499954 l 0 24.60499954 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 20.17499924 Tm /GS2 gs 0.13333334 g [<00030004>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 21 20.17499924 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 245.69500732 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 273.63400269 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 1.5 l -0.75 1.5 l h W n q 0 1 -1 0 421.19998169 -4.9000001 cm q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(F)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 29.98399925 Tm [(u)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 47.92299652 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 65.86199951 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 83.80099487 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 101.73999786 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 119.67900085 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 137.61799622 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 155.55699158 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 173.4960022 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 191.43499756 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 209.37399292 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 227.31300354 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 245.2519989 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 263.19100952 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 281.13000488 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 299.06900024 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 317.00802612 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 334.94702148 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 352.88601685 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 370.82501221 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 388.76400757 Tm [(p)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 406.70300293 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 424.64199829 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 442.58102417 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 460.52001953 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 478.45901489 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 496.39801025 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 514.3369751 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 532.27600098 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 550.21496582 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 568.1539917 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 586.09295654 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 604.03198242 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 621.9710083 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 639.90997314 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 657.84899902 Tm [(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 675.78796387 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 693.72698975 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 711.66595459 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 729.60498047 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 747.54400635 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 765.48297119 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 783.42199707 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 801.36096191 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 819.29998779 Tm [(v)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 837.23895264 Tm [(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 855.17797852 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 873.11700439 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 891.05596924 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 908.99499512 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 926.93395996 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 944.87298584 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 962.81201172 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 980.75097656 Tm [(2)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 998.69000244 Tm [(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1016.62896729 Tm [(-)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1034.56799316 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1052.50708008 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1070.44604492 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1088.38500977 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1106.32409668 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1124.26306152 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1142.20202637 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1160.14099121 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1178.08007813 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1196.01904297 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1213.95800781 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1231.89709473 Tm [(c)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1249.83605957 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1267.77502441 Tm [(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1285.71398926 Tm [(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1303.65307617 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1321.59204102 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1339.53100586 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1357.47009277 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1375.40905762 Tm [(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1393.34802246 Tm [(u)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1411.2869873 Tm [(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1429.22607422 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1447.16503906 Tm [(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1465.10400391 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1483.04309082 Tm [(C)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1500.98205566 Tm [(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1518.92102051 Tm [(5)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1536.85998535 Tm [(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1554.79907227 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1572.73803711 Tm [(f)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1590.67700195 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 1608.61608887 Tm [(0)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 4.5619998 1608.61608887 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 0.5 w 0 0.5 m 0 0.5 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 0.5 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 0.75 m 426.3500061 0.75 l S Q Q q /GS2 gs 1 g -1.45000005 274.63400269 m 416.75 274.63400269 l 416.75 305.83401489 l -1.45000005 305.83401489 l h f* Q q /GS2 gs 1 g -1.45000005 305.83401489 m 416.75 305.83401489 l 416.75 337.0340271 l -1.45000005 337.0340271 l h f* Q q 1 0 0 1 0 274.63400269 cm /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 0 20.17499924 Tm [( )] TJ ET EMC /P <> BDC q /GS2 gs 1 g 0 37.79399872 m 42 37.79399872 l 42 55.80500031 l 0 55.80500031 l h f* Q EMC /P <> BDC BT /FAAACF 10.5 Tf 1 0 0 -1 0 51.375 Tm /GS2 gs 0.13333334 g [<0005000600070008>] TJ ET EMC /P <> BDC BT /FAAACJ 10.5 Tf 1 0 0 -1 42 51.375 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 337.03399658 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 364.97299194 cm q /GS2 gs 1 g 0.375 0.75 m 120.27500153 0.75 l 120.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.27500153 -0.25 l 121.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.02500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.02500153 16.35000038 l h f* Q q 1 0 0 1 120.65000153 0 cm -0.625 -0.25 m 302.7749939 -0.25 l 302.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.79499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.29499817 11.72200012 Tm [(15)] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.85099792 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.35099792 11.72200012 Tm [(op)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 98.47299957 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.97299957 11.72200012 Tm [(reading)] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.94500732 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.44500732 11.72200012 Tm [(fra)1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.51600647 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.01600647 11.72200012 Tm [(40)] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.57200623 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 120.27500153 0.75 l 120.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.27500153 -0.25 l 121.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.02500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.02500153 16.35000038 l h f* Q q 1 0 0 1 120.65000153 0 cm -0.625 -0.25 m 302.7749939 -0.25 l 302.