%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 115 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 86.96399689 23.67700005 Tm 0 g [(C4BPB)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 151.63200378 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 328.33599854 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(C4BPB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.26799774 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 85.51799774 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 169.51800537 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(C4BPB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.26799774 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.64199829 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.84400177 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.21800232 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.19799805 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 180.57200623 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.04600525 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [(compl)-1(e)1(ment)] TJ ET EMC /P <> BDC BT 1 0 0 -1 106.66100311 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.03500366 12.82499981 Tm [(compo)-1(nent)] TJ ET EMC /P <> BDC BT 1 0 0 -1 158.22799683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.602005 12.82499981 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.92399597 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 168.29800415 12.82499981 Tm [(bi)-1(nd)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.12600708 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.5 12.82499981 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.88200378 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 236.2559967 12.82499981 Tm [(beta;)] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.35299683 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.72698975 12.82499981 Tm [(C4BP)] TJ ET EMC /P <> BDC BT 1 0 0 -1 282.7829895 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 97.85800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 118.85800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 208.89500427 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 236.83399963 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 282.71200562 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(21-25)1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 226.41799927 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.45300293 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 251.4940033 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 253.52900696 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 271.95999146 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.99499512 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.48800659 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 283.52301025 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 309.20901489 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 311.24398804 12.04500008 Tm [(C4BPB)] TJ ET EMC /P <> BDC BT 1 0 0 -1 335.04501343 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 311.65100098 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 339.58999634 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 385.46798706 cm q /GS2 gs 1 g 0.375 0.75 m 136.875 0.75 l 136.875 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.875 -0.25 l 137.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.625 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.625 16.35000038 l h f* Q q 1 0 0 1 137.25 0 cm -0.625 -0.25 m 289.92498779 -0.25 l 289.92498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(compleme)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.35599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 58.85599899 11.72200012 Tm [(component)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.54499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.04499817 11.72200012 Tm [(4)] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.32299805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.82299805 11.72200012 Tm [(binding)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.96699524 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.46699524 11.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 191.77400208 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 196.27400208 11.72200012 Tm [(beta)] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.45599365 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 136.875 0.75 l 136.875 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.875 -0.25 l 137.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Synonyms:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 49.17900085 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.625 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.625 16.35000038 l h f* Q q 1 0 0 1 137.25 0 cm -0.625 -0.25 m 289.92498779 -0.25 l 289.92498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(C4B)-1(P)] TJ ET EMC /P <> BDC BT 1 0 0 -1 22.45199966 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 136.875 0.75 l 136.875 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.875 -0.25 l 137.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.625 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.625 16.35000038 l h f* Q q 1 0 0 1 137.25 0 cm -0.625 -0.25 m 289.92498779 -0.25 l 289.92498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(P20)-1(85)-1(1)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.89599991 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 136.875 0.75 l 136.875 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.875 -0.25 l 137.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.625 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.625 16.35000038 l h f* Q q 1 0 0 1 137.25 0 cm -0.625 -0.25 m 289.92498779 -0.25 l 289.92498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(05)-1(37)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 136.875 0.75 l 136.875 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.875 -0.25 l 137.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.625 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.625 16.35000038 l h f* Q q 1 0 0 1 137.25 0 cm -0.625 -0.25 m 289.92498779 -0.25 l 289.92498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 136.875 0.75 l 136.875 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.875 -0.25 l 137.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.625 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.625 16.35000038 l h f* Q q 1 0 0 1 137.25 0 cm -0.625 -0.25 m 289.92498779 -0.25 l 289.92498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 136.875 0.75 l 136.875 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 137.875 -0.25 l 137.875 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.625 0.75 m 426.17498779 0.75 l 426.17498779 16.35000038 l 137.625 16.35000038 l h f* Q q 1 0 0 1 137.25 0 cm -0.625 -0.25 m 289.92498779 -0.25 l 289.92498779 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 114.44999695 cm q /GS2 gs 1 g 0.375 0.75 m 136.875 0.75 l 136.875 109.94999695 l 0.375 109.94999695 l h f* Q q -0.625 -0.25 m 137.875 -0.25 l 137.875 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 58.52199936 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 58.52199936 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 137.625 0.75 m 426.17498779 0.75 l 426.17498779 109.94999695 l 137.625 109.94999695 l h f* Q q 1 0 0 1 137.25 0 cm -0.625 -0.25 m 289.92498779 -0.25 l 289.92498779 110.94999695 l -0.625 110.94999695 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(This)] TJ ET EMC /P <> BDC BT 1 0 0 -1 17.26199913 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 21.76199913 11.72200012 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.27799988 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.77799988 11.72200012 Tm [(en)-1(cod)1(e)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 83.69499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.19499969 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.16999817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.66999817 11.72200012 Tm [(member)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.93400574 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.43400574 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 147.27600098 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.77600098 11.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 156.75100708 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.25100708 11.72200012 Tm [(superfa)1(mi)-1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 211.33500671 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 215.83500671 11.