%PDF-1.5 %ÈÈÈÈÈÈ?1 0 obj <> endobj 2 0 obj <>/Metadata 103 0 R>> endobj 3 0 obj <> endobj 4 0 obj <>/ExtGState<>/XObject<>>>/Group<>/StructParents 0/Tabs/S>> endobj 5 0 obj <>stream 1 0 0 -1 0 841.90002441 cm /Artifact <> BDC q 1 0 0 1 90 42.54999924 cm -90 0 m 505.29998779 0 l 505.29998779 103.5 l -90 103.5 l h W n BT /FAAAAH 9 Tf 1 0 0 -1 0 92.5 Tm 0 g [( )] TJ ET q 1 0 0 1 9 1 cm q 270.1000061 0 0 -90.15000153 0 90.15000153 cm /X1 Do Q Q Q EMC q 1 0 0 1 90 146.05000305 cm /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 80.69599915 23.67700005 Tm 0 g [(C3orf)-1(3)1(8)] TJ ET EMC /P <> BDC BT /FAAABE 22 Tf 1 0 0 -1 157.8999939 23.67700005 Tm 2 Tr 0.62857145 w 0 G [<0003>-4<0004>-4<0005>-4<0006>-4<0007>-4<0008>-4<0009>-4<000A>] TJ ET EMC /P <> BDC BT /FAAABB 22 Tf 1 0 0 -1 334.60400391 23.67700005 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC q 1 0 0 1 0 46.79999924 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<000B000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(C3orf38)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.46600342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 91.71600342 12.82499981 Tm [<0003000400050006000700080009000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 175.71600342 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 80.33899689 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0010000C000D000E000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [(C3orf38)] TJ ET EMC /P <> BDC BT 1 0 0 -1 86.46600342 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.83999634 12.82499981 Tm [(Antigen)] TJ ET EMC /P <> BDC BT 1 0 0 -1 122.04199982 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 124.41600037 12.82499981 Tm [(\(Recombi)-1(nant)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.39599609 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 186.77000427 12.82499981 Tm [(Pr)1(o)-1(te)1(i)-1(n\))] TJ ET EMC /P <> BDC BT 1 0 0 -1 221.2440033 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 113.87799835 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0011>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<000D000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.5 12.82499981 Tm [(chromos)-1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 108.83499908 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 111.20899963 12.82499981 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 116.53099823 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 118.90499878 12.82499981 Tm [(op)-1(e)1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 140.69999695 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 143.07400513 12.82499981 Tm [(re)1(ad)-1(ing)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.37399292 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 177.7480011 12.82499981 Tm [(frame)] TJ ET EMC /P <> BDC BT 1 0 0 -1 203.25500488 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 205.6289978 12.82499981 Tm [(38)] TJ ET EMC /P <> BDC BT 1 0 0 -1 216.272995 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 147.41700745 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0012>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 10.5 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 21 12.82499981 Tm [<0013000F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 52.5 12.82499981 Tm [<001400150005>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 84 12.82499981 Tm [(-20)] TJ ET EMC /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 97.85800171 12.82499981 Tm [<0016000A>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 118.85800171 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 129.35800171 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 180.95599365 cm /P <> BDC BT /FAAABJ 10.5 Tf 1 0 0 -1 0 12.82499981 Tm /GS2 gs 0 g [<0017001800190011000F00030004>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 73.5 12.82499981 Tm /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 84 12.82499981 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 0 48.43599701 Tm /GS2 gs 0 g [( )] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 2.37400007 48.43599701 Tm /GS1 gs 0 g [( )] TJ ET EMC Q q 1 0 0 1 0 244.772995 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001A>-4<001B>] TJ ET EMC /P <> BDC BT /FAAABB 10.5 Tf 1 0 0 -1 21.08399963 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 -5.4000001 290.65100098 cm q -0.75 -0.5 m 426.8500061 -0.5 l 426.8500061 