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q8WUR)1(7)] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.64300156 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 120.27500153 0.75 l 120.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.27500153 -0.25 l 121.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.02500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.02500153 16.35000038 l h f* Q q 1 0 0 1 120.65000153 0 cm -0.625 -0.25 m 302.7749939 -0.25 l 302.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(19)-1(82)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 120.27500153 0.75 l 120.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.27500153 -0.25 l 121.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.02500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.02500153 16.35000038 l h f* Q q 1 0 0 1 120.65000153 0 cm -0.625 -0.25 m 302.7749939 -0.25 l 302.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 120.27500153 0.75 l 120.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.27500153 -0.25 l 121.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.02500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.02500153 16.35000038 l h f* Q q 1 0 0 1 120.65000153 0 cm -0.625 -0.25 m 302.7749939 -0.25 l 302.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 120.27500153 0.75 l 120.27500153 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 121.27500153 -0.25 l 121.27500153 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.02500153 0.75 m 422.42498779 0.75 l 422.42498779 16.35000038 l 121.02500153 16.35000038 l h f* Q q 1 0 0 1 120.65000153 0 cm -0.625 -0.25 m 302.7749939 -0.25 l 302.7749939 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 120.27500153 0.75 l 120.27500153 156.75 l 0.375 156.75 l h f* Q q -0.625 -0.25 m 121.27500153 -0.25 l 121.27500153 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACJ 9 Tf 1 0 0 -1 0 81.92199707 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 57.29199982 81.92199707 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 121.02500153 0.75 m 422.42498779 0.75 l 422.42498779 156.75 l 121.02500153 156.75 l h f* Q q 1 0 0 1 120.65000153 0 cm -0.625 -0.25 m 302.7749939 -0.25 l 302.7749939 157.75 l -0.625 157.75 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAADC 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Encoding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.18399811 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.68399811 11.72200012 Tm [(more)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.38200378 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.88200378 11.72200012 Tm [(th)1(an)] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.29699707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.79699707 11.72200012 Tm [(70)-1(0)] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.62999725 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.12999725 11.72200012 Tm [(gene)-1(s,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.97799683 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 148.47799683 11.72200012 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.272995 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.772995 11.72200012 Tm [(15)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.32899475 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.82899475 11.72200012 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.38999939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.88999939 11.72200012 Tm [(mad)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.16101074 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.66101074 11.72200012 Tm [(up)] TJ ET EMC /P <> BDC BT 1 0 0 -1 275.95498657 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.45498657 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 289.29699707 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(ap)1(prox)1(i)-1(ma)1(tely)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.61100006 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.11100006 27.3220005 Tm [(10)-1(6)] TJ ET EMC /P <> BDC BT 1 0 0 -1 81.94400024 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.44400024 27.3220005 Tm [(million)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.72499847 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.22499847 27.3220005 Tm [(ba)1(se)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.22000122 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 144.72000122 27.3220005 Tm [(pa)1(i)-1(r)1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.44000244 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.94000244 27.3220005 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.21699524 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.71699524 27.3220005 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.27799988 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 201.77799988 27.3220005 Tm [(ab)1(out)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.1210022 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 231.6210022 27.3220005 Tm [(3%)] TJ ET EMC /P <> BDC BT 1 0 0 -1 244.90600586 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.40600586 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.24798584 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 262.74798584 27.3220005 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.74899292 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.24899292 27.3220005 Tm [(hu)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.95400047 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.45400047 42.92200089 Tm [(genome.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.29100037 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.79100037 42.92200089 Tm [(Ang)1(e)-1(lman)] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.8809967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.3809967 42.92200089 Tm [(and)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.65800476 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.15800476 42.92200089 Tm [(Pra)1(der-W)1(i)-1(lli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.00700378 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 190.50700378 42.92200089 Tm [(syndromes)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.60299683 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.10299683 42.92200089 Tm [(are)] TJ ET EMC /P <> BDC BT 1 0 0 -1 255.6210022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.1210022 42.92200089 Tm [(asso)1(c)-1(iat)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 10.86299992 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 15.36299992 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.75899887 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.25899887 58.52199936 Tm [(loss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.70800018 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.20800018 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 68.05000305 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.55000305 58.52199936 Tm [(func)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.29100037 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.79100037 58.52199936 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.9489975 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.4489975 58.52199936 Tm [(dele)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.82899475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.32899475 58.52199936 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.17100525 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.67100525 58.52199936 Tm [(gene)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.35299683 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 209.85299683 58.52199936 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 217.79400635 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.29400635 58.52199936 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.29499817 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.79499817 58.52199936 Tm [(15)-1(q)1(1)-1(1-q13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.86898804 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(region.