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.67700195 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 229.17700195 11.72200012 Tm [(pro)1(tein)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.6499939 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.1499939 11.72200012 Tm [(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 27.3220005 Tm [(mpo)1(se)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 34.93199921 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 39.43199921 27.3220005 Tm [(predo)1(min)-1(a)1(n)-1(t)1(ly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 102.60800171 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.10800171 27.3220005 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.94999695 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.44999695 27.3220005 Tm [(ta)1(n)-1(d)1(e)-1(mly)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.77900696 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 165.27900696 27.3220005 Tm [(arr)1(aye)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.72799683 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 202.22799683 27.3220005 Tm [(sho)1(rt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 224.44700623 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 228.94700623 27.3220005 Tm [(conse)-1(nsus)] TJ ET EMC /P <> BDC BT 1 0 0 -1 273.42401123 27.3220005 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 277.92401123 27.3220005 Tm [(r)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 42.92200089 Tm [(epeats)] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.45499992 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.95500183 42.92200089 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.79700089 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 46.29700089 42.92200089 Tm [(ap)1(prox)1(i)-1(ma)1(tely)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.90799713 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 112.40799713 42.92200089 Tm [(60)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.96399689 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 127.46399689 42.92200089 Tm [(amino)] TJ ET EMC /P <> BDC BT 1 0 0 -1 154.53399658 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.03399658 42.92200089 Tm [(acids.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.0059967 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 187.5059967 42.92200089 Tm [(A)] TJ ET EMC /P <> BDC BT 1 0 0 -1 193.83900452 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.33900452 42.92200089 Tm [(single,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.8710022 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.3710022 42.92200089 Tm [(uni)-1(q)1(ue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 260.26699829 42.92200089 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.76699829 42.92200089 Tm [(bet)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 58.52199936 Tm [(a-)1(c)-1(ha)1(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.83799934 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.33800125 58.52199936 Tm [(en)-1(cod)1(e)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 73.84500122 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 78.34500122 58.52199936 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.85700226 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.35700226 58.52199936 Tm [(th)1(is)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.81300354 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 113.31300354 58.52199936 Tm [(gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 134.82899475 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 139.32899475 58.52199936 Tm [(assembles)] TJ ET EMC /P <> BDC BT 1 0 0 -1 183.59100342 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 188.09100342 58.52199936 Tm [(wit)1(h)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.48699951 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.98699951 58.52199936 Tm [(seve)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 235.63600159 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.13600159 58.52199936 Tm [(identical)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.5710144 58.52199936 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 74.12200165 Tm [(alph)1(a-chains)] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.66400146 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 59.16400146 74.12200165 Tm [(into)] TJ ET EMC /P <> BDC BT 1 0 0 -1 76.18000031 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 80.68000031 74.12200165 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 94.68099976 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 99.18099976 74.12200165 Tm [(predo)1(min)-1(a)1(n)-1(t)] TJ ET EMC /P <> BDC BT 1 0 0 -1 155.19799805 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 159.69799805 74.12200165 Tm [(isof)1(orm)] TJ ET EMC /P <> BDC BT 1 0 0 -1 192.69200134 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 197.19200134 74.12200165 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 206.03399658 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 210.53399658 74.12200165 Tm [(C4b-b)1(in)-1(d)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 264.61700439 74.12200165 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.11700439 74.12200165 Tm [(pr)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 89.72200012 Tm [(ot)1(e)-1(in,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 24.28899956 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 28.78899956 89.72200012 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.76399994 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.26399994 89.72200012 Tm [(multimeric)] TJ ET EMC /P <> BDC BT 1 0 0 -1 84.26999664 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.76999664 89.72200012 Tm [(pro)1(tein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 120.07700348 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.57700348 89.72200012 Tm [(th)1(at)] TJ ET EMC /P <> BDC BT 1 0 0 -1 141.79899597 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 146.29899597 89.72200012 Tm [(controls)] TJ ET EMC /P <> BDC BT 1 0 0 -1 181.1519928 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.6519928 89.72200012 Tm [(activat)1(ion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.602005 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 232.102005 89.72200012 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 240.94400024 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 245.44400024 89.72200012 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 259.44500732 89.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 263.94500732 89.72200012 Tm [(co)] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 105.3219986 Tm [(mpleme)-1(nt)] TJ ET EMC /P <> BDC BT 1 0 0 -1 44.12099838 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.62099838 105.3219986 Tm [(casc)-1(a)1(de)] TJ ET EMC /P <> BDC BT 1 0 0 -1 82.62599945 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.12599945 105.3219986 Tm [(th)1(rough)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.02300262 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 126.52300262 105.3219986 Tm [(th)1(e)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.52400208 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 145.02400208 105.3219986 Tm [(cl)-1(a)1(ssic)-1(a)1(l)] TJ ET EMC /P <> BDC BT 1 0 0 -1 179.51699829 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.01699829 105.3219986 Tm [(pa)1(thw)1(ay.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 222.64500427 105.3219986 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 227.14500427 105.3219986 Tm [(C4b-b)1(in)-1(d)1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 281.22799683 105.3219986 Tm [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.25 0.75 m 137.25 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.25 17.10000038 m 137.25 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.25 33.45000076 m 137.25 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.25 49.80000305 m 137.25 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.25 66.15000153 m 137.25 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.25 82.5 m 137.25 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.25 98.84999847 m 137.25 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 137.25 115.19999695 m 137.25 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 426.54998779 0.75 m 426.54998779 224.3999939 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 426.92498779 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 426.17498779 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 426.17498779 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 426.17498779 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 426.17498779 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 426.17498779 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 426.17498779 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 114.82499695 m 426.17498779 114.82499695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 224.7749939 m 426.92498779 224.7749939 l S Q Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>