29.43899918 l -0.75 29.43899918 l h W n q 1 0 0 1 5.4000001 0.5 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm /GS2 gs 0 g [(Fu)-1(sio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.92399979 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 25.95899963 12.04500008 Tm [(protein)] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.85800171 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 54.89300156 12.04500008 Tm [(corr)1(esp)-1(ond)-1(in)-1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 107.68000031 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 109.71499634 12.04500008 Tm [(to)] TJ ET EMC /P <> BDC BT 1 0 0 -1 117.47599792 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 119.51100159 12.04500008 Tm [(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 123.8219986 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 125.85700226 12.04500008 Tm [(re)1(gio)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 149.24899292 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 151.28399658 12.04500008 Tm [(derive)1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 178.96499634 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 181 12.04500008 Tm [(from)] TJ ET EMC /P <> BDC BT 1 0 0 -1 198.82000732 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 200.85499573 12.04500008 Tm [(130-3)1(29)] TJ ET EMC /P <> BDC BT 1 0 0 -1 230.97999573 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 233.01499939 12.04500008 Tm [(amin)-1(o)] TJ ET EMC /P <> BDC BT 1 0 0 -1 256.05599976 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 258.09100342 12.04500008 Tm [(acid)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 276.52200317 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 278.55700684 12.04500008 Tm [(of)] TJ ET EMC /P <> BDC BT 1 0 0 -1 286.04998779 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 288.08499146 12.04500008 Tm [(hu)-1(man)] TJ ET EMC /P <> BDC BT 1 0 0 -1 313.77099609 12.04500008 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 315.80599976 12.04500008 Tm [(C3orf38)] TJ ET EMC /P <> BDC BT 1 0 0 -1 344.92001343 12.04500008 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 0.5 w 0 0.5 m 0 28.43899918 l S Q q 0.5 w 426.1000061 0.5 m 426.1000061 28.43899918 l S Q q 0.5 w -0.25 0.25 m 426.3500061 0.25 l S Q q 0.5 w -0.25 28.68899918 m 426.3500061 28.68899918 l S Q Q q 1 0 0 1 0 319.58999634 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 347.5289917 cm /P <> BDC BT /FAAABE 10.5 Tf 1 0 0 -1 0 12.82499981 Tm 2 Tr /GS2 gs 0 g 0.30000001 w [<001C>-4<001D>-4<001E>-4<001F>] TJ ET EMC /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 42.16799927 12.82499981 Tm 0 Tr /GS1 gs 0 g [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 0 30.49699783 Tm [( )] TJ ET EMC Q q 1 0 0 1 -3.75 393.40701294 cm q /GS2 gs 1 g 0.375 0.75 m 107.22499847 0.75 l 107.22499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.22499847 -0.25 l 108.22499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Full)] TJ ET EMC /P <> BDC BT 1 0 0 -1 16.18099976 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 20.68099976 11.72200012 Tm [(name:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 48.35800171 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.97499847 0.75 m 422.42501831 0.75 l 422.42501831 16.35000038 l 107.97499847 16.35000038 l h f* Q q 1 0 0 1 107.59999847 0 cm -0.625 -0.25 m 315.82501221 -0.25 l 315.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(chromos)1(ome)] TJ ET EMC /P <> BDC BT 1 0 0 -1 56.79499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 61.29499817 11.72200012 Tm [(3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 66.57299805 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 71.07299805 11.72200012 Tm [(op)1(e)-1(n)] TJ ET EMC /P <> BDC BT 1 0 0 -1 93.19499969 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 97.69499969 11.72200012 Tm [(reading)] TJ ET EMC /P <> BDC BT 1 0 0 -1 130.66700745 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 135.16700745 11.72200012 Tm [(fra)1(me)] TJ ET EMC /P <> BDC BT 1 0 0 -1 160.23800659 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 164.73800659 11.72200012 Tm [(38)] TJ ET EMC /P <> BDC BT 1 0 0 -1 175.29400635 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q 1 0 0 1 0 16.35000038 cm q /GS2 gs 1 g 0.375 0.75 m 107.22499847 0.75 l 107.22499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.22499847 -0.25 l 108.22499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Sw)1(iss)1(prot:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 46.64799881 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.97499847 0.75 m 422.42501831 0.75 l 422.42501831 16.35000038 l 107.97499847 16.35000038 l h f* Q q 1 0 0 1 107.59999847 0 cm -0.625 -0.25 m 315.82501221 -0.25 l 315.