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 30.12899971 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.62900162 74.12200165 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.81999969 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.31999969 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.32099915 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 65.82099915 74.12200165 Tm [(case)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.58100128 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 89.08100128 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.92299652 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.42299652 74.12200165 Tm [(Ang)1(e)-1(lman)] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.51300049 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.01300049 74.12200165 Tm [(syndrome,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.11000061 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.61000061 74.12200165 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.06599426 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.56599426 74.12200165 Tm [(loss)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.01499939 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.51499939 74.12200165 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 248.07600403 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 252.57600403 74.12200165 Tm [(due)] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.98498535 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.48498535 74.12200165 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.55999756 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.05999756 74.12200165 Tm [(i)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(nactivity)] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.01800156 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 40.51800156 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.36000061 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.86000061 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.86100006 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 72.36100006 89.72200012 Tm [(mat)1(e)-1(rna)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.58000183 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.08000183 89.72200012 Tm [(15)-1(q)1(1)-1(1-q13)] TJ ET EMC /P <> BDC BT 1 0 0 -1 162.15400696 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.65400696 89.72200012 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 204.16099548 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 208.66099548 89.72200012 Tm [(UBE3A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.58599854 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.08599854 89.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.60198975 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 268.10198975 89.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.04299927 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 280.54299927 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 294.54400635 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(bra)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.10000038 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 26.60000038 105.3219986 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 37.11199951 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.61199951 105.3219986 Tm [(either)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.5510025 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.0510025 105.3219986 Tm [(chromos)1(omal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.10899353 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.60899353 105.3219986 Tm [(dele)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 169.98899841 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.48899841 105.3219986 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.64700317 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.14700317 105.3219986 Tm [(mutat)1(ion.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.63600159 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 234.13600159 105.3219986 Tm [(In)] TJ ET EMC /P <> BDC BT 1 0 0 -1 242.32699585 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 246.82699585 105.3219986 Tm [(cases)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.75299072 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 274.25299072 105.3219986 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.09500122 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 287.59500122 105.3219986 Tm [(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 120.92199707 Tm [(rad)1(e)-1(r)1(-Willi)] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.3429985 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.8429985 120.92199707 Tm [(syndrome,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.94000244 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.44000244 120.92199707 Tm [(th)1(e)-1(r)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 121.98400116 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.48400116 120.92199707 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.04499817 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 137.54499817 120.92199707 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 142.52000427 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.02000427 120.92199707 Tm [(pa)1(rtial)] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.29699707 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.79699707 120.92199707 Tm [(or)] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.95500183 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.45500183 120.92199707 Tm [(complete)] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.83200073 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 237.33200073 120.92199707 Tm [(dele)-1(t)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 272.71200562 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.21200562 120.92199707 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.0539856 120.92199707 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 290.5539856 120.92199707 Tm [(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 136.52200317 Tm [(his)] TJ ET EMC /P <> BDC BT 1 0 0 -1 12.10299969 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.60300064 136.52200317 Tm [(region)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.56499863 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 49.06499863 136.52200317 Tm [(fro)1(m)] TJ ET EMC /P <> BDC BT 1 0 0 -1 69.77600098 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.27600098 136.52200317 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.27700043 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.77700043 136.52200317 Tm [(pa)1(ternal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.31100464 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 132.81100464 136.52200317 Tm [(copy)] TJ ET EMC /P <> BDC BT 1 0 0 -1 153.55799866 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.05799866 136.52200317 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.8999939 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 171.3999939 136.52200317 Tm [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.19500732 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.69500732 136.52200317 Tm [(15)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.41700745 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 249.91700745 136.52200317 Tm [(Tay-Sachs)] TJ ET EMC /P <> BDC BT 1 0 0 -1 293.09799194 136.52200317 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 152.12199402 Tm [(disease)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.67099953 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.17100143 152.12199402 Tm [(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 42.73199844 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.23199844 152.12199402 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.20700073 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.70700073 152.12199402 Tm [(lethal)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.47299957 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.97299957 152.12199402 Tm [(diso)1(rder)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.74900055 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.24900055 152.12199402 Tm [(asso)1(c)-1(iat)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 170.37600708 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 174.87600708 152.12199402 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.27200317 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.77200317 152.12199402 Tm [(mutat)1(ions)] TJ ET EMC /P <> BDC BT 1 0 0 -1 241.25999451 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.75999451 152.12199402 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 254.602005 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.10198975 152.12199402 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.10299683 152.12199402 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.60299683 152.12199402 Tm [(HE)] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 254.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.65000153 0.75 m 120.65000153 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.65000153 17.10000038 m 120.65000153 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.65000153 33.45000076 m 120.65000153 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.65000153 49.80000305 m 120.65000153 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.65000153 66.15000153 m 120.65000153 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.65000153 82.5 m 120.65000153 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 120.65000153 98.84999847 m 120.65000153 254.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.79998779 0.75 m 422.79998779 254.8500061 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 255.2250061 m 423.17498779 255.2250061 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>