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Q5JPI3)] TJ ET EMC /P <> BDC BT 1 0 0 -1 29.6060009 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 32.70000076 cm q /GS2 gs 1 g 0.375 0.75 m 107.22499847 0.75 l 107.22499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.22499847 -0.25 l 108.22499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Gene)] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.19400024 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.69400024 11.72200012 Tm [(Acc)1(ess)1(io)-1(n:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 74.86499786 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.97499847 0.75 m 422.42501831 0.75 l 422.42501831 16.35000038 l 107.97499847 16.35000038 l h f* Q q 1 0 0 1 107.59999847 0 cm -0.625 -0.25 m 315.82501221 -0.25 l 315.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(BC0)-1(24)-1(18)-1(8)] TJ ET EMC /P <> BDC BT 1 0 0 -1 43.33399963 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 49.04999924 cm q /GS2 gs 1 g 0.375 0.75 m 107.22499847 0.75 l 107.22499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.22499847 -0.25 l 108.22499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Purity:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 29.68899918 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.97499847 0.75 m 422.42501831 0.75 l 422.42501831 16.35000038 l 107.97499847 16.35000038 l h f* Q q 1 0 0 1 107.59999847 0 cm -0.625 -0.25 m 315.82501221 -0.25 l 315.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(>85)-1(%)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 27.40399933 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 31.90399933 11.72200012 Tm [(as)] TJ ET EMC /P <> BDC BT 1 0 0 -1 41.04499817 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 45.54499817 11.72200012 Tm [(determine)-1(d)] TJ ET EMC /P <> BDC BT 1 0 0 -1 95.54199982 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 100.04199982 11.72200012 Tm [(by)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.55400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 115.05400085 11.72200012 Tm [(Coo)1(massie)] TJ ET EMC /P <> BDC BT 1 0 0 -1 161.75900269 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 166.25900269 11.72200012 Tm [(blue)] TJ ET EMC /P <> BDC BT 1 0 0 -1 185.05400085 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 189.55400085 11.72200012 Tm [(st)1(ain)-1(ed)] TJ ET EMC /P <> BDC BT 1 0 0 -1 220.852005 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 225.352005 11.72200012 Tm [(SDS-P)1(AGE)] TJ ET EMC /P <> BDC BT 1 0 0 -1 269.97000122 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 65.40000153 cm q /GS2 gs 1 g 0.375 0.75 m 107.22499847 0.75 l 107.22499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.22499847 -0.25 l 108.22499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Expres)1(sion)] TJ ET EMC /P <> BDC BT 1 0 0 -1 48.75299835 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 53.25299835 11.72200012 Tm [(system:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 87.68000031 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.97499847 0.75 m 422.42501831 0.75 l 422.42501831 16.35000038 l 107.97499847 16.35000038 l h f* Q q 1 0 0 1 107.59999847 0 cm -0.625 -0.25 m 315.82501221 -0.25 l 315.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Escheric)-1(h)1(i)-1(a)] TJ ET EMC /P <> BDC BT 1 0 0 -1 47.53099823 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 52.03099823 11.72200012 Tm [(coli)] TJ ET EMC /P <> BDC BT 1 0 0 -1 67.05599976 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 81.75 cm q /GS2 gs 1 g 0.375 0.75 m 107.22499847 0.75 l 107.22499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.22499847 -0.25 l 108.22499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Tags)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 23.82299995 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.97499847 0.75 m 422.42501831 0.75 l 422.42501831 16.35000038 l 107.97499847 16.35000038 l h f* Q q 1 0 0 1 107.59999847 0 cm -0.625 -0.25 m 315.82501221 -0.25 l 315.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Hi)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 13.52200031 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.02199936 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 32.10599899 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 36.60599899 11.72200012 Tm [(C-Terminu)-1(s)1(,)] TJ ET EMC /P <> BDC BT 1 0 0 -1 88.47499847 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 92.97499847 11.72200012 Tm [(GST)] TJ ET EMC /P <> BDC BT 1 0 0 -1 110.02100372 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 114.52100372 11.72200012 Tm [(ta)1(g)] TJ ET EMC /P <> BDC BT 1 0 0 -1 128.60499573 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.10499573 11.72200012 Tm [(N-Terminu)-1(s)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.10400391 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q 1 0 0 1 0 98.09999847 cm q /GS2 gs 1 g 0.375 0.75 m 107.22499847 0.75 l 107.22499847 16.35000038 l 0.375 16.35000038 l h f* Q q -0.625 -0.25 m 108.22499847 -0.25 l 108.22499847 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACF 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(Ba)1(ckgr)1(o)-1(und)1(:)] TJ ET EMC /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 57.29199982 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q q /GS2 gs 1 g 107.97499847 0.75 m 422.42501831 0.75 l 422.42501831 16.35000038 l 107.97499847 16.35000038 l h f* Q q 1 0 0 1 107.59999847 0 cm -0.625 -0.25 m 315.82501221 -0.25 l 315.82501221 17.35000038 l -0.625 17.35000038 l h W n q 1 0 0 1 3.75 0.75 cm /P <> BDC BT /FAAACI 9 Tf 1 0 0 -1 0 11.72200012 Tm /GS2 gs 0.13333334 g [(May)] TJ ET EMC /P <> BDC BT 1 0 0 -1 18.53199959 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 23.03199959 11.72200012 Tm [(be)] TJ ET EMC /P <> BDC BT 1 0 0 -1 33.88600159 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 38.38600159 11.72200012 Tm [(involved)] TJ ET EMC /P <> BDC BT 1 0 0 -1 74.75499725 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 79.25499725 11.72200012 Tm [(in)] TJ ET EMC /P <> BDC BT 1 0 0 -1 87.19599915 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 91.69599915 11.72200012 Tm [(ap)1(opt)1(osis)] TJ ET EMC /P <> BDC BT 1 0 0 -1 133.69000244 11.72200012 Tm [( )] TJ ET EMC /P <> BDC BT 1 0 0 -1 138.19000244 11.72200012 Tm [(regulat)1(i)-1(o)1(n)-1(.)] TJ ET EMC /P <> BDC BT 1 0 0 -1 184.58700562 11.72200012 Tm /GS1 gs 0 g [( )] TJ ET EMC Q Q Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0 0.75 m 0 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.59999847 0.75 m 107.59999847 16.35000038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.59999847 17.10000038 m 107.59999847 32.70000076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.59999847 33.45000076 m 107.59999847 49.05000305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.59999847 49.80000305 m 107.59999847 65.40000153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.59999847 66.15000153 m 107.59999847 81.75 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.59999847 82.5 m 107.59999847 98.09999847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 107.59999847 98.84999847 m 107.59999847 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 422.80001831 0.75 m 422.80001831 114.44999695 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 0.375 m 423.17501831 0.375 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 16.72500038 m 422.42501831 16.72500038 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 33.07500076 m 422.42501831 33.07500076 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 49.42500305 m 422.42501831 49.42500305 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 65.77500153 m 422.42501831 65.77500153 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 82.125 m 422.42501831 82.125 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d 0.375 98.47499847 m 422.42501831 98.47499847 l S Q q /GS1 gs 0.75686276 G 0.75 w [0.75 0.75] 0 d -0.375 114.82499695 m 423.17501831 114.82499695 l S Q Q q 1 0 0 1 0 508.60699463 cm /P <> BDC BT /FAAAAH 9 Tf 1 0 0 -1 0 12.04500008 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 536.54602051 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 564.48498535 cm /P <> BDC BT /FAAAAH 10.5 Tf 1 0 0 -1 0 12.55799961 Tm [( )] TJ ET EMC Q q 1 0 0 1 0 592.42401123 cm Q Q 1 0 0 -1 0 841.90002441 cm endstream endobj 6 0 obj <>stream ºÝºÝÈÈÔÚÏßÊÓÆµÃâ·Ñ <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Ö©Öë´Ê>| <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´> <Îı¾Á´>